This deposition contains the processed and analysis-ready datasets supporting the mouse tumor study, including mouse scRNA-seq CellRanger output matrices, per-sample Seurat RDS objects, integrated scRNA-seq objects in RDS and H5AD formats, sample metadata, IHC image-analysis inputs and outputs, and IMC image-analysis inputs and outputs with associated spatial-analysis results. The imaging datasets are organized by modality, tissue/group, sample, and region of interest, with derived tables, masks, annotations, and visualization outputs provided alongside the corresponding source files. This record also includes a human DCIS scRNA-seq reference dataset provided by Dr. Fariba Behbod at the University of Kansas Medical Center, available under GEO accession number GSE333697.