Akari Therapeutics Completes Previously Announced PIPE, Strengthening Balance Sheet Ahead of Potential Key Clinical and Regulatory Milestones

TAMPA, Fla. and LONDON, June 29, 2026 — Akari Therapeutics, Plc (Nasdaq: AKTX), an oncology biotechnology company developing antibody drug conjugates (ADCs) with novel RNA splicing modulator payloads, today announced the completion of its previously announced PIPE through the consolidation of the remaining scheduled investment closings into a single funding event. Combined with warrant exercises completed in May, the Company received approximately $8.3 million in total capital during Q2 2026.

“We appreciate the decision of our investor group to complete the remaining funding earlier than originally scheduled, and for some of these investors to further increase their commitment through warrant exercises,” said Abizer Gaslightwala, President and Chief Executive Officer of Akari Therapeutics. “This additional capital is expected to provide added financial flexibility as we advance AKTX-101 towards a Phase 1 first-in-human clinical trial while advancing our proprietary PH1 RNA splicing modulator ADC payload through potential strategic partnerships.”

As previously announced, Akari entered into a securities purchase agreement with certain existing investors pursuant to which the Company agreed to sell and issue in a private placement an aggregate of 1,470,588 ADSs or prefunded warrants to purchase ADSs together with Series H warrants, Series I warrants and Series J warrants to each purchase 1,470,588 ADSs.

Under the purchase agreement, the $5.5 million gross proceeds of the offering were to be funded in three separate tranches, the first of which occurred at the end of May 2026, and the second and third closings of which were supposed to occur during June and July 2026, respectively. Subsequently, the parties agreed to consolidate the second and third closings into one final closing, which occurred on June 26, 2026. The issuance of the associated Series H, Series I and Series J warrants remains subject to shareholder approval at the Company's Annual General Meeting scheduled for June 30, 2026.

Separately, during May 2026 the Company received approximately $2.8 million in additional proceeds from the exercise of warrants by some of the investors who participated in the PIPE.

About Akari Therapeutics

Akari Therapeutics is an oncology biotechnology company developing next-generation antibody drug conjugates (ADCs) with a unique payload, PH1, which targets RNA splicing. Utilizing its innovative ADC discovery platform, the Company has the ability to generate ADC candidates and optimize them based on the desired application to any antigen target of interest. Akari’s lead candidate, AKTX-101, targets the Trop2 receptor on cancer cells with a proprietary linker, enabling it to deliver its novel PH1 payload directly into the tumor with minimal off-target effects. Unlike current ADCs that use microtubule inhibitors and DNA-damaging agents as their payloads, PH1 is a novel payload that is a spliceosome modulator designed to disrupt RNA splicing within cancer cells. This splicing modulation has been shown in preclinical animal models to induce cancer cell death while activating both the innate and adaptive immune systems to drive robust and durable activity. In preclinical studies, AKTX-101 has been shown to have significant activity and prolonged survival relative to ADCs with traditional payloads. Additionally, AKTX-101 has the potential to be synergistic with checkpoint inhibitors and has demonstrated prolonged survival as both a single agent and in combination with checkpoint inhibitors. The PH1 payload has also been demonstrated to be very active against cancer cells with key oncogenic drivers such as KRAS, BRAF, ARV7, FGFR3 fusions, and others. The Company has initiated IND enabling studies for AKTX-101 with a goal of starting its First-In-Human trial by mid-2027. Akari is also developing AKTX-102, an ADC candidate targeting CEACAM5 (Carcinoembryonic Antigen-related Cell Adhesion Molecule-5), a well-validated tumor antigen broadly expressed across multiple solid tumors. AKTX-102 is designed to leverage Akari’s proprietary PH1 spliceosome-modulating payload and a novel antibody construct to enable differentiated tumor cell killing and immune activation.

For more information about the Company, please visit www.akaritx.com and connect on X and LinkedIn.

Investor Relations Contact

JTC Team, LLC Jenene Thomas 908-824-0775 [email protected]