Nxera Pharma to Receive US$10 Million Milestone Payment from AbbVie under Collaboration Targeting Neurological Diseases

• This marks the fourth R&D milestone achieved under the collaboration, and the second in 2026, reflecting the steady progress of development under the collaboration
• Under the terms of the agreement, Nxera is eligible to receive up to US$1.2 billion in potential option, development and commercial milestones, in addition to tiered royalties based on sales

Tokyo, Japan and Cambridge and London, UK, 30 June 2026 – Nxera Pharma Co., Ltd. (“Nxera” or “the Company”; TSE 4565) announces that it has reached a fourth R&D milestone under its multi-target discovery collaboration with AbbVie focused on neurological diseases, resulting in a payment of US$10 million to Nxera.

Nxera and AbbVie entered this multi-target collaboration in 2022 to leverage Nxera’s NxWave™ platform to discover novel medicines targeting G protein-coupled receptors (GPCRs) associated with neurological disease. This current milestone relates to the identification of validated and differentiated ‘hit’ molecules against a neurology target.

Since the collaboration began, Nxera has hit all four expected near-term R&D milestones and received US$40 million in payments from AbbVie; the first milestone was achieved in June 2024, the second milestone in September 2025, and the third milestone in April 2026. Under the agreement with AbbVie, Nxera is eligible to receive further potential option, development and commercial milestones totalling up to US$1.2 billion, plus tiered royalties on global sales.

Christopher Cargill, President and CEO of Nxera Pharma, commented: “The achievement of this fourth milestone represents an important step forward, demonstrating that multiple programs under our drug discovery collaboration with AbbVie are steadily delivering results. We have now achieved two milestones in 2026, and we believe that progress across multiple targets under this collaboration further supports the productivity and future value of the partnership. We remain committed to expanding the value of our pipeline by creating novel therapeutic candidates that address significant unmet medical needs in neurological diseases.”

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About Nxera Pharma

Nxera Pharma is a technology powered biopharma company in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally. The Company has built an agile, new-generation commercial business in Japan to develop and commercialize innovative medicines, including several launched products, to address this high-value, large and growing market and those in the broader APAC region. In addition, the Company is advancing an extensive pipeline internally and in partnership with leading pharma and biotech companies, powered by its unique NxWave™ GPCR structure-based drug discovery platform. Nxera Pharma operates at key locations in Tokyo and Osaka (Japan), London and Cambridge (UK), Basel (Switzerland) and Seoul (South Korea) and is listed on the Tokyo Stock Exchange (ticker: 4565).

For more information, please visit www.nxera.life LinkedIn: @NxeraPharma | X: @NxeraPharma | YouTube: @NxeraPharma

Enquiries

Nxera – Media and Investor Relations

Shinya Tsuzuki, VP, Head of Investor Relations +81 (0)3 5210 3399 | +44 (0)1223 949390 |[email protected]

MEDiSTRAVA (for International Media)

Mark Swallow, Frazer Hall, Erica Hollingsworth +44 (0)203 928 6900 | [email protected]