HENGRUI PHARMA - An announcement has just been published by the issuer in the Chinese section of this website, a corresponding version of which may or may not be published in this section

or completeness of this announcement, and expressly expressly disclaims any liability arising out of or in reliance upon the whole or any part of the contents of this announcement. assumes no responsibility for any losses caused by such content.

Jiangsu Hengrui Pharmaceuticals Co., Ltd. Jiangsu Hengrui Pharmaceutical Co., Ltd.

(a joint stock limited company incorporated in the People's Republic of China) (Stock code: 1276)

Overseas regulatory announcement

This announcement is made in accordance with Rule 13.10B of the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited.

In accordance with the relevant laws and regulations of the People's Republic of China, Jiangsu Hengrui Pharmaceutical Co., Ltd. (the "Company")

The Shanghai Stock Exchange website (www.sse.com.cn) published the following announcement. They are listed below for reference only.

By order of the board of directors Jiangsu Hengrui Pharmaceutical Co., Ltd. Chairman

Mr. Sun Piaoyang

Shanghai, China March 25, 2026

As at the date of this announcement, members of the Board of Directors include (i) Executive Directors Mr. Sun Piaoyang, Mr. Dai Hongbin, and Mr. Feng Jinu; Mr. Zhang Lianshan, Mr. Jiang Ningjun and Mr. Sun Jieping; (ii) Ms. Guo Congzhao, a non-executive director; and (iii)

Independent non-executive directors are Mr. Dong Jiahong, Mr. Zeng Qingsheng, Mr. Sun Jinyun and Mr. Zhou Ji'en.

Company code: 600276 Company abbreviation: Hengrui Pharmaceuticals

Jiangsu Hengrui Pharmaceutical Co., Ltd.

2025 Internal Control Evaluation Report

All shareholders of Jiangsu Hengrui Pharmaceutical Co., Ltd.:

In accordance with the provisions of the "Basic Standards for Enterprise Internal Control" and its supporting guidelines and other internal control regulatory requirements (hereinafter referred to as "Enterprise Internal Control") Internal control standard system), combined with the company's (hereinafter referred to as the company's) internal control system and evaluation methods, daily supervision and professional internal control On the basis of this supervision, we conducted an evaluation on the effectiveness of the company’s internal control on December 31, 2025 (the base date for the internal control evaluation report). Evaluation.

1. Important Statement

In accordance with the provisions of the enterprise's internal control normative system, establish, improve and effectively implement internal controls, evaluate their effectiveness, and truthfully disclose The internal control evaluation report is the responsibility of the company's board of directors. The Supervisory Board supervises the establishment and implementation of internal controls by the Board of Directors. Managers are responsible Organize and lead the daily operation of enterprise internal control. The company’s board of directors, board of supervisors and directors, supervisors and senior managers guarantee that the contents of this report does not contain any false records, misleading statements or major omissions, and is individually responsible for the authenticity, accuracy and completeness of the report content. and joint and several legal liability.

The goal of the company's internal control is to reasonably ensure the legal compliance of operation and management, asset safety, and the authenticity and completeness of financial reports and related information. Improve operating efficiency and effectiveness and promote the realization of development strategies. Due to the inherent limitations of internal control, it can only achieve the above goals Provide reasonable assurance. In addition, internal controls may become inappropriate due to changes in circumstances or the degree to which control policies and procedures are followed may be compromised. There is a certain risk in predicting the effectiveness of future internal controls based on the internal control evaluation results.

2. Conclusion of internal control evaluation

3. Whether the company has any major deficiencies in the internal control of financial reporting on the base date of the internal control evaluation report □Yes √No

4. Conclusion of the evaluation of internal control over financial reporting

√Valid □Invalid According to the identification of major deficiencies in the company's internal control over the financial report, on the base date of the internal control evaluation report, there were no There are major deficiencies in internal control. The board of directors believes that the company has maintained safety in all major aspects in accordance with the requirements of the corporate internal control standard system and relevant regulations. Maintained effective internal control over financial reporting.

3. Whether significant deficiencies in internal control over non-financial reporting have been discovered

□Yes √No According to the identification of major deficiencies in the company’s internal control over non-financial reporting, the company found no non-financial reporting defects on the base date of the internal control evaluation report. Major deficiencies in internal control over financial reporting.

4. Factors that affect the conclusion of the internal control effectiveness evaluation from the base date of the internal control evaluation report to the issuance date of the internal control evaluation report □Applicable √Not applicable

There was no impact on the conclusion of the internal control effectiveness evaluation between the base date of the internal control evaluation report and the issuance date of the internal control evaluation report. factors.

5. Whether the internal control audit opinion is consistent with the company’s evaluation conclusion on the effectiveness of internal control over financial reporting √Yes □No

6. Whether the disclosure of major deficiencies in non-financial reporting internal control in the internal control audit report is consistent with the disclosure in the company’s internal control evaluation report

√Yes □No 3. Internal control evaluation work

(1). Scope of internal control evaluation

The company determines the main units, businesses and matters as well as high-risk areas included in the evaluation scope in accordance with the risk-oriented principle.

1. The main units included in the evaluation scope include: the parent company (aggregated and consolidated settlement center) and 26 first-level subsidiaries.

2. Proportion of units included in the evaluation scope: Indicator proportion (%)

The ratio of the total assets of the units included in the evaluation scope to the total assets of the company's consolidated financial statements 100 The ratio of the total operating income of the units included in the evaluation scope to the total operating income of the company's consolidated financial statements 100

3. The main businesses and matters included in the evaluation scope include: Organizational structure, development strategy, human resources, social responsibility, corporate culture, financial activities, procurement business, asset management, sales industry

services, research and development, engineering projects, financial reporting, contract management, information systems, etc. 4. High-risk areas of focus include:

Sales risks, R&D risks, product quality risks, production management risks, financial reporting risks, human resources risks, safety risks, etc.

5. The units, businesses, matters and high-risk areas included in the evaluation scope mentioned above cover the main aspects of the company’s operation and management. Are there any in major omissions □Yes √No

6. Whether statutory exemptions exist

□Yes √No 7. Other instructions

None

(2). Basis for internal control evaluation and identification standards for internal control deficiencies The company organizes and carries out internal control evaluation work based on the enterprise's internal control standard system and the company's various internal control systems and processes.

1. Whether the specific identification standards for internal control deficiencies have been adjusted from previous years □Yes √No

The company's board of directors determines major defects, important defects and general defects in accordance with the company's internal control standard system and in conjunction with the company's regulations. model, industry characteristics, risk preference, risk tolerance and other factors, distinguish between financial reporting internal control and non-financial reporting internal control, and study to confirm The specific identification standards for internal control deficiencies applicable to the Company have been determined and remain consistent with previous years.

2. Standards for identifying deficiencies in internal control over financial reporting The quantitative standards for the evaluation of internal control deficiencies over financial reporting determined by the company are as follows:

Indicator Name Quantitative Standard for Major Defects Quantitative Standard for Important Defects Quantitative Standard for General Defects Potential errors in operating income If the misstatement is ≥ the total operating income 0.5% of the total operating income ≤ If the misstatement is < the total operating income 1% misstatement <0.5% of total operating income 1% Potential misstatement of total profit Misstatement ≥ 5% of total profit 3% of total profit ≤ misstatement < Misstatement < 3% of total profit

Report 5% of total profit Description: None The qualitative standards for the evaluation of internal control deficiencies over financial reporting determined by the company are as follows:

Nature of defects Qualitative standard Major defects (1) Ineffective control environment; (2) The company’s directors, supervisors and senior managers commit fraud and cause significant losses and adverse effects to the company; (3) The certified public accountant discovers that there is a material misstatement in the financial report for the current period, and the internal control fails to function properly during operation. The misstatement can be discovered;

(4) Important deficiencies that have been discovered and reported to management are not corrected within a reasonable time; (5) The audit committee and internal audit department are ineffective in supervising the company’s internal controls. Important defects (1) Failure to select and apply accounting policies in accordance with generally accepted accounting principles; (2) Failure to establish anti-fraud procedures and control measures; (3) Single or multiple deficiencies occur in the financial reporting process. Although the standards for identifying major deficiencies are not met, the

Influence financial reporting to achieve true and accurate goals. General defects General defects refer to other control defects other than the above-mentioned major defects and important defects. Description: None

3. Standards for identifying deficiencies in internal control over non-financial reporting

The quantitative standards for the evaluation of non-financial reporting internal control deficiencies determined by the company are as follows: Indicator name Quantitative standard for important defects Quantitative standard for general defects 0.5% of net assets ≤ direct property loss < Direct property loss Direct property loss <0.5% of net assets 1% of net assets

Description: None The qualitative standards for the evaluation of non-financial reporting internal control deficiencies determined by the company are as follows: Nature of defects Qualitative standard

Major defects: If the probability of occurrence of the defect is high, it will seriously reduce the work efficiency or effect, or seriously increase the uncertainty of the effect. Qualitative or serious deviation from expected goals is a major flaw.

Important defects: If the possibility of a defect occurring is high, it will significantly reduce work efficiency or effectiveness, or significantly increase the effect of the defect. Certainty or significant deviation from expected goals are important flaws. General defects: If the possibility of a defect occurring is small, it will reduce work efficiency or effect, or increase the uncertainty of the effect. Or causing it to deviate from the expected goal is a general defect.

Description: None

(3). Identification and rectification of internal control deficiencies

1. Identification and rectification of internal control deficiencies over financial reporting

1.1. Major defects Whether the company has any major deficiencies in internal control over financial reporting during the reporting period

□Yes √No 1.2. Important defects

Whether the company has any important deficiencies in internal control over financial reporting during the reporting period □Yes √No

1.3. General defects

None 1.4. After the above rectifications, as of the base date of the internal control evaluation report, does the company have any significant internal control issues over financial reporting that have not been rectified? Defects

□Yes √No

1.5. After the above rectifications, as of the base date of the internal control evaluation report, does the company have any important internal control issues over financial reporting that have not been rectified? Defects

□Yes √No 2. Identification and rectification of internal control deficiencies in non-financial reporting

2.1. Major defects

Whether the company discovered any major deficiencies in non-financial reporting internal control during the reporting period □Yes √No 2.2. Important flaws

Whether the company discovered any important deficiencies in non-financial reporting internal control during the reporting period □Yes √No

2.3. General defects

None 2.4. After the above rectifications, on the base date of the internal control evaluation report, has the company discovered any major non-financial reporting internal control issues that have not been rectified? big flaw

□Yes √No

2.5. After the above rectification, on the base date of the internal control evaluation report, has the company discovered any major non-financial reporting internal control issues that have not been rectified? want defects

□Yes √No

4. Description of other major matters related to internal control

5. Rectification of internal control deficiencies in the previous year

□Applicable √Not applicable 2. Internal control operation status this year and improvement directions for the next year

□Applicable √Not applicable

3. Description of other significant matters □Applicable √Not applicable

Chairman (authorized by the board of directors): Sun Piaoyang Jiangsu Hengrui Pharmaceutical Co., Ltd. March 25, 2026