Can-Fite Positive Phase 2a Pancreatic Cancer Study Data Accepted for Presentation at ESMO Congress 2026, One of the World's Premier Scientific Meetings in Oncology

Predominantly third-line pancreatic cancer patients demonstrated durable survival despite advanced disease; patient who received Namodenoson as second-line therapy remains alive more than 18 months

Ramat Gan, Israel, July 20, 2026 (GLOBE NEWSWIRE) -- Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF), a clinical-stage biotechnology company developing a pipeline of proprietary small molecule drugs targeting oncological and inflammatory diseases, today announced that an abstract highlighting positive results from its Phase 2a study of Namodenoson in patients with advanced pancreatic ductal adenocarcinoma (PDAC), has been accepted for poster presentation at the European Society for Medical Oncology (ESMO) Congress 2026.

The accepted abstract, entitled "Durable Disease Stabilization with Namodenoson in Advanced Pancreatic Adenocarcinoma: Results from a Phase 2a Study," will be presented as a poster during the ESMO Congress, one of the world's premier scientific meetings in oncology.

The Phase 2a study evaluated oral Namodenoson in patients with advanced pancreatic cancer who had progressed following prior standard therapies. As previously announced, the study successfully achieved its primary safety endpoint and demonstrated encouraging survival outcomes together with durable disease stabilization in this difficult-to-treat patient population.

"We are pleased that our abstract has been selected for presentation at ESMO, one of the most prestigious international oncology conferences," said Pnina Fishman, Ph.D., Chairperson and Chief Scientific Officer of Can-Fite BioPharma. "Acceptance by ESMO provides important scientific recognition of our pancreatic cancer program and offers an opportunity to present our clinical findings to the global oncology community. We believe these data further support the continued development of Namodenoson for patients with advanced pancreatic cancer."

Namodenoson is a highly selective A3 adenosine receptor agonist with a unique mechanism of action that induces apoptosis of cancer cells while exhibiting an excellent safety profile. The drug has demonstrated anti-tumor activity across multiple preclinical models, including pancreatic cancer, and is also being developed for hepatocellular carcinoma and MASH.

Can-Fite is currently planning the next stage of clinical development for Namodenoson in pancreatic cancer, with a Phase 2b study designed to evaluate Namodenoson in combination with chemotherapy based on encouraging clinical findings and supportive preclinical evidence demonstrating synergistic anti-tumor activity.

Additional details regarding the poster presentation, including presentation date, session information, and poster number, will be announced when they become available.

About Pancreatic Ductal Adenocarcinoma (PDAC)

Pancreatic ductal adenocarcinoma is among the most aggressive malignancies and remains a leading cause of cancer-related mortality worldwide. Patients with advanced disease who progress following standard therapies have limited treatment options and continue to face poor clinical outcomes, underscoring the need for novel therapeutic approaches.

About Namodenoson

Namodenoson is a small orally bioavailable drug that binds with high affinity and selectivity to the A3 adenosine receptor (A3AR). Namodenoson is currently being evaluated in a pivotal Phase 3 trial for advanced liver cancer, concluded successfully a Phase 2a study in pancreatic cancer and is enrolling patients in a Phase 2b trial for the treatment of Metabolic Dysfunction-associated Steatohepatitis (MASH). A3AR is highly expressed in diseased cells whereas low expression is found in normal cells. This differential expression may be one of the important factors that accounts for the excellent safety profile of the drug.

About Can-Fite BioPharma Ltd.

Can-Fite BioPharma Ltd. (NYSE American: CANF) (TASE: CANF) is an advanced clinical stage drug development Company with a platform technology that is designed to address multi-billion dollar markets in the treatment of cancer, liver, and inflammatory disease. The Company’s lead drug candidate, Piclidenoson recently reported topline results in a Phase 3 trial for psoriasis and commenced a pivotal Phase 3 trial. Can-Fite’s liver drug, Namodenoson, is being evaluated in a Phase III trial for hepatocellular carcinoma (HCC), a Phase 2b trial for the treatment of MASH, and in a Phase 2a study in pancreatic cancer. Namodenoson has been granted Orphan Drug Designation in the U.S. and Europe and Fast Track Designation as a second line treatment for HCC by the U.S. Food and Drug Administration. Namodenoson has also shown proof of concept to potentially treat other cancers including colon, prostate, and melanoma. CF602, the Company’s third drug candidate, has shown efficacy in the treatment of erectile dysfunction. These drugs have an excellent safety profile with experience in over 1,600 patients in clinical studies to date. For more information please visit: www.canfite.com.

Contact

Can-Fite BioPharma Motti Farbstein [email protected] +972-3-9241114