NewLimit raises USD 435m Series C to advance aging reprogramming medicine toward human trials

South San Francisco-based NewLimit, a biotechnology company focused on longevity medicine, [has closed](https://blog.newlimit.com/p/newlimit-raises-435m-led-by-founders?hide_intro_popup=true) a USD 435 million Series C funding round as it prepares to bring its first aging reprogramming therapy into human clinical trials. Founders Fund led the round, joined by new investors Thrive Capital, Greenoaks, and Quiet Capital. Returning investors included Kleiner Perkins, Abstract, Nat Friedman and Daniel Gross, Valor Equity Partners, Eli Lilly Ventures, and Human Capital, among others. The company said it plans to use the capital to advance its lead program — a prototype medicine designed to reverse cell age in old human liver cells — into first-in-human trials, which the company indicated are expected to begin next year. According to [NewLimit's operating plan](https://www.newlimit.com/operating-plan), the lead program is based on lipid nanoparticle-delivered RNA medicines designed to transiently express combinations of transcription factors in aged liver cells. The initial focus is alcohol-related liver disease, a setting where aging hepatocytes lose regenerative capacity and become increasingly susceptible to injury. The company has reported identifying multiple reprogramming payloads that restore youthful function in preclinical liver models with one of those selected for further development. NewLimit argues that its work represents one of the most advanced efforts in the emerging field of partial cellular reprogramming, which remains largely preclinical despite substantial investor interest. If the company proceeds on its stated timeline, it would represent one of the first direct tests of an epigenetic reprogramming approach in human subjects. The financing ranks among the largest private biotech rounds completed this year and underscores continued investor enthusiasm for longevity-focused drug development. The scale of the Series C reflects broader momentum in longevity-focused biotech, where investors have shown increasing appetite for programs targeting the biology of aging itself rather than individual age-related diseases. Eli Lilly Ventures' continued participation is notable, given Lilly's expanding interest in metabolic and age-related biology following the commercial success of its GLP-1 franchise. --- Spot something wrong? [Report an issue with this article](https://newsgen-prod.reframedata.com/feedback/newlimit-series-c-funding-raises-usd-435m-to)