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Puris: 2025 Environmental, Social and Corporate Governance Report

Shenzhen Stock Exchange

2026/04/29

Paper verification: Stock abbreviation: Puris Stock code: 301257 This report uses environmentally paper

ENVIRONMENTAL, SOCIAL AND GOVERNANCE REPORT PRUIS (SHANGHAI) MEDICAL TECHNOLOGY DEVELOPMENT CO., LTD.

Investor hotline: 021-60755800

Email: [email protected]

Company address: 23rd Floor, World Trade Building, No. 500 Guangdong Road, Huangpu District, Shanghai

CONTENTS Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd.

2025 Environmental, Social and Corporate Governance Report

01 02

ESG Management Standardized Governance

Pay attention to operational risks and opportunities and lay a solid foundation for sound operations

Green environmental protection

Indicator Index 94

Helping the country’s low-carbon development

Reader Feedback 101 Addressing Climate Change 80

Environmental Compliance Management 84

Efficient use of energy 86

Pu Ruisisi ((Shanghai)) Medical and Pharmaceutical Science and Technology Development Co., Ltd.

22002255 Annual Environmental, Social and Corporate Governance Report

About this report

This report is prepared and released by Puruis (Shanghai) Pharmaceutical Technology Development Co., Ltd. (hereinafter referred to as "Purisi" or "the company" or "we")

Data description

’s third annual Environmental, Social and Corporate Governance (ESG) Report, which analyzes Puruis’ practice and development in environmental, social and corporate governance in 2025

Systematically summarize and disclose the company's situation in order to respond to the concerns of shareholders, investors and other stakeholders about the company's efforts in sustainable development. All data disclosed in this report come from the company's public documents, internal documents and relevant statistical data. Unless otherwise stated, all weights and measures are in the metric system, and currencies are in the metric system.

All prices are in RMB.

Compilation basis

Report review

This report refers to the Global Sustainability Standards Board (GSSB) Sustainability Reporting Standards (GRI Standards 2021), Shenzhen Securities Exchange

Self-regulatory Guidelines for Listed Companies No. 17 - Sustainability Report (Trial)" and "Self-regulatory Guidelines for Companies Listed on the GEM of Shenzhen Stock Exchange No. 17". This report was reviewed and approved by the second meeting of the company's fourth board of directors on April 27, 2026 after being confirmed by the Company's Strategy and Sustainable Development Committee. No. 3 - Preparation of Sustainability Report (Revised in 2026)".

On the basis of complying with China’s current regulatory requirements, this report also refers to the industry-based disclosure framework issued by the International Sustainability Standards Board (ISSB), combined with the public

Report released

According to the nature of the company's business, select and compare the SASB "Professional & Commercial Services (SV PS)" line applicable to the professional and business service industry.

Carry out relevant information disclosure according to industry standards. The company focuses on issues of substantial importance to the industry, such as data security, professional ethics, and human capital management, and manages relevant issues. This report is released in electronic form. Readers can download and review it from clinplus.com (http://www.cninfo.com.cn) or the company's official website (http://www.smo-mechanisms and key performance indicators, and present them accordingly in the report. Relevant disclosures are based on the systems, processes and performance that the company has established and actually operates.

Based on performance, no additional commitments beyond existing management arrangements were made. The content disclosed in this report aims to improve the comparability and transparency of information for investors and

If readers have questions or suggestions about the content of this report, or want to know other relevant information, please contact us through the following methods: Reference to other stakeholders.

Investor hotline: 021-60755800

Email: [email protected]

Report scope

Company Address: 23rd Floor, World Trade Building, No. 500 Guangdong Road, Huangpu District, Shanghai Time Scope: This report is an annual report, covering the period from January 1, 2025 to December 31, 2025 (hereinafter referred to as the "Reporting Period"), and part of the content is published

Factors that consider business/project continuity or significant impact will be traced forward or extended backward. The organizational scope covered by the report is combined with the company’s annual financial report.

The table scope remains consistent.

02 03

Manager's speech

Dong: With digital intelligence as its wings, the value of technology lies in responding to real needs, solving industry pain points, and reshaping service value. Purisi takes scientific and technological innovation as its priority

Empower the new paradigm of clinical research as the core engine, promote the deep integration of artificial intelligence and clinical research, and continue to explore the use of digital intelligence methods in the entire clinical trial process

application potential in the process. The company's independently developed "Ruixing Clinical Trial Text Generation Algorithm" has been registered with the Cyberspace Administration of China, promoting the key leap from "manual dependence" to "system empowerment" in clinical research, and accurately solving industry pain points such as cumbersome, time-consuming and error-prone information processing in clinical research. At the same time, we ensure that the entire data flow process is traceable, safe and compliant, and systematically optimize the collaborative efficiency of all aspects of clinical trials. Within the framework of compliance and ethics, we insist on improving clinical trials with technology and responding to pharmaceutical research needs with innovation.

Talent-oriented The development of the industry cannot be separated from the support of talents, let alone the guidance of responsibility. Puruis always adheres to the core principle of "people-oriented" to build a responsible ecology, provides diversified welfare care for employees, is committed to creating an equal, inclusive, open and dynamic working environment for employees, and attaches great importance to talent cultivation and empowers employee growth. Relying on the "Purisi Growth Center" digital platform, we provide employees and partners with efficient and convenient professional training support, actively participate in the in-depth integration of industry, academia and research, industry self-discipline construction and professional value sharing, and continue to promote the standardization and capability improvement of the clinical research service industry.

2025 will be a year in which Puruis will pioneer in changes and make breakthroughs in deep cultivation. Facing the complex and ever-changing external environment, we always insist on

Practice green

We attach great importance to the coordinated development of corporate operations and the ecological environment, and firmly follow the path of green and low-carbon development. In 2025, the company

Integrate the concept of sustainable development into every aspect of corporate operations, lead the direction with responsibility, and fulfill the mission with actions. We uphold the principle of "innovation

Building a low-carbon future together

Officially joined the Science-Based Target Initiative (SBTi), actively participated in the CDP climate change questionnaire disclosure, and obtained a B-level (management

With the corporate vision of "solving clinical trials in China and helping new drugs benefit patients faster", we continue to promote the digital and intelligent reconstruction of business processes and deepen

management level) rating, marking our progress in climate governance and information disclosure. Our continuous system

ESG governance and practice strive to explore a more resilient and responsible development path between promoting the industry forward and fulfilling social responsibilities.

Carry out green office practices, promote the implementation of green concepts in daily operations, continue to reduce the impact of operational activities on the environment, and jointly protect our planet.

With professionalism, we know that clinical trials are not only a process of scientific exploration, but also a solemn commitment to patients’ lives. As a large

A data-driven clinical research service provider that protects life, Purixisi has always provided professional, efficient and reliable solutions to shorten the time for innovative drugs.

distance from the patient. In 2025, we will continue to help a number of representative innovative drugs at home and abroad be approved for marketing.

We will fulfill our core mission of “helping new drugs benefit patients faster” with solid project results and build a moat of brand trust.

Behind every achievement is the persistence of all employees in "awe, honor and responsibility". In 2025, Puruis's ESG practices once again received continued attention and high recognition from the outside world. Wind ESG was rated A-level and was selected into the "Excellent Practice Cases of Sustainable Development of Listed Companies" by the China Listed Companies Association and the "Top 100 ESG Companies" list selected by the Board of Directors and Secretaries of Listed Companies. These honors are an affirmation of past efforts. In terms of social responsibility, Puruis is based on the biomedical industry and continues to pay attention to medical accessibility, educational welfare and rural revitalization.

It further motivates us to promote sustainable development with higher standards.

promote the in-depth integration of public welfare projects and corporate professional capabilities. Relying on "Ruizhijia" patient health science popularization

Platform, we carry out in-depth patient education and public health communication, break information barriers and stereotypes, and help build a better future. In the future, Puruis will continue to focus on the high-quality development of the biomedical industry, drive service upgrades with technological innovation, and help accelerate research and development with professional capabilities, looking forward to an inclusive and equitable medical and health ecosystem. Together with our partners, we will continue to implement the ESG development concept with a more open mind and more pragmatic actions, and become a solid bridge that benefits patients around the world.

Mr. Lai

spring

reason

treasure

Purex (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Purex ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

Yang

Macro

great

04 05 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Numbers say 2025

Overview Take innovation as your sail and make steady progress.

In a complex and ever-changing industry environment, Puruis has always taken innovation as the beacon and professionalism as the cornerstone, and maintained strategic focus in the market wave where challenges and opportunities coexist.

Puris·Impression

During the reporting period, the company focused on three major directions: digital intelligence upgrade, quality control and professional talent development, and steadily promoted various business operations. While consolidating clinical research service capabilities, the company continued to improve the company's sustainable development resilience.

Steady growth

Company Profile During the reporting period, Puruis maintained a steady operating momentum and demonstrated strong operating resilience and repair capabilities in a complex industry environment.

2025

year

8.43 4.82%

Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. (301257.SZ) is a large-scale company that achieved operating income of 100 million yuan, a year-on-year increase;

1.10 3.01%

A data-driven clinical research service provider, since its establishment in 2013, it has always focused on making net profits of 100 million yuan at home and abroad, a year-on-year increase;

11.32 13.20%

Clinical research and development of pharmaceutical companies, medical device companies and some health-related products provide efficient and

The value of newly signed contracts excluding tax is 100 million yuan, a year-on-year increase.

Compliant outsourcing services. Puruis adheres to the "patient-centered" concept and through professional projects

The company attaches great importance to shareholder returns and has insisted on implementing a positive and stable cash dividend policy since its listing, sharing the company's development results with shareholders, and helping sponsors to efficiently and quickly promote clinical trials through robust project management capabilities and high-standard quality management systems.

Maintain a healthy capital structure through financial management, focus on business expansion, and lay a solid foundation for sustainable development.

The implementation and execution of trials will allow innovative drugs and treatments to benefit patients faster and better. The company always attaches great importance to

Accelerating digitalization and intelligent upgrades, the independently developed "Ruixing Clinical Trial Text Generation Algorithm"

Innovation Empowerment

It has passed national registration and continues to use technological innovation to improve the efficiency and quality of clinical trials, empowering

Puruis always regards innovation as a key factor to drive forward, continues to promote the upgrade of service models and management methods, and is committed to building the leading big data-driven clinical research in China.

An innovative clinical research service provider.

With the digital intelligence platform as its core support, the company provides industry customers with comprehensive solutions such as FSP services, verification assistance, SSU services, third-party quality control and audits, clinical trial execution, CRO services, strategic modeling and patient recruitment.

The company's Ruixing intelligent management system built on the "Ruixing clinical trial text generation algorithm" integrates core functions such as question and answer robots, patient recruitment, privacy desensitization, assisted generation of medical documents, clinical trial quality control, e-TMF automatic classification and quality inspection, and can efficiently generate clinical trial-related texts based on user input. This technological breakthrough accurately solves industry pain points such as cumbersome, time-consuming and error-prone information processing in clinical research, and promotes high-quality and efficient clinical trial projects from the core links. At the same time, it is in line with the "Pharmaceutical Industry Digital Transformation Implementation Plan (2025-2030)" to establish intelligent clinical research collaboration, meet the requirements of data collection and quality traceability throughout the pharmaceutical R&D and production process, accelerate project advancement and the implementation of new drugs, and build core competitiveness for customers.

At the same time, the company's independently developed "an adverse event grade determination method, electronic equipment and storage media" and "database-based multi-center collaborative execution project quality monitoring system" were authorized by the national invention patent, further solidifying the technical foundation in the field of clinical trial quality management and execution.

06 07Purimis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

The company continues to optimize the structure and efficiency of its business service network and implement lean execution

Relying on its deep accumulation and rich project experience in multiple disease fields, Purixisi continues to provide high-quality execution support for the research and development of innovative drugs.

During the reporting period, the company assisted in the successful launch of a number of landmark innovative drugs, including:

The world's first new PD-1/VEGF bispecific antibody drug The world's first approved EGFR/c-MET biantibody

Headquarters Shanghai

3 4

The world's first and currently only ABL myristoyl pocket

China's first approved hemophilia AAV gene therapy drug (STAMP) is a targeted drug with an innovative mechanism

5 6

4,400+ 2,650 4,372 4,200 China’s first and currently only interleukin 23 inhibitor approved for the treatment of adult obesity with moderate to severe obstructive sleep apnea in obese patients with active Crohn’s disease.

(OSA) Prescription Drugs

The company has participated in cumulative clinical trial projects. Number of projects in progress. Number of employees. Among them, business personnel exceed

960 1,300 200

Home Home Cities 7 8

By the end of 2025, we have served a total of clinical trial institutions. The number of clinical trial institutions that can be covered. The service scope covers the whole country.

China's first and currently only approved domestically produced IL-12/China's first and currently only approved IL-23 "dual-targeting" monoclonal antibody drug targeting PSMA, radioligand therapy drug

Leading professional practice

9 10

Puris actively participates in the construction of industry rules and standards. The company's senior managers have participated in drafting and formulating multiple industry consensuses based on years of clinical research management practice.

China's first approved CKD-aP and group standards for the treatment of adult hemodialysis patients, including norms and consensus documents related to CRC management and competency assessment in multiple places, contribute practical experience to promote the standardization and professional development of clinical research. China’s first approved EGFR-targeting antibody conjugate

A highly selective peripheral kappa opioid receptor agonist

At the same time, the company continues to create a professional learning atmosphere and provides systematic and digital training support to employees and partners through the "Purisi Growth Center":

24,000 113 279

remaining hours hours

Internal training system video Average training time per employee Training time for new employees

Thank you letter 60 25,000

60,000

Closing + remaining sessions Person-time The company has received a total of more than 60,000 letters of thanks in the past five years, covering sponsors, patients, researchers and research institutions

and other multiple entities, reflecting the market and industry’s continued recognition of the company’s service quality.

Professional training for clinical trial institutions External training coverage

08 09Purimis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Excellent service

Brand Culture

The company continues to deepen patient service practices and is committed to improving the accessibility of medical information and public health awareness.

During the reporting period, the patient service brand “Rui’s Home” further enriched the form and content of disease science popularization and popularized clinical trial-related knowledge to the public.

and health management concept:

Our vision & mission

208 648

Innovative clinical trial solutions to help new drugs benefit patients faster

Publish popular science videos Publish popular science tweets

our values

At the same time, the company optimized the functions of the "Purisi Clinical Trial Recruitment Information" applet, integrating the medical treatment process, registration, transportation and information of more than 600 hospitals across the country.

Use professionalism to win respect for hospitalization information, and set up special disease knowledge and care columns to provide patients with more convenient and transparent medical support.

Do not do any work that violates GCP and compliance requirements, do not falsify data, do not do any medical judgment work, do not accommodate any bad habits in clinical trials, and truly improve the quality of clinical trials in China

Promote culture · Keep responsibility in mind

Purisi adheres to the core values of "earning respect through professionalism" and upholds our spirit of awe, responsibility and honor.

The "Three Hearts" spirit continues to shape an agile, innovative, cooperative and customer-oriented organizational culture.

The three core values - awe, responsibility and honor. During the reporting period, the company's ESG management practices reached a new level. The company has disclosed ESG reports for two consecutive years.

It demonstrates our continuous investment and governance transparency in the field of sustainable development. Company Wind ESG Review

It has been stably maintained at the A-level level and won many awards such as “Excellent Practice Cases of Sustainable Development of Listed Companies”.

This recognition fully reflects the positive attitude of the market and professional institutions towards the effectiveness and long-term value of the company’s ESG work.

Our Code of Conduct

Definitely.

Agile, innovative, collaborative, customer-oriented

10 11

moment of honor

2025 Shanghai Specialty, Specialty, New and New Quality Productivity Industry Practice Demonstration Cases A-level (Excellent) Evaluation of Shenzhen Stock Exchange’s Information Disclosure 2024 Golden Bull Award·Golden Letter Award (First Batch) Small and Medium Enterprises

2025 Shanghai's Most Growth Specialized and New Enterprise 2025 Major Achievements Honor Award Huangpu District Private Economy Science and Technology Innovation Pioneer 2025 Listed Company Board of Directors 2025 Listed Company Board of Directors 2025 Listed Company Board of Directors Office Brand Value 50+ Secretary Duty Performance Evaluation 5A Rating Excellent Practice Cases Best Practice Cases Huangpu District "Pujiang Harmony" Commercial Mediation Alliance 2025 Sustainable Development of Listed Companies Outstanding Small and Medium Investor Concerns Award Ideal and Belief Education Guidance Points for Private Economists

Excellent practice cases

12 13

moment of honor

2025 China Clinical CRO Ranking "Industry-Leading CRO Company" Award China Pharmaceutical Quality Management Association 2025 Excellent Partner Excellent Cooperation Unit Award Excellent Partner TOP20 - Deputy Chairman Unit

Best Partner in 2025 Best Cooperation SMO in 2025 Excellent Partner Award Excellent SMO Company 2025 Innovation Ecosystem Achievement List

Selected Grade A SMO Outstanding SMO Company in 2025 "ESG Market Model Enterprise" "ESG New Benchmark Enterprise Award" The 2nd Board Secretary's Top 100 ESG Companies 14 15

ESG management

Pay attention to operational risks and opportunities

Sustainable Development Strategy 18

Sustainable development structure and management mechanism 18

Stakeholder Management 20

Identification and assessment of important issues 22

ESG Internal Advocacy 23

16 17 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

ESG governance structure

sustainable development strategy

Puruis has systematically integrated the concept of sustainable development into the overall development strategy and daily operation management, and closely focused on the compliance requirements of the pharmaceutical clinical trial service industry. Puruis has built a three-level ESG governance structure composed of decision-making, management and executive levels, forming a closed-loop industry responsibility and long-term value creation goal of "decision-making leadership, overall management, and coordinated execution" to systematically promote environmental, social and corporate governance (ESG) work. We are committed to actively spreading the management system throughout the industry ecosystem.

Bohe practices the concept of social responsibility and joins hands with upstream and downstream partners in the industry chain to jointly promote the coordinated development and sustainable progress of enterprises, industries and society.

decision-making level

At the governance level, the company adheres to compliance operations, business ethics and risk prevention and control as its core cornerstones to build a solid institutional guarantee for sustainable development. At the social level, the company’s board of directors, as the company’s highest decision-making body for sustainable development, is responsible for ESG-related strategies, major matters and the annual PuriSi Board of Directors.

The company focuses on the quality of clinical trials, protection of subjects' rights and interests, and information security and privacy protection, continues to improve the service value to patients, sponsors, and medical institutions, and assumes ultimate responsibility for the same goal.

We always attach great importance to employee career development, professional capacity building and working environment protection. At the operational level, the company continues to improve its internal control system, strengthen information security and privacy

Private management, proactively identify and effectively respond to compliance and operational risks. The above key areas together constitute the company's core framework for identifying and managing ESG-related risks and opportunities. The Strategy and Sustainability Committee is established at the board of directors level as a specialized research and supervision organization responsible for strategic and sustainable development.

Provide strong support for continuous optimization of governance and operational decisions. review, evaluate and guide the company’s long-term development strategy and important matters in the field of sustainable development, and regularly report to the Development Committee

The board of directors reports on the progress of ESG-related work.

In order to strengthen the sustainable development governance mechanism, the company's board of directors has established a strategy and sustainable development committee, which is responsible for the company's medium and long-term development strategies and major investment decisions.

Management

Conduct research and make suggestions on matters related to sustainable development, promote the synergy between ESG goals and the company's overall strategy, and help the company build on a solid foundation of compliance

achieve high-quality development and actively contribute to China’s construction of a biomedical power.

At the management level, the company has established an ESG Management Committee. Under the leadership of the Board of Directors and the Strategy and Sustainable Development Committee, it serves as the overall coordination and management center for the company's ESG work, and is responsible for researching and continuously tracking ESG. The ESG Management Committee

ESG

Policies, regulations and regulatory requirements, formulate strategies, goals, plans and institutional arrangements related to the company's ESG governance, Table: Correspondence between the company's ESG strategy and key operational risks Coordinate and promote the implementation of ESG work, and supervise and evaluate the implementation of various ESG management initiatives.

Main risk types Industry background Company response direction

Execution layer

At the executive level, the ESG working group serves as the specific execution and coordination body, responsible for transforming the company's sustainable development compliance risks and management requirements into operational tasks, coordinating various functional departments to promote ESG-related work, and coordinating the ESG working group

Summary, feedback and continuous improvement of implementation progress.

Data and privacy risks Increased informatization Information security and privacy governance system

Each functional department responsible for relevant issues implements environmental management, employee development, business ethics, and responsible for relevant issues according to the division of responsibilities.

Information security, privacy protection, supply chain responsibility and other specific work, embedding ESG requirements into daily business processes and functional departments

Reputational risk High social attention in the industry Business ethics and reporting mechanism

in management practice.

Talent and execution risk CRC professional requirements improvement training and capacity building system

Puris won the

"Excellent Practice Cases of Sustainable Development of Listed Companies in 2025"

Sustainable development structure and management mechanism

In November 2025, the "2025 Listed Companies Sustainable Development Conference" hosted by the China Listed Companies Association

The company has established a sustainable development governance structure covering the board of directors, management and functional departments, and systematically integrated ESG concepts into the company's strategic decision-making and daily operations. The meeting was held in Beijing. At the meeting, the China Listed Companies Association released the 2025 Excellent Sustainable Development Guidelines for Listed Companies.

Management, clarify the division of responsibilities through institutional arrangements, and form a top-down management mechanism with clear rights and responsibilities and coordinated advancement. Through goal setting, process tracking, and practical case selection results, the company relies on its experience in corporate governance, employee development, and giving back to society.

Promote the continuous implementation of sustainable development-related requirements in operation and management through internal review and management feedback. Excellent practice, won the "Excellent Practice Case of Sustainable Development of Listed Companies in 2025".

18 19 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

In terms of institutional guarantees, the company continues to optimize the corporate governance structure in accordance with the provisions of the Company Law, the Guidelines on the Articles of Association of Listed Companies and other relevant laws and regulations.

Puruis’ main stakeholders and communication situation in 2025

The Audit Committee of the Board of Directors has assumed the relevant supervisory powers of the Board of Supervisors, further strengthened its supervisory functions over financial management, internal control, compliance operations and risk management, and promoted

The dynamic supervision mechanism has transformed from formal compliance to substantive effectiveness.

Government and Regulatory Agencies Shareholders and Investors

At the same time, the company has established and continuously improved the internal control and compliance audit mechanism, regularly conducted internal control effectiveness and compliance reviews, and integrated anti-corruption, anti-bribery,

Key matters such as information security and data compliance are included in the scope of daily supervision and special inspections. Relevant review results are communicated to management, the audit committee and

National ministries, local governments, securities regulatory agencies, shareholders, potential investors

The board of directors' report provides a solid institutional guarantee for the company's stable operations and sustainable development. Market regulatory agencies, tax agencies, etc. Securities analysts, rating agencies

Main issues of concern Main communication methods/channels Main issues of concern Main communication methods/channels

█ Compliance operations █ Daily policy implementation and compliance reporting █ Operating performance and investment returns █ Shareholders’ meeting

█ Economic benefits and industry contribution █ Institutional inspection and research █ Corporate governance █ Regular/temporary information disclosure

Stakeholder Management

█ Business Ethics, Integrity and Compliance █ Official Documents █ Information Transparency █ Investor Meetings and Roadshows

█ Email and telephone communication █ ESG performance █ Investor hotline and dedicated email The company always attaches great importance to communication and cooperation with various stakeholders, adheres to the principles of legal compliance, fairness and transparency, integrity and responsibility, and continues to improve the management mechanism of the stakeholder █ Shenzhen Stock Exchange "Interactive Easy" platform.

Based on its business characteristics, the company systematically pays attention to and actively responds to the reasonable concerns of all parties, including shareholders and investors, employees, customers, medical institutions and researchers, and suppliers.

Core stakeholders such as suppliers, partners, and regulatory agencies. Customers Employees

Pharmaceutical companies, biotechnology companies, all employees of the company

In terms of investors and shareholders, the company fulfills its information disclosure obligations in accordance with laws and regulations, and effectively protects the rights and interests of investors through standardized corporate governance and transparent communication mechanisms.

Medical device companies, clinical research institutions

The right to know and the right to participate; in terms of employees, the company strengthens employees’ compliance awareness and professional ethics through system promotion, training and internal communication mechanisms;

In terms of customers and partners, the company adheres to the principles of fair competition and honest cooperation, strictly implements anti-bribery, anti-unfair competition and anti-money laundering related systems, and promotes the establishment of a healthy and sustainable cooperation ecosystem. █ Service quality and project delivery █ Customer communication meetings █ Employee rights and benefits █ Internal system release █ Compliance and ethics █ Customer satisfaction survey █ Occupational health and safety █ Employee training and growth center █ Data security and privacy protection █ Daily project communication (email/telephone) █ Talent training and career development █ Employee Satisfaction Survey The company has established a multi-channel complaint and feedback mechanism to encourage employees and external stakeholders to supervise matters such as business ethics, compliance operations, and information security.

█ Intellectual property protection █ Customer visits and service feedback mechanism █ Organizational culture and cohesion █ Suggestion box and internal communication platform and feedback, and protect the legitimate rights and interests of whistleblowers in accordance with the law, and continue to improve the transparency and responsibility level of corporate governance. Relevant reports and feedback are managed by the Compliance and Internal Audit Department █ Customer Relationship Management █ Internal Publications

Acceptance, investigation and tracking, and serve as an important reference for continuous improvement of internal management. █ Communication meetings at all levels

Partners Community & Public

Industry associations, hospitals, suppliers and communities where the company operates its business

Service Partners Patients and the Public

Main issues of concern Main communication methods/channels Main issues of concern Main communication methods/channels

█ Compliance management █ Business communication and agreement signing █ Accessibility of medical information █ Health science popularization platform "Rui's Home" █ Clinical trial ethics █ Project collaboration and communication █ Health science popularization and patient support █ Online consultation and public welfare Q&A █ Industry standards and collaborative development █ Satisfaction survey █ Social welfare █ Volunteer and public welfare activities █ Responsible supply chain █ Industry conferences, forums and seminars █ Resource conservation and environmental responsibility

20 21

Identification and assessment of material issues ESG internal advocacy

Assessment of material issues is an important part of a company's ESG management, helping the company to comprehensively identify risks and opportunities, and sort out ESG strategic planning and work priorities. The company regards ESG concepts and compliance culture as an important part of corporate culture construction, and continues to strengthen the depth of understanding and execution of sustainable development among all employees through system construction, training and promotion, and implementation of responsibilities.

Sustainability Report (Trial)" and other requirements, and refer to the "Self-discipline Supervision Guidelines for Companies Listed on the Growth Enterprise Market of Shenzhen Stock Exchange No. 3 - Sustainability Report

Report Preparation (Revised in 2026)", which identifies and analyzes important issues from the dual dimensions of "impact importance" and "financial importance". At the institutional level, the company has established an anti-bribery, anti-corruption and business ethics management system covering directors, senior managers and all employees, and has a clear zero-tolerance stance.

And embed system-related requirements into business processes and internal control systems to ensure the effective implementation of the system. During the reporting period, in the absence of major changes in the business model and policy environment, the company conducted a review of the issue library and evaluation based on the dual importance assessment in 2024.

The assessment results and priorities were reviewed, and necessary updates were made based on external policy supervision and business changes. In terms of capacity building, the company regularly organizes directors, senior managers and employees to conduct special training on business ethics, anti-bribery, pharmaceutical industry compliance and related laws and regulations, and improves employees' ability to identify compliance risks and awareness of responsibility through case analysis and warning education. The training content is designed in layers based on different job responsibilities and risk characteristics to ensure coverage of directors, senior managers and employees in key positions.

Important issue identification results

During the reporting period, the company conducted a comprehensive analysis of the assessment results of impact importance and financial importance, and presented the overall importance and priority of each issue in a matrix form. In terms of responsibility implementation, the company clarified the specific responsibilities of managers at all levels in compliance and ESG management, emphasizing that the management set an example and took the lead in implementation. A total of 25 important issues were identified, of which 12 issues had a high degree of dual importance. Through performance appraisal and internal supervision mechanisms, we promote the transformation of ESG concepts from "system requirements" to "conscious behaviors" and continue to create an atmosphere of corporate culture of integrity, compliance, and stability.

Figure: Puruis 2025 Importance Issues Matrix

Continuous improvement management feedback

7 Quality Management Internal Supervision 8 Customer Service Daily Execution

23 Compliance operation training and promotion 06 25 Subject protection system formulation 05 6 Innovation drive 04 22Corporate governance system 02

21 Information Security and Privacy Protection 01

20 Business ethics construction 10 Employee training and development

11 Occupational Health and Safety

17 Access to medical care

shadow

Impact 1 Coping with climate change Case Strengthening ESG internal advocacy and promotion, raising employees’ awareness of sustainable development 9 Protection of employee rights and interests

want

12 Diversity, Equality and Inclusion

sex

14 Industry cooperation

15 Public Welfare 13 Sustainable Procurement

During the reporting period, the company integrated ESG concepts with compliance culture, professional

3 Environmental Management 24 Sustainable Development Management 2 Energy Management

5 Waste management 4 Water resources management Combining ethics management with system promotion and training

18 Treat small and medium-sized enterprises equally and continue to promote ESG internal advocacy in a combined manner. Company side

19 Community Building Carry out multi-level publicity and training to directors, management and employees,

16 Rural Revitalization

Integrate business ethics, information security, compliance and other requirements into

Daily management and employee learning system. Through continuous publicity and regular

ESG training has been carried out, and the company has gradually strengthened employees’ understanding of ESG concepts.

understanding and recognition, and promoting sustainable development requires having

Effectively implemented.

financial importance

22 23

Standardize governance

Laying a solid foundation for sound operations

Governance systems and practices 26

Investor Rights Protection 31

Information security protection 33

24 25Purisi (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

4 6 10 2

Governance system and practice

times times times times

Shareholders meeting, Board of Directors meeting, Special committee meeting, Special meeting of independent directors

corporate governance system

Board governance structure and effectiveness

Board Independence and Diversity

Puris has established a corporate governance structure composed of shareholders' meeting, board of directors and management, and strictly follows the "Company Law", "Securities Law" and "Listed Company Governance Code"

The company attaches great importance to the independence and diversity of the board of directors as an important basis for improving the effectiveness of governance and optimizing the quality of risk decision-making. Standardize operations in accordance with the requirements of laws, regulations and the company's articles of association, and continuously improve decision-making, execution and supervision mechanisms to ensure that business and management activities are legal, compliant, transparent and efficient.

As of the end of the reporting period, the company's third board of directors consisted of 9 people, including 3 independent directors, 1 employee representative director, and 1 female director. As the company's highest standing decision-making body, the independent board of directors plays a core role in corporate governance and strategic management. The Board of Directors has Audit Committee, Strategy and Sustainability

Comply with relevant regulatory requirements. In terms of professional background and capability structure, the board of directors maintains a diversified configuration, with members whose professional fields cover medicine, management, law, development committees, nomination committees, remuneration and assessment committees and other special committees. Through professional division of labor, the board of directors improves the scientificity and effectiveness of decision-making and strengthens the

Accounting, ESG and other fields can provide professional support for the company's strategic decision-making, risk management and sustainable development from multiple perspectives.

Improve the board’s professional review and continuous supervision capabilities on major matters.

In terms of sustainable development issues, the board of directors has the corresponding professional capabilities. Some directors hold relevant professional qualifications as senior ESG analysts and are responsible for review by the board of directors. According to the latest requirements of the Company Law and supporting regulatory rules, the company continued to optimize its governance structure during the reporting period and no longer set up a board of supervisors or supervisors. The board of directors will review

Provide professional support for discussing sustainable development strategies, identifying ESG-related risks and opportunities, and carrying out relevant information disclosure work. The composition of the board of directors is diversified, and the planning committee takes over the functions and powers of the original board of supervisors in accordance with the law. By centralizing the supervision function into the audit committee, we further strengthen the supervision of financial reporting, internal control, and compliance.

It helps to improve the overall judgment ability, risk identification ability and decision-making quality of the board of directors, and enhance the forward-looking and robustness of corporate governance.

Supervision of operations, risk management, and performance of duties by directors and senior managers, and promotes the transformation of the supervision mechanism from "formal compliance" to "substantial effectiveness" to achieve

The forward-moving supervision function and closed-loop management provide a solid governance guarantee for the company's steady development.

Board Capacity Building

Figure: 2025 Purisi organizational chart

During the reporting period, the company continued to strengthen the capacity building of the board of directors and continuously improved the duty performance capabilities and compliance governance levels of the board of directors and its members. During the reporting period, the company

Strategy and Sustainability Committee Shareholders Meeting

Through institutional arrangements and practical guidance, directors and senior managers are encouraged to continue to participate in various special trainings conducted by regulatory agencies, industry associations and professional organizations. The training content covers securities market laws and regulations, corporate governance systems, internal control and risk management, environment and social responsibility, sustainable development-related issues, etc.

audit committee

Continuously improve the ability to perform duties and professionalism, and promote the standardized operation of the board of directors.

Board of Directors Office of the Board of Directors

Remuneration and Appraisal Committee

At the same time, the company has established and continued to improve the rules of procedure of the board of directors, the working rules of each special committee, the working rules and decision-making procedures of special meetings of independent directors, and promotes the formation of a closed-loop governance mechanism of "research-deliberation-supervision-feedback" in the decision-making of major matters by the nomination committee, the president's office, the board of directors, various special committees and special meetings of independent directors. Under the overall planning of the Board of Directors Office and the organization and coordination of the Board Secretary, we provide institutionalized and professional support for Board meetings, document management, information disclosure and investor communication to further ensure the standardized and efficient operation of the Board of Directors.

CRO SMO Legal Affairs Government

Ministry of Commerce Human Resources Department Information Technology Department Finance Department Administration Department

Clinical Operations Department Center Management Department Affairs Department

Lin item personnel team capital

Inner bed project S Chuang ITE member team training source and certificate

Review, assist, manage new management assistance, train sub-standard coupons

Department of conditioning

part part heart part part part

department

At the institutional level, the company continues to optimize the governance operation mechanism and further clarifies the composition, rules of procedure, deliberation authority and responsibilities of the board of directors and various special committees.

We will push forward the boundaries of responsibility and promote the decision-making process of major matters to be more institutionalized, standardized and transparent. At the same time, the company continues to improve its risk management and internal control systems and strengthen

System implementation and process supervision provide a solid governance guarantee for the company's stable operations and long-term sustainable development. China Association of Public Companies China Association of Public Companies China Association of Public Companies China Association of Listed Companies 2025 Best Practice Cases of Board of Directors of Listed Companies 2025 Excellent Practice Cases of Boards of Directors of Listed Companies 2025 Listed Company Board Secretary Performance Evaluation 5A Rating

26 27Purimis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

Compliance Training

Compliance operations

The company regards compliance training as an important guarantee for the effective operation of the internal control system and the construction of a compliance culture, and continues to carry out hierarchical and classified training and publicity for directors, senior managers and employees in key internal control system/management positions. During the reporting period, the company systematically promoted compliance training focusing on capital market compliance, business ethics and pharmaceutical industry supervision, and continuously improved the compliance awareness and duty performance capabilities of management and employees.

The company establishes a risk management and internal control system, adheres to the risk-oriented principle, and forms a system covering internal environment, risk assessment, information and communication, control activities and internal control.

A full-chain management framework supervised by the department, and based on business development stages and changes in the external environment, we continue to carry out risk identification and dynamic assessment, and timely adjust risk responses.

In terms of internal training, the company continues to carry out special compliance training for senior managers, focusing on interpreting capital market system strategies through a monthly training mechanism for senior executives.

requirements, information disclosure specifications, legal risks, and financial and internal control risks, and strengthen management’s understanding of compliance responsibilities and risk prevention and control.

The company's internal control and risk management are overseen by the board of directors and its committees. The operating management is responsible for implementing risk management and internal control-related work, and

In terms of external training, the company continues to promote directors and senior managers to participate in compliance and governance topics organized by the stock exchange, the Association of Listed Companies and other institutions to receive evaluation and supervision and inspection by the audit department. The company is engaged in monetary and fund management, sales and collections, human resources management, procurement and payment, project cost budgeting and progress.

Training, strengthen the systematic study of securities regulations, corporate governance, environment and social responsibility and other issues, continue to improve the performance capabilities and standardization of the board of directors and management, fixed asset management, related transaction management, external guarantee management, raised funds management, information disclosure affairs management and other areas to continue to carry out internal control construction

Operational level. Relevant training is carried out in layers based on the responsibilities of directors, senior managers and employees in key positions, highlighting the operational evaluation of capital market compliance and business compliance.

Targeted requirements provide capability guarantee for the company's stable operation and sustainable development.

The company's internal audit system operates under the leadership of the Audit Committee of the Board of Directors. The company has clarified the positioning, responsibilities and authority of the internal audit department through the "Internal Audit Management System".

Work processes and key audit areas, and require internal audit to cover key business links related to financial reporting and information disclosure, and urge closed-loop rectification and follow-up review. Business ethics construction

During the reporting period, the company had no major defects or important defects in the internal control of financial reporting; there were no major defects or important defects in the internal control of non-financial reporting; no

Business Ethics Policies and Measures

There are other significant matters that affect the effectiveness of internal control.

The company attaches great importance to business ethics and integrity and compliance, and continues to improve anti-corruption, anti-bribery and public compliance policies.

level competition system. The company clearly states in its anti-bribery system that “no bribes are allowed to anyone”

Guidelines, covering anti-bribery, anti-corruption, anti-monopoly, anti-unfair competition, anti-money laundering and other requirements,

Case: strengthen the practice of compliance governance through annual anti-corruption self-examination, and provide guidance on gifts and entertainment, funding and donations, facilitation payments (expressly prohibited), third-party cooperation, accounting

Put forward clear boundaries and implementation requirements for key scenarios such as books and records and internal controls.

During the reporting period, the company simultaneously adopted special training materials on business ethics to clarify its policies on corruption, bribery and corruption.

In order to strengthen the company's business ethics and compliance governance, during the reporting period, Puruis organized and carried out annual anti-corruption self-examination work to identify anti-corruption risks.

governance requirements for bribery, conflicts of interest, fraud, money laundering, etc., emphasizing the prevention of unfair competition

It is organically integrated with internal control evaluation and serves as an important part of the company's compliance management system.

prohibitions and the maintenance of fair competition, and incorporate requirements such as the supplier code of conduct into partners

Under management. Relevant business ethics and anti-bribery systems have been promulgated and implemented within the company and passed

During the specific implementation process, the company's internal audit department, based on daily supervision, focused on key businesses such as procurement, sales, fund management, and project approval.

Daily management and compliance promotion are implemented into business practices.

In the financial aspects, conduct systematic inspections on the implementation of internal controls related to directors, senior managers and employees in key positions, focusing on possible causes

Risk situations of bribery and improper benefit transfer, and conduct comprehensive assessments from the dimensions of system implementation, process compliance and employee behavioral standards.

Business Ethical Risk Management

After self-examination, verification and evaluation, during the reporting period, the company found no major corruption or bribery risk matters that need to be reported. The existing anti-corruption management system and

The company incorporates business ethics risks into daily supervision and special supervision systems. The company's internal audit department conducts an annual review of the effectiveness of the internal control system to prevent the overall operation of internal control measures from being effective. The relevant results provide an important basis for the company to continue to improve business ethics management and risk prevention and control systems.

And timely discovery of corruption and bribery risks; risk identification dimensions include motives/pressures, opportunities and attitudes/excuses, etc., and from the perspective of governance structure, institutional setup, and compliance review, the company combines self-inspection findings and management evaluation results to put forward continuous improvement requirements for the implementation of the anti-corruption system and compliance publicity work, and further forms a risk prevention and control framework in terms of planning, system construction, training, and reporting supervision. During the reporting period, the company combined annual internal control and audit work to strengthen employees' compliance awareness and risk prevention capabilities in key business areas, promoted the regular implementation of anti-corruption management requirements in daily operations and management, and continuously consolidated the company's stability by carrying out business ethics risk identification and verification.

governance foundation for sound operations and sustainable development.

The company has set up a standing mechanism for compliance and internal audit, which clarifies the responsibilities of the compliance department and internal audit department in accepting reports, organizing investigations, proposing handling and accountability suggestions, carrying out publicity and annual risk assessment, and ensuring the compliance and traceability of business development through SOP systems and key process controls.

28 29 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

business ethics training

Case: Operational practice of multi-channel reporting and feedback mechanism in compliance management

The company conducts compliance, anti-corruption and business ethics training for all employees, promotes and implements the system through ERP systems, internal training platforms and other channels, and combines it with real

We carry out warning education based on real cases to strengthen employees’ understanding of the legal consequences and compliance red lines of bribery and corruption; the company also carries out targeted education based on department responsibilities and business characteristics.

Focusing on the established multi-channel reporting and feedback mechanism, the company continues to promote institutionalized operations in compliance management, conducts business ethics, compliance operations and targeted training to improve risk identification and response capabilities in key positions.

Information security and other matters are continuously supervised, and are uniformly accepted, investigated and tracked by the compliance and internal audit departments, and relevant results are incorporated into internal management improvements.

During the investigation process, the company focused on the compliance risk points involved in the incident and the weak links in the management process, and formed an internal case after completing the verification. It carried out anti-corruption training for all employees and strengthened the prevention and control of pharmaceutical compliance risks.

Provide improvement suggestions and promote further improvement of relevant management requirements at the institutional and implementation levels. Through the continuous operation of this mechanism, the company continues to strengthen

The ability to identify and respond to compliance risks improves the effectiveness of overall governance.

During the reporting period, the company combined with the compliance regulatory requirements of the pharmaceutical industry to

The above-mentioned mechanism has enabled the company to move further from "system compliance" to "effective operation". Compliance management has shifted from post-constraints to ex-ante prevention and control and continuous supervision. It serves as an important starting point for the construction of sound economic ethics and business ethics management, focusing on anti-corruption,

Provide institutional guarantees.

Integrity, compliant performance of duties and behavioral norms are organized for all employees

Conduct anti-corruption compliance training.

The company focuses on business ethics, anti-bribery and related compliance management systems.

Investor Rights Protection

Uniformly publicize and implement professional ethics and compliance performance requirements, and combine them with the pharmaceutical industry experience

Business characteristics and typical cases, common compliance risks and performance responsibilities in the industry

The company adheres to the investor-centered concept, adheres to high standards and high quality to promote information disclosure, continuously deepens mutual trust and interaction with the capital market, and effectively explains boundaries, professional conduct standards and the consequences of improper behavior to help

Protect the legitimate rights and interests of investors, and strive to build the company into a high-quality listed company that regulatory agencies can trust, the capital market favors, and investors have long-term trust.

Help employees improve their identification and understanding of commercial bribery risks and compliance risks

level, and guide all employees to standardize their duties in the process of business development and operation management.

professional conduct, and consciously follow the principles of honest work and compliant performance of duties. corporate governance system

By continuing to promote anti-corruption and compliance training for all employees, the company continues to strengthen the company's strict compliance with the "Company Law", "Securities Law", "Listed Company Governance Code" and "Shenzhen Stock Exchange Listed Companies Self-Discipline Supervision Guidelines No. 2 - Employee Professional Conduct and Compliance Awareness, Promote the Integration of Business Ethics Requirements into the Standardized Operation of GEM Listed Companies" and other laws, regulations and regulatory requirements, perform information disclosure obligations in accordance with the law, continue to improve the standardization and transparency of information disclosure, and daily operation and management. The relevant training content has been used as internal compliance promotion and maintenance Committed to building a transparent and standardized governance system. In accordance with the "Information Disclosure Management System", the company continues to carry out important components of continuing education through information disclosure media that meet the conditions stipulated by the China Securities Regulatory Commission. Adhere to the orientation of investor needs, continuously improve the accuracy, timeliness and effectiveness of information disclosure, actively convey the company's value, and ensure that all investors have equal access to information. During the reporting period, the company disclosed 145 announcements in accordance with regulations through the media www.cninfo.com.cn, which meets the conditions stipulated by the China Securities Regulatory Commission.

At the same time, the company has improved the "Insider Information Insider Registration and Management System" and the "Information Disclosure Management System" to strengthen the management and confidentiality requirements of inside information, and maintain the principle of fairness in information reporting/complaint management and disclosure and market order.

The company has established a multi-channel reporting and complaint mechanism, set up anonymous mailboxes and provided complaint and feedback communication forms in the office system, covering corruption and bribery, conflicts of interest,

The company's information disclosure quality has been recognized by regulatory agencies and the capital market, and was awarded the highest rating for information disclosure by Shenzhen GEM listed companies for the first time in 2024-2025 regarding employee rights, discrimination and harassment, information security and other matters; the company implements confidential management of reported information and encourages reporting of inappropriate behavior, promoting the formation of "discovery-feedback-

"A" grade, and won the "Golden Bull Award for Listed Companies - Golden Letter Disclosure Award" from the China Securities Journal for two consecutive years, which further reflects the company's governance closed loop of information disclosure compliance, investigation-rectification-review".

Continuous improvement in standardized operation levels and transparency.

30 31 Puruis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puruis ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

The company adheres to the concept of sharing development results with investors. Since its listing, the company has continued to implement a cash dividend policy and distributed a total of RMB 52.4659 million in cash dividends. At the same time, investor relations management

Based on recognition of the company's intrinsic value and long-term development, the actual controller sent positive signals to the market through two share increases. During the reporting period, the company formulated and attached great importance to investor relations management. Through shareholders' meetings, performance briefings, organizing online/on-site investor surveys, and setting up the official website "Investor Relations" to implement market value management related systems, it further improved the investor relations management and value maintenance mechanisms to promote the company's long-term and steady development.

Columns, investor hotlines, e-mails, interactive platforms, etc., build and continue to improve diversified investor communication channels, and maintain timely and interactive communication with investors.

Good communication of letters.

Standardize related party transactions

During the reporting period, the company continued to improve the related-party transaction governance system, perfected and implemented the "Related-party Transaction Decision-making and Management System", and clarified related-party identification standards, related-party transaction types and basic principles. The company updates and reviews the "Control List of Related Parties and Related Party Enterprises" every month, and incorporates identification of related transactions into online ERP form approval

Host meetings Disclose information Respond to Q&A

procedures to reduce the risk of omissions in the disclosure of related transaction information; submit related transaction matters that meet the disclosure standards to the board of directors or shareholders' meeting for approval, and perform related transaction performance explanation meetings, offline visits and receptions, regular reports, temporary announcements, the company's official website, official email, investor hotline

decision-making procedures and information disclosure obligations to meet compliance requirements.

At the same time, the company has also set up prohibitive clauses and supervision mechanisms for high-risk matters such as capital transactions, non-operating occupation, guarantees and related transactions, and clarified the board of directors’ review

Investment interaction

comply with the legal obligations and internal inspection requirements of the planning committee and management, and strengthen the protection of capital security and transaction fairness.

Investor hotline: 021-60755800

Email: [email protected]

Address: 23rd Floor, World Trade Building, No. 500 Guangdong Road, Huangpu District, Shanghai

Information security protection

In the context of the dual-wheel drive of digitalization and intelligent technology, information security constitutes a core element of corporate governance effectiveness and sustainable operating capabilities. During the reporting period, the company responded to 64 investor questions through the interactive platform, with a response rate of 100%; received 135 investor surveys; and held performance briefings

It was fully integrated into the overall ESG risk management framework, and by coordinating the synergy of governance, compliance and digital transformation, it continued to strengthen the security system of the information system once, held three performance communication conference calls, and disclosed 13 investor research activity records in compliance with regulations. The company has set up an investor relations column on its official website to maintain smooth communication

and the protection of the rights and interests of stakeholders.

Open investor communication channels to facilitate small and medium-sized investors to participate in investor relations activities and ensure fairness and consistency in communication.

Protect shareholders’ rights and interests Information security risk management

█ The company always regards the interests of shareholders as an important guide for value creation, implements a scientific, sustainable and stable dividend policy, and strictly follows the "Articles of Association". The company adheres to the principle of "risk orientation, governance first", establishes an information security risk management mechanism covering the attention of the board of directors, management coordination, and implementation by business departments, as well as shareholder return planning, and actively adopts a cash-based profit distribution method to continuously reward shareholders. Unified management of information security risks as an important component of the company's overall operating risks.

Maintaining investors’ right to know, embedding risk management at the governance level, fully managing information security and management, rational principles, body certification

System certification certificate

Registration number: 00335500112255IISS3300887733RR11MM

The company incorporates information security risks into the perspective of corporate governance and compliance management, and through institutional systems and management processes

Zizi proves it clearly

█ True, accurate, complete, timely and fair disclosure of relevant information increases the company's transparency and protects investors' right to know. Pupurui Zhusisi Registered address ((Address: Haihai, Shanghai)) Municipal Medical Hospital Huangyaoyao Pu District Keke Sijiji Nankaikai Road 1 Fafa 05 Shares No. 1 Building No. 1 Co., Ltd. Room 08 Company procedures, clarify the responsibilities of the management and relevant functional departments in the identification, assessment and disposal of information security risks Unified social credit code: 913100000625748002

The management system is in compliance with the requirements

IISSOO//IIEECC 2277000011::22002222 "Information Security, Network Security and Privacy Protection, Information Security Management System Requirements"

boundaries to ensure that information security risks are continuously paid attention to and effectively managed.

Certificate The scope of coverage covered by the certificate

Information security management activities related to SSMMOO services in the pharmaceutical field; "Applicability Statement" ((version number: VV22..00)) ((Border:: 2233 World Trade Center, No. 550000 Guangdong East Road, Huanghuangpu District, Shanghai, Shanghai)

Floor 22330011 unit))

Improve the internal restraint mechanism to protect investors’ rights and interests

Certificate issuance date: 2200-2255-1100-3300 Valid until: 2200-2288-1100-2299 Systematic risk management framework

█

Standardize and strengthen the relationship between the company and the company's internal transaction information, ensure confidentiality, guarantee the confidentiality of the work relationship, and maintain the decision-making information policy and information disclosure of the company to ensure fairness and fairness.

but.

█

Standards should be maintained to ensure that non-guaranteed business operations are conducted in a standardized and standardized manner, and the capital has a financial effect in preventing and utilizing risks from external risks. Guarantee risk.

The company complies with ISO/IEC 27001 information security management system and national network security and data security related

Sign and issue everyone::

█ Improve the special account storage system for raised funds and strengthen the management of raised funds. Standards, establish information security risk management processes, focusing on information asset identification, risk assessment, risk treatment

establishment and continuous improvement to form a closed-loop management mechanism.

Information Security Management System Certification Certificate 32 33 Puruis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puruis ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Information security protection mechanism

Based on the principle of "comprehensive coverage and no dead ends", the company continues to carry out information asset identification and hierarchical classification management, forming an information asset identification list.

And clarify the identification list of important information assets. During the reporting period, the company built a multi-level information security protection mechanism around "system guarantee, technical protection, process control, and responsibility implementation" and implemented it in coordination with the company's compliance management and digital construction.

Asset scope covers

Institutions and Governance Mechanisms

█ Personnel assets (personnel in key positions) █ Software and system assets (ERP training platform, basic data platform, etc.)

█ Data assets (business data, financial data, clinical/project data, etc.) █ Document assets and intangible assets

During the reporting period, the company has formed a relatively complete information security management system, covering key aspects such as system development, testing, operation and maintenance, changes, electronic signatures, and AI use, including but not limited to:

By quantitatively evaluating assets from three dimensions: confidentiality (C), integrity (I), and availability (A), we clarify the scope of important assets and prepare for subsequent risks.

Information security risk assessment, internal system development and iteration, system test process management, electronic signature change process, AI usage management system evaluation and control measures formulation provide the basis.

Estimation and Management System Demand Management System System Management System

01 02 03 04 05 Risk assessment and disposal mechanism

The company regularly organizes cross-departmental risk assessment teams to carry out systematic risk assessments of important information assets in accordance with established risk assessment plans to identify threats and vulnerabilities. Through clear division of responsibilities, approval processes and responsibility traceability mechanisms, we ensure that information security requirements are implemented throughout the entire business process. nature and potential impact, and form an information security risk assessment report.

In response to the risks identified in the assessment, the company formulates and implements an information security risk treatment plan in accordance with the principles of "avoid, reduce, transfer, and accept", through technical control,

Technical protection and system security control

Management controls and operational controls reduce risks to acceptable levels.

At the technical level, the company combines business characteristics and system importance to implement a number of security control measures to reduce security risks during system operation and data processing: after the risk treatment is completed, the company re-evaluates the remaining risks and forms an information security residual risk assessment report to ensure that the remaining risks are confirmed by management and

Controllable state. Access control and permission management system security testing

Implement hierarchical authorization based on job responsibilities to prevent unauthorized access and strictly implement functional testing,

Continuous monitoring and improvement

Abuse of privileges. Performance testing and security testing.

The company combines the results of internal audits, system testing, penetration testing and compliance inspections to dynamically optimize information security risk management measures and continue to improve information security.

Full management maturity provides support for the company's stable operations and digital development.

Penetration testing and vulnerability rectification Data backup and recovery

Regularly conduct third-party penetration tests for key business systems, implement regular backups of important systems and data, and reduce security risks such as timely repair of weak passwords and brute force cracking of the system. Risk of data loss due to failure or attack.

Logging and auditing

Keep system access and operation logs to provide basis for subsequent traceability and security audits.

34 35 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Data and Privacy Protection Mechanism Training Content and Focus

The company strictly abides by laws and regulations related to data security and personal information protection, and implements classified and hierarchical protection of sensitive data.

Privacy Information Management System Certification Certificate

protect. Registration number: 00335500112244PPII1100002222RR00MM The company’s information security training content is closely integrated with national laws and regulations, industry regulatory requirements and the company’s internal management system, focusing on information security management.

Pu Ruisisi ((Shanghai)) Medical and Pharmaceutical Science and Technology Development Co., Ltd.

Registered address: Room 108, Building 1, No. 105 Sinan Road, Huangpu District, Shanghai Key areas and high-risk links include but are not limited to:

Unified social credit code: 913100000625748002

The management system is in compliance with the requirements

During the use of AI tools and information systems, it is expressly prohibited to use undesensitized sensitive information, personal information, and non-desensitized information. IISSOO//IIEECC 2277770011::22001199 Standards

Certificate The scope of coverage covered by the certificate

Disclosure of business data input into unauthorized systems or public platforms, and implementation of review and identification management of AI-generated content, statement and statement with ((VV11SS ..MM 11OO)) services ((Services involved in related and related sites) Privacy: Privacy Information Haihai Information Municipal Management Huang Huanglili Pupu Live District Activity Guangguang;; Dongdong "" Lu Lu Privacy 55 Privacy 0000 Suitable Number Use 2233 Sex █ Information security related laws and regulations and national standard requirements, strengthen employees' understanding of compliance boundaries and legal responsibilities.

Floor 22330011 unit))******

Protect against data breaches and compliance risks.

Certificate issuance date: 11-77-2244 █ Information asset protection, data classification and safe use specifications, clarify the protection requirements and use responsibilities of different information assets.

The maximum validity period is up to: 22002277-77-1166 Note

Sign and issue everyone::

█ Basic protection capabilities such as system security operation, password management, and prevention of network attacks and phishing risks to reduce security risks caused by improper human operations.

Emergency response and continuous support

█ AI use compliance, data desensitization and responsibility boundaries to prevent data and compliance risks that may arise during the application of new technologies. The company has established an information security incident response and disposal mechanism and clarified the incident identification, reporting, disposal and review process.

█ Requirements for the identification, reporting and handling of information security incidents and technical weaknesses to help employees understand the discovery and reporting of information security incidents and security weaknesses, improve response capabilities to network attacks, system failures and emergencies, and ensure business continuity and data security.

Privacy Information Management System Certification Certificate

and collaborative processing processes to improve sensitivity and response capabilities to abnormal situations.

Data and privacy protection mechanism

Information security training

The company continuously tracks and evaluates the effectiveness of information security training through training check-ins, training records, assessments and daily work inspections. At the same time, the company combines the training results with information security risk assessment, technical weak point management and information security incident management. The company attaches great importance to employee information security awareness and capacity building for the weak links found in the training, regards information security training as an important basic work for risk prevention and control, and continues to promote the "system + awareness"

Conduct timely analysis and improvement of common problems.

A training system that combines “knowledge + ability”.

After the occurrence or identification of information security incidents and security weaknesses, the company combines the results of incident handling and cause analysis to optimize relevant training content, strengthen the promotion of key risk scenarios and operational links, and promote employees to better understand and implement information security requirements in actual work. By continuously improving training content and

Hierarchical classification training mechanism

In this way, the company continues to improve employees' information security awareness and practical capabilities, providing stable talent and awareness guarantees for the effective operation of the information security management system. The company has established a hierarchical and classified information security training mechanism based on employee job responsibilities and the sensitivity of exposure to information assets to ensure that the training content is consistent with actual risk scenarios.

The scenery matches.

Case: Conduct information security training in different layers to enhance all employees’ data and technology compliance awareness

During the reporting period, the company carried out coverage around data security and personal information protection requirements.

Information security training for all employees, and differentiated arrangements for risks in different positions.

For all employees, focus on strengthening basic awareness of information security, data protection standards and

Security incident identification and reporting requirements; for information technology and key position personnel, the results

For all employees, carry out basic training on information technology, compliance, management, etc. Integrate the information security requirements system into new employees

Combine system security, authority management and AI usage scenarios to carry out compliance operations and risk prevention

Information security and data protection training focuses on personnel in key positions, combined with special agent induction training and annual regular training based on their responsibilities.

Standard training. Through continuous training and promotion, the company continues to improve employees’ awareness of information security

Strengthen information security compliance awareness and individual points, carry out system security and technical vulnerability plans, and promote information security awareness in the organization

and technical compliance level, and promote the effective implementation of relevant requirements in daily work.

Personal information protection requirements and daily operation point management, risk assessment, and data protection are continuously transmitted within the organization to form long-term stability.

Standardize and improve employees’ special training on information security risks and AI usage compliance to strengthen the foundation of security culture.

Ability to identify and prevent risks. Manage high-risk scenarios and critical control points

During the reporting period, through the collaborative construction of systems, technology and personnel capabilities, the company has formed information security governance capabilities that match its business scale, providing understanding and execution capabilities for clinical research.

Provide a stable and auditable protection basis for research data, personal information and business information.

36 37

Quality Innovation

Create a moat for market competition Clinical trials are the "core cost link, speed-limiting link and quality link" of pharmaceutical research and development. The quality of execution directly determines trial progress and data reliability. Puruis takes regulations and international guidelines as the criterion, uses the standardization system as the starting point, and uses digital intelligence capabilities as the engine to precipitate quality management capabilities into core competitiveness that can be replicated and output on a large scale, and further extends to third-party quality services and industry co-construction, and continues to consolidate the "moat" of market competition.

Strengthen service quality 40

Responsible Marketing and Service 42

Build innovative competitiveness 45

Subject protection 49

Building a sustainable supply chain 52

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quality activities

Strengthen service quality

Purisi quality control closed-loop management

Quality System The company uses PDCA as the basic method to carry out internal quality control activities on a regular basis, forming a closed-loop management mechanism of "plan-execution-tracking-review": formulate quality control plans and initiate unplanned quality control as needed; implement quality control according to unified standards and form quality control reports; continuously follow up on rectification and progress through ERP forms; conduct attribution analysis on high-frequency issues and formulate improvement and preventive measures to promote continuous iteration of SOP:

The "Good Clinical Practice (GCP)" and supporting regulatory documents issued by the State Food and Drug Administration and the National Health Commission regulate clinical trials in subject areas.

Plan (P) Execute (D)

Clear requirements have been put forward in terms of protection of the rights and interests of testers, data authenticity and reliability, and whole-process quality management; "Measures for the Supervision and Inspection of Drug Clinical Trial Institutions (Trial)

"(Practice)" further strengthened the supervision of the operation of the quality management system of testing institutions and related service providers.

Develop quarterly quality control plans, project quality management plans and implement quality control according to project standards, form quality control reports and report to executors

Initiate unplanned quality control based on project requirements. Quality Rating.

During the reporting period, the company continued to adhere to the "Good Clinical Trial Practice for Drugs (GCP)", "Good Clinical Trial Practice for Medical Devices" and "Good Clinical Trial Practice for Drugs".

Institutional Supervision and Inspection Methods (Trial)" and ICH GCP and other regulations and international guidelines are used as the quality management baseline, and the company is evaluated through the Standard Operating Procedure (SOP) system.

The company implements standardized management in daily operations and project execution, and continuously improves the system dynamically based on practical project experience, quality data analysis and regulatory feedback.

Check (C) Improve (A)

Ensure quality management requirements throughout the entire clinical trial execution process.

Follow up monthly on quality control ERP forms and improvement progress. After summarizing high-frequency problems and forming improvement plans and preventive measures, the company combines quality management requirements with personnel capacity building, quality training and digital intelligence tools, and through the coordinated operation of systems, processes and capabilities,

Enter SOP and continue iteration.

Promote the transformation of the quality management system from "compliance-oriented" to "built-in quality".

Puris third-party quality control and audit services

From "system collection" to "running system"

The company's efficient internal quality management system has also been tested through external multi-party verification. During the reporting period, the company needs to accept the approval of pharmaceutical companies before undertaking projects (during the reporting period, the company completed the upgrade and release of the "Quality Manual Guideline v07" and used it as the programmatic document of the quality management system, including quality policy,

Cooperation can only be carried out after passing the review and being included in the list of qualified suppliers.

Quality objectives, organizational structure, responsibilities and authorities, resource management, process management, quality supervision, training management, document management, problem management and CAPA, system audit

Systematically integrate key elements such as inspection, quality control management and project risk management.

On this basis, the company has extended its mature internal quality management capabilities to third-party quality control and audit services that can be provided externally:

The quality management system uses SOP and Policy as specific carriers to clarify the system revision, approval and release mechanisms to ensure that the system is continuously controlled and its operation is traceable. At the same time,

Through problem management and continuous improvement mechanisms, the company incorporates internal quality control, audits, training feedback and quality data analysis results into system optimization, and promotes quality manuals, third-party quality control, and third-party audits.

and supporting systems are constantly iterated.

By reviewing the original test documents and data, verify that as an independent third party, the process, system and test documents

Carry out systematic inspections on process compliance, data integrity and subject rights to ensure compliance with relevant laws and regulations. Quality management requirements are implemented in specific business scenarios through systematic training, document management and supervision mechanisms, and promote quality requirements from "system level" to "daily execution".

interests protection situation. Research protocol and sponsor SOP requirements. Transformed into "operational standards" to ensure the consistency and stability of the system in the implementation of multi-center projects across the country.

As of the end of the reporting period, the company's third-party quality control and audit service team has formed a nationwide layout with more than 50 team members. The average auditor experience is more than 10 years,

Puris SOP system

The average experience of quality controllers is more than 8 years, covering 27 cities across the country, and can quickly respond to the needs of multi-center projects.

Under the framework of the quality management system, the company has formed an SOP system covering more than 330 institutional documents, which provides daily operational management for the management team and front-line employees.

Provide a unified and clear operational basis for management and project execution management, provide targeted support for different business models and project types, and ensure execution consistency and quality. During the reporting period, the company has upgraded quality management from a "system collection" to a "running system", and has moved quality management forward through digital and intelligent means to ensure quality stability. Quantitative capabilities have become the core competitiveness that supports large-scale delivery and high-complexity project execution.

40 41 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

PuriS Verification Assistance Service

customer service

In compliance with the concept of "risk-oriented, built-in quality" in domestic and foreign regulatory trends, the company continues to expand clinical trial verification assistance services based on years of project execution experience.

During the reporting period, the company adhered to the "customer-centered" service concept, built a customer communication and service management mechanism covering the entire life cycle of the project, and formed a "pre-inspection + compliance review" approach to improve verification resilience.

Closed-loop management of "requirement identification - solution design - process communication - problem response - review and improvement": taking customer needs as the starting point to formulate customized service plans, clarifying the communication mechanism and information synchronization requirements for key project nodes; during the project execution process, continue to track service delivery quality and customer feedback, and promote the implementation of improvement measures. Before the verification, the company assisted the project team to systematically sort out key data and documents, identify potential dispute points in advance, and review to form a compliance logic chain; during the verification process,

Through standardized support processes, the efficiency of verification communication and response quality are improved, helping projects smoothly pass regulatory verification.

In order to enhance service experience and predictability, the company continues to optimize service processes and communication methods, emphasizing improving the clarity of information transmission and response efficiency from the customer's perspective. For example, by optimizing the content presentation of project progress reports, problem feedback processing processes and project closing processes, customers can understand the project status in a more timely and comprehensive manner. As of the end of 2025, the company has accumulated a total of: and problem resolution progress.

329 15 5

In terms of customer feedback and complaint management, the company has formed a standardized mechanism covering acceptance registration, investigation and verification, treatment plan formulation, rectification implementation, feedback and classification.

file review and other key links, and incorporate service quality performance into the performance appraisal and incentive and restraint mechanisms to promote the management of "improving experience - reducing errors - continuous improvement" NMPA inspection FDA inspection EMA inspection

Realize your goals.

No major findings were found

Complaint acceptance and registration, investigation and verification, treatment plan formulation and time-limited implementation, feedback and closed-loop archiving. Urgent complaints (involving the safety or rights of subjects) require an initial response within 24 hours. General complaints take 3-5 working days to complete the investigation and formulate

rectification plan; at the same time, we adhere to the principle of confidentiality and fully protect the legitimate rights and interests of complainants and subjects.

Responsible marketing and service

responsible marketing

In order to build service capabilities, the company continues to improve the training system, covering three levels of induction training, on-the-job training and special training. The training focus is closely integrated with the actual service work, including GCP and regulations, project management, communication skills and problem solving, etc.; new employee induction training sets up systematic courses, focusing on covering the company's "compliance, authenticity and transparency" as the basic principles of market communication and business development, and adheres to laws, regulations, industry rules

GCP, relevant regulations, SOP requirements and job operating specifications to help them quickly master job skills and service specifications.

Conduct business for the bottom line in compliance with internal SOPs and ensure that marketing activities and service delivery operate within the same compliance framework. The company believes that

The promotion of clinical research services is not only a commercial behavior, but also a professional exchange closely related to public health interests. It should be based on scientific and

Compliance In service practice, the company continues to summarize common problems and management experience in project execution, and transforms them into project management guidelines, training content and SOP optimization to present service capabilities and project experience in an objective and verifiable manner to avoid exaggeration or misleading.

Compliance

Input is used to support the continuous improvement of multi-center projects in aspects such as execution coordination, progress management and problem response.

In the context of clinical research services, the company strictly distinguishes the boundaries of responsibilities and clearly does not engage in any medical judgment work or falsify data +

data, do not accommodate irregularities in clinical trials, and implement the value orientation of “earning professional respect with professionalism” throughout business development,

The entire process of project execution and customer communication.

true

In order to improve the enforceability and consistency of responsible marketing, the company has established a marketing content compliance management mechanism, and external communication materials are based on Real

The level of sensitivity is subject to graded review: regular publicity content is reviewed and released by relevant business departments; it involves project data, customer reviews,

Sensitive content such as comparative propaganda will be included in the legal compliance review and the approval level will be upgraded; major cooperation or important external information will be managed by

Release after prudent decision-making at all levels to ensure that external information is true, accurate, appropriate and traceable.

At the same time, the company adheres to the principle of fair competition and follows competitive behavior compliance guidelines in bidding, business negotiations, industry exchanges and other occasions:

Transparent

You can objectively introduce your own strengths and characteristics, but you are not allowed to make inappropriate comparisons; you can show your project experience and professional capabilities, but you are not allowed to Transparent

It may not be fictitious or exaggerated; it may seek business opportunities, but must not violate business ethics and legal and regulatory requirements.

42 43Purimis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

Research center (researcher) collaboration

Build innovative competitiveness

Based on the researcher's authorization, the company assists researchers in the research center to carry out on-site clinical trial execution work, and is strictly limited to transactional support of a non-medical judgment nature.

Including ethical material preparation, subject appointment and follow-up, original information and data entry, adverse event statistics, research document management, drug and material management, and more

R&D system and core technology

The hospital coordinates and cares with the center, etc., to help clinical research projects advance with "high quality and efficiency" in the hospital.

As a big data-driven clinical research service provider, Puruis focuses on the entire clinical trial execution process and continues to build a system with data, systems and methodologies as the core. In order to improve the consistency and traceability of cross-center collaboration, the company incorporates research center collaboration requirements into systematic management: strengthen flow through training and Site SOP guidelines

The R&D system deeply embeds technical capabilities into quality management and project execution, forming a core technical foundation that supports the company's long-term competitiveness.

process consistency, and implement unified requirements in terms of file and data management (such as processing of private information of external documents, converting to PDF when necessary, encryption of confidential documents and rights

limited control, hierarchical authorization management based on TMF, etc.) to support the standardization of research document management and risk prevention and control.

Data-based execution modeling system

The company also actively participates in the construction of industry self-discipline and standards, transforms front-line practical experience into industry consensus, and promotes the improvement of clinical research service quality. For example, company parameters

Relying on the execution experience of thousands of clinical trial projects in the past, the company continues to improve the clinical trial execution modeling system, forming industry standards and capability evaluation requirements covering site selection, launch, preparation and promotion of clinical research services, and incorporating them into internal training and management practices to promote research centers and SMOs.

Model capabilities in key aspects such as enrollment, risk and quality. This system makes collaboration boundaries clearer, execution more consistent, and quality risks more controllable by analyzing the central performance, start-up efficiency, entry rhythm, and quality of historical projects.

Systematic analysis of quantitative performance provides quantitative support for pre-clinical trial decisions, reduces reliance on personal experience, and improves the scientificity and predictability of project execution strategies.

Multi-center collaboration and quality monitoring core system

Focusing on the industry pain points of high complexity in multi-center clinical trial execution and difficulty in collaboration, the company continues to strengthen platform-based and systematic R&D, forming core technical capabilities represented by a center-initiated innovation platform and a multi-center collaborative quality monitoring system. Relevant systems realize continuous monitoring of multi-center startup, execution and quality status through standardized processes, unified data interfaces and process traces, providing technical support for forward quality management and risk warning.

Core technical achievements and intellectual property rights

Certificate No. 7781003

Patent announcement information

Invention patent certificate

On the basis of continuous investment in R&D, the company has formed core technologies with independent intellectual property rights.

Title of invention: Technical achievements of a database-based multi-center collaborative execution project quality monitoring system. During the reporting period, the company’s relevant technologies were awarded invention patents by the State Intellectual Property Office.

Patentee: Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd.

Address: 23rd Floor, No. 500, Guangdong Road, Huangpu District, Shanghai, 200001

Patents, including technologies related to adverse event grade determination and multi-center collaborative quality monitoring system, inventors: Yang Hongwei; Chen Xia; Xu Tong

Patent number: ZL 2024 1 1071364.9 Authorization announcement number: CN 118863662 B further consolidates the company's technical barriers in the field of clinical trial quality management and execution. Patent application date: August 6, 2024 Authorization announcement date: March 7, 2025 Applicant on the application date: Purisi (Shanghai) Pharmaceutical Technology Development Co., Ltd. Inventor on the application date: Yang Hongwei; Chen Xia; Xu Tong

The State Intellectual Property Office shall conduct an examination in accordance with the Patent Law of the People's Republic of China, decide to grant the patent right, and make an announcement. In terms of intellectual property rights, the company continues to promote technology research and development and form independent results. Patent rights take effect from the date of authorization announcement. Legal information such as the validity of patent rights and changes in patentees shall be subject to the records in the patent register.

Director

Among them, focusing on the handling of security incidents, the company has obtained the national invention patent "An Undesirable Thing Shen Changyu"

Authorized by "Piece Grade Determination Methods, Electronic Equipment and Storage Media" on March 7, 2025; during the reporting period, the company was in many Page 1 of 1

2024110713649

In the field of project quality management of the center, a new national invention patent "Database-based Multi-center

Collaborative Execution Project Quality Monitoring System" (authorization announcement date: 2025-03-07).

Patent certificate

1 Research center (investigator) collaboration means that the company, under the authorization of the sponsor and the leadership of the researcher, provides the research center with non-involving services around clinical trial site execution.

As well as transactional, managerial and technical support for medical judgment, through standardized processes and clear boundaries of responsibilities, it helps clinical trials to be compliant and controllable. The above technologies are respectively oriented to the standardization and accuracy improvement of safety event processing, as well as real-time collaborative monitoring and early warning of the quality of multi-center projects, to promote high quality under high-complexity projects. Purpose quality stability and risk prevention provide support.

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Case: Reconstructing clinical trial quality management methods with digital intelligence R&D investment

The company always regards R&D investment as an important guarantee for improving service quality and maintaining competitive advantages. In 2025, on the basis of steady growth in overall operating performance, in the company's multi-center clinical trial projects, quality risks often do not originate from a single violation, but from insufficient early decision-making and differences in center recognition. The company continues to increase investment in digital intelligence platforms, data modeling capabilities and quality monitoring systems, providing solid support for quality innovation and management upgrades. Insufficient knowledge and delayed response to abnormal signals during execution. The traditional quality management model dominated by manual experience has become increasingly difficult as project scale expands and

As complexity increases, it becomes difficult to maintain consistency and controllability. On the one hand, solid operating performance provides a financial foundation for the company's continued research and development. During the reporting period, the company's operating income and profitability maintained growth, creating conditions for system research and development, technology iteration and talent investment. On the other hand, the company continued to invest resources in platform functions focusing on key quality risk points in the execution of clinical trials. During the reporting period, Puruis took "digital intelligence" as an important starting point for upgrading the quality management system. It is no longer just an efficiency tool, but is used for optimization, algorithm model upgrades, and improvement of system stability and security to ensure that research and development results can run stably in actual projects and generate long-term value. Reconstruct the decision-making logic and responsibility boundaries of quality management, and promote quality management from "relying on personal experience and judgment" to "based on data and system constraints".

"front-end management" transformation. During the reporting period, the company invested 38.7711 million yuan in R&D, accounting for 4.60% of the current year's operating income.

Through continuous and focused investment in R&D, the company has gradually realized the transformation from "tool construction" to "system capability construction", making technology research and development truly serve quality. In the pre-project launch stage, through systematic analysis of historical execution data, center selection, startup rhythm, grouping expectations and potential quality

long-term goals for quantity management and project execution.

Risks are incorporated into a unified quantitative assessment framework, transforming key decisions from "empirical judgments" to "evidenced choices."

In the connection stage between project start-up and execution, the documents, processes and node requirements required for multi-center start-up are solidified through a platform approach, and the original high-level

Matters that rely heavily on manual coordination are transformed into standardized processes that are traceable and verifiable, reducing execution deviations caused by personnel differences.

Innovation strategy and practice

During the project execution, through the accumulation of system traces and process data, objective basis is provided for subsequent quality review and continuous improvement, forming a "decision-making process".

The company incorporates innovation into the integrated strategy of "quality-efficiency-compliance" and forms a closed loop of innovation ecosystem: policy-execution-review" through institutional incentives, talent training, industry co-construction and system certification.

Through the above methods, the company has gradually realized three changes in quality management:

Innovation incentives and compliance protection

Formulate the "Purisi Invention Patent Award Management Measures" to clarify patent ownership, application process, confidentiality obligations and phased awards

Incentive mechanism to promote timely declaration and standardized transformation of innovation results.

Quality management has been moved forward, responsibility boundaries have been clarified, and management replicability has been improved.

Talent and Capability Building

Risk and quality concerns are determined by the execution phase. Each link is clearly defined through systems and processes to reduce reliance on individual experience and provide guidance for planning.

Move forward to the project design and launch phase. Responsibility requirements reduce ambiguity. Provide support for modularization and multi-project parallelization. Through hierarchical and classified training and digital learning platforms, we create a three-dimensional training model of "knowledge + skills + attitude" and

Incorporate key capabilities such as AE/SAE into special training and practical drills to improve front-line quality execution capabilities.

The company uses digital and intelligent means to improve clinical trial execution under the governance and social dimensions.

Exploring stability and quality controllability will help:

Privacy and information security system support

Obtained ISOIEC 27701 Privacy Information Management System Certification (ISO/IEC 27701:2019) and ISOIEC 270012022 to improve internal quality management and reduce systemic quality risks. Research results for the industry to explore data and system support

Information Security Management System Certification (ISO/IEC 27001:2022), providing SMO services with relevant privacy and information security management effectiveness and transparency. potential impacts on results and subject rights. Quality governance provides practical experience.

Provide systematic guarantee for management to further support the integrity, traceability and trust of relevant parties of clinical research data.

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Case: Building quality execution capabilities for complex innovative drug projects

Subject protection

Innovative drug projects, especially ADCs, CGTs, therapeutic nuclear drugs and dual-antibody projects, generally have complex plans, strict inclusion criteria, long follow-up periods,

In related activities involving clinical research, information system support and data processing, the company always adheres to the characteristics of "people-oriented, prudent use of technology, and controllable risks" and high attention to science and technology supervision, and puts forward higher requirements for SMO's implementation standardization and emergency response capabilities.

In accordance with ethical principles, the protection of subjects' rights and interests is regarded as the bottom-line requirement for technology application and business development. Through a combination of system construction, process control and technical guarantee, in 2025, the company will focus on the characteristics of innovative drug projects and strengthen execution capabilities from the three levels of "people + process + tools": Build a comprehensive protection system covering clinical trial ethics, privacy protection and full-process management of subjects.

In the early stage of the project, combined with the experience of previous innovative drug projects, differentiated execution points and risk warnings are formed for different technical routes;

Subject protection principles

During the execution process, through standardized processes and systematic management, we ensure that the execution caliber of multiple centers is consistent and reduce the impact caused by personnel flow or center differences.

coming quality fluctuations;

In clinical research-related activities, the company strictly follows internationally accepted medical ethics principles and my country's current laws and regulations. It must strengthen process control over subject compliance and key data nodes during the follow-up and long-term management stages to ensure data integrity.

Requirements to ensure the dignity, rights, safety and well-being of subjects take precedence over scientific research and commercial interests.

clinical research

During the reporting period, the company participated in a number of the world's first or China's first innovative drug projects that were successfully promoted and successfully launched. The relevant projects were difficult to implement and

The regulatory requirements are at the highest level in the industry, which verifies the company's quality control capabilities in high-complexity projects and is an important component of the company's innovative competitiveness.

In terms of ethical principles, the company refers to and implements the Declaration of Helsinki of the World Medical Assembly.

Helsinki) adhere to the core requirements of informed consent, prudent risk-benefit assessment, and special protection for vulnerable groups.

ethical principles

Basic principles such as human rights protection shall be adopted to ensure that the interests of subjects are the primary consideration in any research activities involving human beings.

At the compliance and operational level, the company's relevant clinical research activities are strictly benchmarked and implemented in my country's "Drug Clinical Trial Quality Control Cases" to promote the standardized evolution of the industry with quality capabilities.

"Good Clinical Practice (GCP)" and ICH-GCP guiding principles, standardize the management of key aspects of clinical trials such as protocol design, ethical review, research implementation, data recording and storage, and ensure that ethical requirements run through the entire process of clinical trials.

With the tightening of supervision and the improvement of customer quality requirements, the SMO industry has entered a stage of centralized development. Small institutions that lack system capabilities are gradually withdrawing.

As a clinical research site management organization, the company strictly defines the boundaries of its responsibilities and appoints clinical trial coordinators. The industry's requirements for leading companies are no longer just "scale", but "auditable and sustainable quality capabilities."

(CRC) Assist researchers with non-medical judgment matters such as preparation and submission of ethical materials and communication with ethics committees

Compliance and Operations

While supporting the smooth progress of research, it also ensures clear ethical responsibility subjects and decision-making boundaries.

During the reporting period, the company systematically upgraded its quality management system based on regulatory changes and customer requirements:

The company incorporates the ethical principles established in the Declaration of Helsinki into its employee compliance and ethics training system, systematically and continuously improves the SOP system, responsibility definition and collaboration specifications covering the entire clinical trial process, and abides by the trial protocol and GCP-related regulations; through

Training and case discussions promote the unified understanding and implementation of relevant requirements at the front-line execution level.

Special training and assessment to ensure that new regulations and new requirements are truly understood and implemented at the front-line execution level; combined with digital and intelligent tools, quality control work

Gradually shift from post-event inspection to in-process monitoring and early warning.

In terms of privacy and data protection, the company incorporates subjects' personal information and research data into a unified information security management system. Against the background of the accelerated concentration of industry resources towards the top, the company's cooperation with well-known domestic and foreign pharmaceutical companies and CROs continues to deepen, and the company continues to deepen its cooperation in customer structure and ordering.

system, through measures such as information asset identification and classification, risk assessment, access control, log auditing and data retention management, single-quality optimization is achieved, reflecting the market's recognition of the company's quality capabilities and long-term strategy, and also the company's own quality capability building,

Protect against unauthorized access, disclosure or misuse. Relevant systems and processes incorporate privacy protection requirements at the design stage to adapt to and promote the development of the industry in a standardized and high-quality direction. Privacy and data protection

Ensure that data collection, processing and storage are consistent with the purpose of the research and follow the minimum necessary principle.

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Subject protection system Subject protection effectiveness

The company has built a multi-dimensional subject protection system covering systems, processes, technology and supervision, and has implemented ethical requirements from "statement of principles" to "executable and auditable". By systematically embedding ethical principles into system design, process management and technology implementation, the company has gradually formed a management mechanism for subject protection that focuses on prevention and is supplemented by control. Practice mode.

Institutional level Process level

In terms of compliance and risk prevention and control

The company's relevant clinical research and system support activities can At the institutional level, the company has formed a system based on clinical ethics standards and information. At the process level, the company implements research activities involving subjects.

Conducted in an orderly manner within the established ethical and legal framework, the company has effectively reduced the leakage of personal information, digital security management system, system development and testing process, pre-ethical review of AI use, in-process compliance monitoring, post-event evaluation and traces

Risks such as misuse of data and system failure due to lack of systems or loss of control of technology on the rights and interests of subjects, provide a management framework supported by the subject hidden management system, and clarify the closed-loop management mechanism of clinical research and system management. Clinical trial protocols and related information

become a systemic risk. Technical guarantee is provided for private and research data security. The boundaries of responsibilities and compliance of all parties in the system development and data processing process must pass ethical review before implementation; during the research process, significant

requirements to prevent technology misuse or ethical risk spillover. Continuously monitor and manage changes, anomalies and potential risks;

After the research is completed, relevant information shall be properly stored in accordance with regulations to ensure that it is

Retrospective. During the reporting period, the company has extended the subject protection requirements from a single clinical link to the entire process of system construction, data management and technology application, forming a scientific and technological ethics governance capability that focuses on prevention and is based on the principle of prudence.

In the future, the company will continue to improve systems and technical measures related to subject protection based on regulatory updates, technological evolution and business development realities, and further consolidate technology.

Technical level Supervision and risk control

Ethical governance foundation to effectively protect the legitimate rights and interests of subjects.

At the technical level, the company has passed computer system verification (CSV). In terms of supervision and risk control, the company relies on information security risk

System testing, security penetration testing and code security auditing, etc., assessment and risk handling mechanisms, and identification of potential ethical and digital issues.

Ensure that information systems used to support clinical research and data management develop targeted control measures based on security risks and review them regularly

The functions, permissions, security and stability are in line with the intended use and risk status, and the level of subject protection is continuously improved.

Reduce the impact on subjects’ rights and data security caused by system defects

Adverse effects.

█ The company has formed a scientific and technological ethics risk assessment mechanism covering policy changes, technology applications and business adjustments.

█ When external regulatory requirements are updated or major changes occur in internal business, risk assessment procedures should be initiated promptly and targeted

Develop control measures or emergency plans for identified high-risk situations;

█ After handling the risk event, organize a review and optimize relevant systems and processes to promote the continuity of subject protection capabilities.

promotion.

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Implementation level

Create a sustainable supply chain

The company combines different business types and industry characteristics to conduct ESG factor inspections and regular assessments of suppliers, covering environmental compliance, labor and employment standards, and business ethics. The company systematically integrates the concept of sustainable development into the entire supply chain management process, focusing on the three levels of system construction, process control, and capacity building to build a supply ethics and governance structure. For suppliers with good performance, we will actively support them in terms of cooperation opportunities and business stability; for suppliers with deficiencies, we will adopt a sustainable supply chain management system for access, cooperation, evaluation and improvement, and continue to improve the compliance, resilience and collaborative value of the supply chain. During the reporting period, the company promoted continuous improvement through communication, coaching and improvement requirements.

Practices in sustainable supply chain management have been recognized by external platforms with a Bronze Medal in the 2025 EcoVadis Sustainability Rating.

In addition, the company has formulated and implemented a supply chain diversity and inclusive cooperation management system, and under the same conditions, actively supports cooperation with small and medium-sized enterprises, women and minority groups to promote the construction of a fair and inclusive supply chain ecosystem. Relevant practices have formed annual summaries and typical cases, providing replicable experience for the development of supply chain diversification and supplier management mechanisms.

During the reporting period, the company established an institutionalized, process-based and hierarchical supplier management mechanism, taking compliance, integrity and sustainable development requirements as supply chain management

basic premise.

Sustainable procurement empowerment

The company formulates and implements the "Procurement Management System and Procurement Process", "Supplier Information Registration and Evaluation Process" and "Supplier Code of Conduct"

During the reporting period, the company not only focused on its own procurement compliance and risk control, but also focused on improving the overall sustainable development of the supply chain and other system documents through training, communication and collaboration, and made clear provisions on supplier access conditions, evaluation factors, contract management and continuous supervision. All suppliers

develop ability.

At the institutional level, information registration and necessary compliance review must be completed before cooperation, and the "Supplier Code of Conduct" must be signed to clarify the requirements for human rights protection, labor

Basic requirements for employment, environmental protection, business ethics, anti-corruption and information security.

On the one hand, the company continues to carry out special ESG training for procurement personnel, focusing on sustainable procurement concepts, supplier responsibility management and compliance requirements, etc., to enhance relevant personnel's understanding and execution capabilities of sustainable supply chains, and to promote the implementation of concepts in daily procurement decisions.

The company implements full life cycle management of suppliers through the information system, covering access assessment, contract performance, performance appraisal and dynamics

On the other hand, the company organizes supplier sustainable procurement training and communication activities to convey sustainable development requirements and management expectations to the partner system to help update. Implement hierarchical management of suppliers based on procurement scale, business importance and risk level, and target high-risk or key suppliers

At the process level, they understand the relevant policy background, compliance priorities and improvement directions. Through training, feedback and continuous communication, the company has formed active interactions with most suppliers and improved suppliers to set more stringent review and supervision requirements to ensure that the cooperation process is transparent, traceable and auditable.

mechanism to promote the improvement of the overall responsibility awareness of the supply chain.

In addition, the company promotes the extension of sustainable concepts to a wider industrial chain by participating in industry initiatives, industry exchanges and industry-education integration projects. The company actively responded to the company's intention to incorporate suppliers' performance and compliance performance into ongoing management, and rectify the identified problems through communication and deadline improvements.

Initiate industry initiatives related to clinical research and participate in industry standards and capacity building; at the same time, through industry-education integration cooperation with universities and medical institutions, support professional talent training and promotion; in cases where basic compliance and integrity requirements cannot be met, corresponding management measures will be taken in accordance with laws and regulations. Through the above mechanism,

Long-term capacity building for the livestock and poultry industry and providing stable talent and professional support for a sustainable supply chain.

Supervision and correction

The company effectively reduces supply chain compliance and operational risks while ensuring procurement efficiency.

Sustainable Procurement Policies and Measures

The company adheres to the principles of quality first, compliance-based, and equal emphasis on responsibilities in procurement decisions, and gradually incorporates environmental, social and governance (ESG) factors into procurement management

and supplier evaluation system.

policy level

The company clearly states in the procurement system that on the basis of meeting quality, cost and service requirements, it will pay attention to suppliers' environmental management, employee rights and interests, compliance operations, etc.

performance in this aspect and promote the implementation of sustainable development requirements in the supply chain. The company sets forth clear and enforceable responsibilities to suppliers through the Supplier Code of Conduct.

Require and encourage them to pass relevant ideas upstream and downstream.

52 53

Care for employees

Create a harmonious social atmosphere

Puruis always regards its employees as the company's most important assets and the core driving force for long-term value creation. On the basis of protecting the basic rights and interests of employees in compliance with laws and regulations, the company continues to improve system construction and management practices around key issues such as occupational health and safety, talent development, diversity and inclusion, and social collaboration, and strives to create a safe, respectful, and inclusive working environment. At the same time, the company actively participates in industry collaboration and social co-construction, and promotes the capacity improvement of the clinical research service industry and the improvement of social public welfare through industry-university-research cooperation, industry exchanges, and public welfare actions, and works together with employees, partners, and all sectors of society to build a harmonious and sustainable development ecosystem.

Employee care and rights protection 56

Social Contribution 72

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Anti-discrimination and anti-harassment

Employee care and rights protection

█ Puris clearly prohibits any form of discrimination and harassment, covering all aspects of recruitment, employment, daily management and employee relations, and implements the "zero tolerance" principle through institutional arrangements. The company establishes a clear code of conduct, clearly defines the boundaries of acceptable and unacceptable behavior to employees, and protects the rights and interests of employees in compliance with laws and regulations.

Continuously create a fair and respectful work environment.

█ In management practice, the company has established a multi-channel complaint and feedback mechanism to encourage employees to report discrimination or harassment, and provide relevant information to the company. It strictly abides by the "Labor Law of the People's Republic of China", "Labor Contract Law of the People's Republic of China" and other relevant laws and regulations. In recruitment, labor contract management,

Maintain strict confidentiality and resolutely prevent retaliation. For complaints received, the company will investigate and take corresponding handling measures in accordance with laws and regulations; in serious cases, the company will adhere to the principles of legal compliance and fairness and justice in terms of salary and benefits, career development and employee relationship management. During the reporting period, the company did not employ child labor or force

For serious cases, a professional legal team will intervene and, if necessary, be handed over to relevant departments for handling. Through training and promotion, supervision and inspection, and continuous improvement, the company continuously prevents labor-related incidents. At the same time, the company refers to the common principles advocated by the United Nations Global Compact (UNGC) and the International Labor Organization (ILO), and integrates human rights and labor.

Strengthen anti-discrimination and anti-harassment management to protect the legitimate rights and interests of employees.

Rights protection is integrated into daily operations and value chain management, and we strive to create a working environment that respects differences, equal opportunities, and an inclusive atmosphere, and supports employees in safety,

Realize personal value in a respectful environment and grow together with corporate development. 04

Fair recruitment and career advancement

At the institutional level, the company incorporates anti-discrimination, anti-harassment, prohibition of forced labor and other requirements into its employee management system and daily operation processes, and clarifies behavioral norms and responsibility boundaries.

█ Puruis adheres to the principles of fairness, impartiality and non-discrimination in recruitment and career promotion management, and prevents discrepancies in recruitment and promotion through institutional arrangements and uses a multi-channel appeal and feedback mechanism to ensure that employees can receive timely and effective relief when they encounter unfair treatment.

When prejudice. The company formulates standardized recruitment policies, clarifies job responsibilities and job requirements, avoids using language that may cause discrimination in recruitment advertisements and recruitment materials, and clearly explains the selection criteria and procedures before interviews to ensure that the recruitment process is transparent and traceable. The company welcomes diversity, equality and inclusion (DEI) talents from different backgrounds to apply. In recruitment, promotion and salary management, no matter race, color, religious belief, gender, sexual orientation, nationality, age, pregnancy or other factors, Puruis attaches great importance to the concept of diversity, equality and inclusion as an important basis for the protection of employee rights and interests and the sustainable development of the organization. Employees or candidates are treated differently based on factors such as disability. The management makes decisions based on objective criteria such as job matching, ability and performance, continues to promote the construction of a diversified talent team, and creates a fair and inclusive employment environment.

Diverse corporate culture

Ban child labor

█ Puruis attaches great importance to the diversified development of its workforce and is committed to creating a diverse, inclusive and equal corporate culture. The company respects employees

Puris attaches great importance to the protection of the rights and interests of minors and strictly abides by the "Labor Law of the People's Republic of China", "Provisions on the Prohibition of Child Labor" and other relevant laws and regulations. Due to differences in lifestyles, customs, beliefs and personal habits, it strives to provide employees with corresponding conveniences without affecting normal operations.

The use of child labor is expressly prohibited in recruitment and employment management. The company implements a standardized and strict review process during the employee recruitment process, and helps employees achieve a better balance between work and life through age information verification and other methods.

Ensure that all new employees meet the national legal employment age requirements to prevent the risk of child labor from the source.

█ In terms of organizational management and team building, the company encourages the reasonable flow of internal personnel, promotes communication and collaboration among employees with different backgrounds, and promotes diversity

Cultural integration and mutual learning. At the same time, Puruis adheres to a "zero tolerance" attitude towards any form of discrimination and harassment. Through institutional constraints and daily institutional and management practices, the company has established a child labor risk prevention and response mechanism. Once suspected child labor is discovered, the company will immediately stop relevant work arrangements and management to maintain a fair and respectful working order. The company advocates candid and open exchanges, and encourages employees to conduct business on the basis of mutual respect and trust, take necessary protective measures in accordance with the law, and report to relevant authorities in accordance with regulations. At the same time, the company will cooperate with relevant departments to carry out investigations and, under the premise of legal compliance, cooperate to give full play to the team's strength and continue to create a united, inclusive and cohesive organizational culture. Provide necessary health examinations, medical assistance and supportive arrangements to ensure that minors receive proper care and have the opportunity to continue their education. Through the combination of institutional constraints and process management, Puruis continues to strengthen child labor prevention management and maintain a compliant and responsible employment environment. During the reporting period, no incidents related to the employment of child labor or forced labor occurred in Puruis.

Diversity training

█ Puruis regards diversity training as an important part of promoting the construction of a diverse and inclusive corporate culture, and carries out relevant training for all employees to help

Employees understand, master and abide by the company's principles and requirements on diversity and inclusion, and standardize the training process and results to ensure

Relevant training records are properly retained. The company continues to improve employees' understanding of the company through various forms such as diversified theme training, special lectures and offline activities.

The understanding and acceptance of members from different backgrounds promotes cross-team and cross-department collaboration and communication.

█ At the same time, the company's management maintains an open and inclusive management attitude, adheres to the principles of fairness and impartiality in performance evaluation and promotion decisions, and avoids potential

Discrimination or prejudice; the company's senior management supervises and guides the construction of diverse culture, conducts relevant internal investigations and evaluations on a regular basis, and based on the evaluation

Based on the evaluation results, we will continue to optimize diversity training and management measures and promote the effective implementation of diversity concepts in the organization.

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Ban forced labor and focus on the rights and interests of female employees

Puruis attaches great importance to the protection of the rights and interests and career development of female employees, incorporates relevant requirements into employee management systems and daily management practices, and continues to create a safe, respectful, and inclusive working environment. The company strictly abides by the "Law of the People's Republic of China on the Protection of Women's Rights and Interests" and other relevant laws and regulations, and clearly prohibits any discrimination or harassment against the will of employees, covering speech, text, images and physical behavior. Through a combination of system constraints and management execution, it effectively protects female employees. Any form of forced labor in the company is clearly prohibited, including withholding employee identity documents, requiring deposits, and dismissal,

Human dignity and legal rights in the workplace.

Penalties and other methods threaten employees to engage in overtime or involuntary work.

Forced labor is explicitly prohibited

Pay attention to women’s development opportunities

Ensure that employees have the right to freely choose their career and work independently in accordance with the law, and ensure that employees will not be punished, threatened or improperly restrained

Forced labor; at the same time, we provide employees with a safe and healthy working environment to avoid forced labor caused by unreasonable working conditions. In recruitment and employment management, Puruis adheres to the principles of fairness, justice and non-discrimination and does not protect the rights and interests of female employees or candidate employees based on gender, reproductive status and other factors. Set limits. During the reporting period, the company recruited female employees who were pregnant or lactating, demonstrating its support for the continuity and diversified development of women's careers. In terms of career development, the company pays attention to the career transition issues of female employees during special stages such as maternity leave. For female employees involved in promotion evaluation, they will retain their corresponding positions and development qualifications in accordance with laws and regulations to ensure that they enjoy fair development opportunities after returning to work.

Regularly conduct anti-forced labor related training and publicity for managers and all employees to improve employees’ awareness of labor rights and compliance

awareness of the requirements and enhance employees’ awareness and ability to safeguard their rights in accordance with the law.

Training and publicity Women’s participation in management and decision-making

█ The company has a relatively high proportion of female employees, and women play an important role in the company's management and decision-making levels. During the reporting period, female executives accounted for more than 70% of the company's management. Female managers continue to contribute professional value in business management, team building and organizational governance, which reflects that the company has established a special complaint and investigation handling mechanism in the management diversification, smoothed the channels for employees to report forced labor, and promptly accepted relevant complaints.

active practice in culture.

And conduct investigations, take necessary corrective measures, and protect the privacy and safety of whistleblowers in accordance with the law.

Complaints and Investigation Mechanism

Focus on women’s self-growth and psychological support

Incorporate anti-forced labor requirements into the supplier management system, conduct regular reviews and assessments of suppliers, and promote all links in the supply chain █ The company pays attention to the actual needs female employees face in career development and life balance, and complies with relevant laws and regulations by organizing female growth-themed reading sharing sessions, exchange activities, etc. to prevent the risk of forced labor.

In this way, we carry out communication and support around issues such as career development, psychological adjustment and self-growth, and help female employees improve their self-awareness and psychological resilience.

Supplier management

Promote their sustainable development in work and life.

Improve women’s care and support measures

Pay attention to vulnerable groups

█ In terms of employee care, the company has set up a number of special examination items for women in the annual health examination to support female employees to pay attention to their own health; during the "March 8th" period, Puruis pays attention to the diverse needs of different employee groups and incorporates the protection of the rights and interests of minority groups into employee management and employment practices. On important occasions such as International Women's Day, we organize caring activities and arrangements based on the actual situation of the company to create a respectful and friendly working atmosphere. At the same time, the company has set up supporting facilities such as maternal and child rooms in the office to provide necessary work support conditions for employees in need, and continues to optimize the work experience of female employees. In accordance with the "Law of the People's Republic of China on the Protection of Disabled Persons", the "Regulations on the Employment of Disabled Persons" and other relevant laws and regulations, and based on the actual situation of the company, the company has formulated and implemented

barrier environment.

Implement the "Work Management System for Disabled Employees" and continue to strengthen the institutional protection of the rights and interests of disabled employees. The company attaches great importance to equal employment and career development of disabled employees.

development, ensure that they enjoy fair and transparent employment conditions in terms of recruitment, salary, benefits and career development in accordance with the law, and pay five insurances and one fund for disabled employees in accordance with regulations.

Effectively safeguard the legitimate rights and interests of employees.

In terms of work support and environmental protection, the company continues to optimize the barrier-free office environment, configure necessary auxiliary equipment and adaptive tools according to job requirements, and improve

Job adaptability and work convenience of disabled employees. At the same time, the company actively connects with relevant resources such as rehabilitation guidance and employment support to help disabled employees better integrate

Join the work team and career development system, and continue to create an equal, diverse and inclusive employment environment. In 2025, companies are taking a more active approach to expand employment opportunities for people with disabilities.

industrial space, and simultaneously build a rights and interests protection mechanism so that every worker can realize the value of life in an environment of equality and dignity. During the reporting period, Puris co-employed

There are 27 disabled employees.

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Case: Pay attention to women’s self-growth and attach importance to women’s groups

The company has more than 90% female employees and attaches great importance to the workplace and life challenges faced by all female employees. With equal promotion and career opportunities, the company pays attention to the self-growth and psychological support of female employees and organizes development paths.

held a reading and sharing session on the theme of women’s growth, focusing on women’s roles in the workplace and life.

Communicate about the pressure faced in life, inward exploration of endogenous power, etc.

Flow and discuss. Help establish a salary Q&A platform by guiding power awareness and sharing ways to reduce stress.

Help female employees improve their self-awareness and psychological adjustment capabilities, and support them

When faced with employees’ questions about salary, actively look for opportunities, patiently answer employees’ questions and resolve their dissatisfaction. Aiming at common problems through intelligent robots, we can achieve better balance and development in work and life.

QA questions and answers. Let employees better understand the company's compensation policy, while enhancing employees' trust and loyalty to the company.

Develop scientific and reasonable compensation policies

Salary and benefits

Puruis regards a fair, transparent and competitive salary and benefit system as an important basis for attracting, motivating and retaining talents, and continues to improve the salary management mechanism in line with the company's development stage. It fully considers factors such as market salary levels, employee performance and abilities, and the company's financial status to ensure that the salary level is equivalent to that of companies in the same industry and matches the segment and business characteristics. The company adheres to the principle of equal pay for equal work, comprehensively considers job responsibilities, performance, ability levels and market remuneration, and matches employees' performance and abilities.

status, establish a scientific and reasonable salary and promotion system, and ensure that employees enjoy fair opportunities in terms of remuneration and career development. At the same time, the company passed clear

Promotion channels, smooth communication and feedback mechanisms and effective supervision arrangements continuously improve the transparency and fairness of salary management and support employees and enterprises to achieve long-term,

Stable common development.

Establish an effective supervision mechanism

Promote salary equality and establish a salary supervision committee, which is composed of representatives of employees and management. It is responsible for supervising the implementation of the salary system and handling employee complaints and reports in a timely manner.

Establish equal pay for equal work as a basic principle

We pay fairly based on position, performance and ability, and regularly monitor and analyze salary indicators to protect the rights and interests of every employee. Ensure employee motivation and employee benefits

Male and female employees with the same position, experience and work performance receive equal pay.

In 2025, the company will continue to improve its employee incentive mechanism. In 2025, the company's welfare management will achieve a milestone and strengthen performance-oriented management. Starting from April 2025, Breaking: Through the precise implementation of diversified welfare measures, the company has implemented a visit bonus incentive plan for all employees, and the satisfaction index in different provinces has significantly improved, corporate cohesion has continued to increase, business execution has been ranked in performance, and strong momentum has been injected into organizational development through visualization. Looking to the future, we have established an employee promotion mechanism and publicity methods to demonstrate outstanding achievements. This incentive measure will take "talent empowerment" as the core, continuously optimize welfare management, effectively enhance employees' goal awareness and work enthusiasm, stimulate the management system, and provide employees with a dual-channel development route of professional channels and management channels through skill improvement plans and quality development projects. A clear job structure has been formulated to ensure the performance evaluation of employees at all levels. Employees continue to maintain good professional status and work enthusiasm, and further Fully activate the potential of employees and promote the company's competitiveness to a new standard. Openness, fair procedures, and open and transparent appointment and promotion of managers at all levels; in addition, an internal job transfer mechanism has been formulated so that employees can further promote the improvement of project execution efficiency and service quality, and help the company reach new heights.

If there is a need for internal job transfer or location transfer based on personal development needs, if there are job vacancies or regional personnel needs, interviews with internal employees will be prioritized. Strengthen the steady development of the company's business.

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Statutory benefits

Type Form Value/Meaning

Social insurance and provident fund, parental leave and paid annual leave, etc.

The company sets up anonymous mailboxes covering all employees

Provide an anonymous grievance mechanism and anonymous suggestion box for employees who encounter discrimination, harassment, unfair treatment or other work issues.

Provide a safe and confidential feedback channel when questions arise.

[email protected]

Health protection benefits Festival and cultural constructive benefits

Supplementary medical insurance, holiday benefits, team building activities, email complaints, and the company has set up a "Complaint Feedback Channel" in the office system.

Ensure that employee complaints are accepted and followed up in a timely manner. Health examination, etc. Spring Festival welfare leave, employee condolences and care, etc. Mechanisms support employees to make non-anonymous complaints through the form

non-anonymous

Employees can also use internal corporate communication tools (e.g.

Achieve instant and convenient feedback.

Such as DingTalk) directly initiate the appeal process

Incentive benefits Life security benefits

Puris employee benefits

The company regularly collects data from employees in different time periods

Reward growth training plan, meal subsidy, transportation subsidy

Suggestions and summaries, such as year-end summaries, will help management understand employee needs in depth and continuously optimize management decisions, Ruixin Award; Ruizhen Award; Ruien Award; Bole Award; Communication Subsidy, High Temperature Allowance; Year-end Summary Feedback Mechanism

At the same level: individual, department, company and other levels to create an open and inclusive organizational atmosphere.

Public rental housing in Huangpu District, Shanghai collects feedback from employees.

Ensure employees have a clear understanding of the company's performance goals and promote

Employee communication

Effective communication between employees and corporate management, thereby improving work KPIs. Regular communication between management and employees.

The company attaches great importance to employee participation in the construction of communication mechanisms, and ensures efficiency and overall performance through various channels such as anonymous mailboxes, internal system complaint forms, instant messaging tools, and regular surveys. It helps employees understand the goals of other departments or colleagues and promotes collaboration and communication across departments or teams. To prevent employees from expressing their demands in accordance with the law and on an equal footing.

Understand employees’ opinions on company management, working environment, compensation and benefits, etc.

Employee Enterprise Satisfaction Questionnaire

In 2025, the company will organize an anonymous survey on employee corporate satisfaction, systematically collect employee feedback on management, working environment, salary and benefits, etc., and summarize their feelings and opinions to identify opportunities for improvement and improve employee

Anonymous research

Results serve as an important basis for management improvement. At the same time, the company strengthens performance dialogue between management and employees through regular KPI communication mechanisms to promote cross-departmental collaboration and job satisfaction.

Improved organizational transparency.

Monthly publication of employees' professional practice results and project experience. By displaying employees' professional contributions and growth practices, it enhances employees' professional experience sharing and staged growth cases within the company. It serves as a platform for employees' sense of identity and organizational belonging, and promotes the internal dissemination of excellent experience. The company's monthly magazine is a platform for communication and experience exchange. Create a corporate culture that respects professionalism and encourages growth.

Grievance process

01 Employees submit complaints through anonymous mailboxes and need to fill in relevant information, including complaint matters, factual descriptions, evidence, etc.

02 After receiving the complaint, the company will arrange a dedicated person to conduct investigation and verification, and promptly respond to the employee's progress.

03 Based on the investigation results, the company will take corresponding measures to solve the problem and ensure that the rights and interests of employees are protected.

04 For serious issues involving violations of laws and regulations, the company will handle them in accordance with the law and hold the relevant responsible persons accountable.

The company conducts continuous follow-up and return visits on the handling results to ensure the effective implementation of rectification measures, forming a closed-loop management mechanism of "grievance acceptance-investigation and verification-handling feedback-tracking improvement" to effectively protect the legitimate rights and interests of employees.

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During the reporting period, the company launched an anonymous survey on employee corporate satisfaction, focusing on company management, working environment, salary and benefits. 95.7% At the cultural and social level, the company combined traditional festivals with employee interests and organized themed cultural activities such as the "Full Moon Mid-Autumn Garden Party". It systematically evaluated employee feelings and feedback through interactive experience, benefits and other aspects, promptly identified room for management improvement, and adjusted team collaboration and cultural sharing through comparison of policies to enrich employees' spiritual and cultural life, and enhance cross-department communication and team cohesion. Relevant activities not only enhance employees' sense of participation, but also provide decision-making basis for management optimization through changes in satisfaction before and after. Employee satisfaction surveys not only provide employees with a measure of performance, but also help create a positive and inclusive organizational atmosphere. It provides a platform for expressing opinions, strengthens the information communication and trust foundation between the company and employees, and also helps to enhance employee loyalty.

2025 Employee Satisfaction Rating

Sense of belonging and organizational cohesion. At the same time, the company strengthens performance dialogue through a regular KPI communication mechanism to ensure that employees

Improved from the previous year

Clearly understand corporate goals and job responsibilities, promote cross-department collaboration, and continue to improve overall operational efficiency.

Case: Convene an employee representative meeting to ensure employees participate in corporate governance

In September 2025, the company held its annual employee representative conference, with 226 employee representatives from various departments participating. The meeting reviewed the "About Elections"

Proposal of the Employee Representative Director of the Company's Third Board of Directors", and after full discussion and voting by the employee representatives present at the meeting, the third session of the Board of Directors was elected in accordance with the law.

Employees on the board of directors represent directors and perform relevant governance procedures. This initiative further improves the institutional arrangements for employees to participate in corporate governance and strengthens

The employee participation mechanism in corporate decision-making and supervision reflects the company's standardized and institutionalized practice in employee democratic management.

Employee care

Puruis adheres to the people-oriented development concept, pays attention to the diversified needs of employees in different career stages and life scenarios, and regards employee care as a way to enhance organizational cohesion.

Family friendly and socially connected

An important starting point for cohesion and sustainable development. During the reporting period, the company continued to promote systematic development in aspects such as physical and mental health, family support, emotional connection and organizational identity.

We adopt unified and normalized employee care measures, strive to create a warm, mutual trusting, and positive working atmosphere, and support employees to engage in work and personal development in a good state. Puruis pays attention to employees' family and social needs outside of work, actively explores family-friendly management practices, and supports employees in a variety of ways to balance work and life.

Physical and mental health and cultural and sports care

Case: Single employee socializing activities The company attaches great importance to the physical and mental health of its employees and integrates the concept of health promotion into daily management and employee activity arrangements. During the reporting period, the company organized the “Vital Workplace

Fitness activities such as "Ba Duan Jin" help employees relieve stress and improve their physical condition during work breaks through professional guidance and lightweight, participatory forms of exercise.

Promote physical and mental balance and raise awareness of health management. During the reporting period, the company actively responded to the initiative of the street trade union, organized and mobilized single employees to participate in spring socializing activities, helped employees expand their social circles, enriched their spare time life, and reflected the organization's care for employees' personal development and happiness.

Case "Vital Workplace Baduanjin" normalized health activity

Case Family Open Day Activities In 2025, the company combined the resources of the street trade union to introduce the tradition of "Vital Workplace Baduanjin"

Health care program, with systematic guidance by professional teachers, helps employees relieve shoulder and neck fatigue,

The company organizes open day activities for family members, inviting family members of employees into the office to improve the physical discomfort caused by prolonged sitting by visiting the working environment, understanding job responsibilities and interacting with each other. The activities are conducted in a zero-threshold, short-term, and easy-to-participate manner

In this way, we can enhance family members' understanding and support of employees' work, further strengthen the emotional bond between employees' families and the company, and create a platform that supports employees' long-term development and integration into their daily work. It is widely welcomed by employees and has gradually become an important part of the company's health care.

A good external environment for development.

components.

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Mental health support and emotional care performance appraisal system

The company attaches great importance to employees' mental health and emotional management, and integrates psychological care into institutionalized management and daily communication mechanisms. During the reporting period, the company established a performance appraisal system covering different positions and levels, guided by job responsibilities and business goals, and formed a performance management mechanism that focuses on employees' psychological state and adaptation status in key performance indicator communication, performance feedback and employee development interviews, and helps employees relieve stress and (KPI) through communication, guidance and care support. The company implements differentiated assessment arrangements based on job types, differences in responsibilities and management levels to ensure that performance evaluation and employees enhance their sense of professional security and belonging. Match the actual work content, professional requirements and development stage of the workers.

On this basis, the company continues to release authoritative resource information such as the national free psychological counseling hotline to employees through all-employee emails and other methods, and actively links with external professional institutions. In terms of performance management processes, the company promotes the implementation of performance appraisal through institutionalized and information-based methods. The performance management team of the Human Resources Department takes the lead in formulating and coordinating the provision of convenient and sustainable psychological support channels for employees, building an employee mental health support network covering internal care and external support, and helping employees maintain good performance indicators for each position. The performance appraisal process is initiated, approved and archived through the internal system to ensure that the appraisal process is standardized and the results are traceable. The performance appraisal cycle establishes good mental state and work resilience. Depending on the nature of the position and the management level, it covers different periodic arrangements such as monthly, quarterly, semi-annual and annual.

The company attaches great importance to the construction of employees' mental health, embeds psychological care into institutional management and daily communication mechanisms, and pays attention to employees' mental states at different stages. The company pays attention to the communication and feedback mechanism of performance management. In the performance appraisal process, it emphasizes two-way communication between managers and employees, through performance goal confirmation, and adaptation status. Methods such as process reviews and result feedback help employees clarify job expectations, identify improvement directions, and use performance results as an important reference for employees' career development and ability improvement.

Performance appraisal results are closely linked to employee incentives and career development, and serve as an important basis for management decisions such as bonus distribution, job promotion, salary adjustment and job adjustment. Case Study Psychological care is integrated into employee communication and management processes

By organically combining performance management with incentive mechanisms and talent development systems, the company continues to guide employees to improve their professional capabilities and work performance, and promote the common growth of the organization and employees.

During the reporting period, the company paid attention to employees’ psychological state and work adaptation during probation period communication, performance feedback and development interviews.

Through timely communication and caring guidance, we help employees relieve occupational stress and enhance their sense of security and belonging. staff training

The company has established a systematic, multi-level employee training system that organically integrates compliance requirements, professional capabilities and career development, covering the entire employee process from entry, on-the-job to promotion.

Case Linkage of External Psychological Support Resources

Training system and course structure

With "Basic + Advanced + Special + Extension" as the core, the company has formed a full-cycle course system covering different positions and development stages:

The company attaches great importance to the mental health of employees and embeds psychological care into institutional management such as probation period communication, performance and development interviews, etc.

management, and create an inclusive and caring workplace atmosphere through mental health promotion and education. At the same time, the company continues to pass all

Publish national free psychological counseling hotline information to employees through employee emails, link with external professional resources, and provide employees with a convenient and employee training course system

Sustainable psychological support, building an employee mental health support network covering internal care and external support.

Type Training Scope

Basic knowledge core compliance courses, basic skills courses

Advancement and promotion: professional courses at different levels, courses for management positions

employee growth

Project-Specific Training Project-specific training for CRC accepted projects

Puruis always regards the joint development of the company and its employees as one of its most important responsibilities, adheres to the talent training concept of "compliance-based, empowering growth", and focuses on clinical development.

We conduct comprehensive research on industry characteristics and employees’ career development needs, build a talent training and development system covering the entire career cycle of employees, and continuously improve employees’ professional capabilities and organizational structure.

Consolidation and extension training for all employees, annual training for all employees, outsourced training, academic education support

To organize the overall competitiveness and provide solid talent support for the company's steady development.

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Training progress during the reporting period Employee development

During the reporting period, the company organized and carried out multi-level and multi-form employee training activities: The company respects employees’ career development pursuits, establishes a fair and transparent employee development and promotion mechanism, and provides employees with diversified development paths and clear growth space.

Internal training, external and joint training. After becoming a manager, you can be promoted to:

Project management, personnel management quality control, training,

Professional CRC, management

SCRC I

█ Conducted 24 internal “micro classroom” live training sessions; █ Organized or participated in 61 external training sessions, including 28 online sessions and CRC II

█ Implemented a training plan for all employees, forming 23 training items throughout the year, with 33 training sessions, with a total training time of approximately 65.6 hours. CRC I 05 covers system updates, compliance requirements and professional skills, etc. 03

Case: Systematic promotion of employee training in 2025

Multi-channel development and promotion mechanism, performance evaluation and continuous communication, internal mobility and talent selection

In 2025, the company will focus on the ESG "human capital development", "responsible operation" and "industry collaboration" orientation, based on the existing "basic + entry + project" training system. Mechanism, employees can develop based on their personal needs in a wheel-driven model. Continuous communication between managers and employees requires an application for internal transfer or location transfer; and job standards to ensure that employees at all levels have a clear understanding of the performance goals and position period. The performance evaluation standards are open and the procedures are fair for personnel in positions or regions. In the performance feedback, the company gives priority to the appointment and promotion opportunities of managers at all levels through internal open recruitment. Obtain growth suggestions and support, and promote employees to arrange qualified employees through recruitment methods.

Newcomer training Compliance training

The system is standardized and transparent. Continue to maintain a positive professional status. Support the diversified development of employees. Implement a 3-month standardized training path, and continue to carry out SOP/Policy update training and GCP,

Apprenticeships, weekly review and approval of work logs, etc., covering 48 core knowledge SAE/AE, information confidentiality and other special training to strengthen employee cooperation

knowledge points and 36 practical projects to consolidate employees’ basic job capabilities. Awareness of regulations and risk prevention capabilities.

Case “Elite Class” Targeted Training Program

In 2025, the company will launch a special training project of "Elite Class" around the construction of management talent echelon, and carry out systematic management for key employees in core business.

Project-specific training Institute-enterprise collaborative training

Cultivation of rational ability. Through a standardized selection mechanism, the project selects training candidates based on employee development potential and career aspirations, and proactively assists partner hospitals in planning and conducting joint training around role recognition, team management, project plans, EDC systems, randomization assistance, etc. The company

Courses are set up on cross-departmental collaboration and employee coaching, using a combination of online teaching and case studies to strengthen the integration of learning and practice. Carry out targeted training to improve employee project execution and dispatch senior lecturers to participate in teaching, combined with analysis of real project cases

Same ability. Compliance points and promote the joint construction of a compliance ecosystem in the clinical trial industry. During the reporting period, the company selected a total of 129 employees into the elite class. The training results have been gradually applied to team management and project execution, and their performance has been

Excellent personnel are included in the management talent reserve system to continuously provide management strength for the company's mid- to long-term development.

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Occupational Health and Safety

Purisi has always adhered to the "people-oriented" development concept and regarded employee occupational health and safety as an important part of the company's sustainable development. The company combines its own work-related accident management

Based on the business characteristics and employee work scenarios, we continue to improve the occupational health and safety management system, and systematically promote risk identification, health management, safety protection, education and training. █ In order to effectively prevent and control the occurrence of work-related injuries, standardize the emergency response and reporting management of work-related injuries, effectively protect the legitimate rights and interests of employees, conduct training and emergency management, and strive to create a safe, healthy and stable working environment for employees, and protect the physical and mental health and legitimate rights and interests of employees. Sri Lanka has established and continuously improved the work-related injury and accident management system, clarified the scope of work-related injury identification, reporting process and division of responsibilities, effectively reduced the risk of work-related injury accidents through institutionalized and process-based management, and continued to improve the level of occupational health and safety management.

█ The company regards work injury prevention as an important part of occupational health and safety management, and continues to promote safety publicity and education and training through diversified methods. In 2025, the company will release safety advocacy content and posters through all-employee emails and internal corporate communication platforms, and the heads of each department will

Occupational Health and Safety Risk Assessment

Conduct safety presentations in employee meetings to promote the implementation of safety regulations and risk prevention requirements in all business links. Through continuous safety education, the company has established and implemented an occupational health and safety management system covering all employees, clarified management objectives, division of responsibilities and implementation requirements, and passed

Through education and risk reminders, employees’ ability to identify potential safety risks and self-protection awareness during their daily work and commuting to and from get off work have been effectively improved with institutionalized management to prevent and control occupational-related risks.

As a result, safety behaviors have gradually been integrated into daily work practices, playing a positive role in the prevention of work-related injuries and further consolidating the company's occupational health. In daily management, the company conducts safety risk inspections in office areas from time to time, focusing on fire escapes, electricity safety, and office environment sanitation.

and safety management basics.

Monitor the health and equipment operation status, and promptly discover and rectify potential safety hazards. At the same time, the company pays close attention to extreme weather and social and public safety information.

During important periods or special circumstances, safety reminders are issued to employees in a timely manner to reduce the impact of external risks on employee safety.

█ In view of the fast pace and high pressure of work in the clinical trial industry, the company continues to pay attention to the mental health of employees and provides mental health support

and communication mechanisms to help employees relieve work stress and prevent mental health risks.

Safety training and emergency response

█ The company attaches great importance to employee safety awareness and emergency response capability building, and regards safety training and emergency management as important components of occupational health and safety management. During the reporting period, the company adhered to the principle of "safety first, prevention first, and comprehensive management", and continuously improved safety management levels through regular training, regular inspections, and emergency drills to create a safe and stable working environment for employees.

occupational health

█ In terms of occupational health protection, the company purchases supplementary medical insurance for eligible employees in accordance with laws and regulations, and organizes employees to undergo health check-ups every year.

Check-ups help employees keep track of their own health status and enhance their awareness of disease prevention and health management.

█ In view of the occupational characteristics of clinical trial site management and other positions, the company provides relevant employees with necessary occupational protective equipment, including white coats,

Management module Management measures Development status in 2025 Management results

Clothes, masks, gloves and disinfection supplies, etc., and special protection training will be carried out based on the actual situation of the job to strengthen employees' self-control during project execution.

We must improve our awareness of protection and effectively protect the occupational health and safety of our employees. Combining the characteristics of the office, we organized 2 fire emergency drills to improve employee fire safety awareness and emergency response. In terms of mental health, the company provides employees with a national psychological consultation hotline and online consultation service platform, and conducts fire safety training and emergency drills to cover all employees through mental health training and publicity; it also carries out office activities throughout the year to provide employees with convenient and effective psychological support channels to help employees maintain a good mental state. and carried out standardized inspection and maintenance of fire protection facilities 12 times. The fire safety risks of the institute were effectively controlled.

Fire training and emergency drills

Management and regular maintenance control

Focusing on fire escapes and electricity safety, we organized and carried out quarterly activities during the reporting period to continuously improve the safety level of the office environment.

Office environment and equipment operation status, safety and health inspections, problems found are escalated, and safety hazards are eliminated in a timely manner. Occupational safety Carry out regular safety and health inspections, and promptly rectify and review problems.

Quarterly safety and health inspections

█ The company has established and continuously improved the work-related injury and accident management system, clarified the scope of work-related injury identification, accident reporting process and division of responsibilities, standardized work-related injuries and implemented a closed loop of problem rectification.

Emergency response and reporting management of accidents ensure the legitimate rights and interests of employees in the event of work-related injuries.

█ In terms of office environment safety management, the company strictly implements fire safety management requirements to ensure that fire passages in the office area are smooth and fire protection facilities are equipped. Safety training is organized and carried out once through centralized training, publicity and reminders, and employee safety awareness and risk identification are fully equipped and regularly maintained. An emergency medicine box is set up in the office area, equipped with band-aids, thermometers, commonly used medicines and other medical supplies, in order to continuously strengthen employees' safety awareness. The training content covers fire safety and further enhances their capabilities, in order to prevent sudden physical discomfort or accidents that may occur during the office hours. Awareness and risk prevention capabilities, earthquake emergency response and flood prevention common sense, laying the foundation for all accidents

Safety education and training

Cover all employees

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Through continuous content output and compliance consulting support, some patients and their families established further communication with the research center and received professional assessment and follow-up support after fully understanding the relevant information about social contribution. This process adheres to the principle of clear boundaries between information guidance and decision-making, and does not replace doctors’ diagnosis and treatment opinions. It only lowers the threshold of understanding at the information level and helps patients make better informed choices.

The consultation and interactive feedback received by the platform throughout the year reflects patients' need for standardized and objective health information. Based on its own business characteristics and social responsibility positioning, Puriris continues to pay attention to social issues such as medical accessibility, educational support and rural development, and combines public welfare actions with professional

The real demand for information also provides an important reference for the company to continue to optimize the direction of science popularization content. Combining professional capabilities and resource advantages to promote the pragmatic implementation of public welfare projects. The company actively responds to the epidemic through various forms such as health science popularization, educational assistance, and consumption assistance to farmers.

Based on the actual needs of different groups, we will continue to expand the depth and breadth of public welfare actions under the premise of compliance, and strive to achieve coordinated advancement of corporate development and social value.

The long-term operation of "Rui's Home" will help alleviate the asymmetry in patients' disease awareness and access to medical information. It will also help the company improve the transparency of clinical trials and innovative treatment information under the premise of compliance, allowing the company to support public health education with professional capabilities and promote medical information.

medical accessibility

Sources can reach different groups of people more equitably and effectively.

Puruis is based on the field of pharmaceutical research and development and clinical trial services, focusing on patients' actual needs in disease awareness, medical information acquisition and medical decision-making. rely on

With its professional advantages in the fields of pharmaceutical R&D and clinical research services, Puruis continues to carry out health science popularization and patient support, and strives to lower the threshold for obtaining medical information.

rural revitalization

By building a patient health science popularization and consultation platform, the company carries out science popularization work related to disease prevention and treatment, standardized medication and innovative treatments, and strives to lower the threshold for obtaining medical information.

During the reporting period, the company actively responded to the national rural revitalization strategy and participated in regional development through education assistance and consumption assistance to farmers: improving public health literacy, alleviating patients' asymmetry in access to medical information, and helping medical resources reach different groups of people more equitably and effectively.

Case “Purisi Aids Xinjiang Bookstore”: A case that lights up the reading dreams of children in border areas Operates the “Rui’s Home” patient health science platform to improve the accessibility of medical information

With the support of relevant league organizations and local units, the company implemented the "Xinjiang Aid Bookstore" project in the No. 1 Primary School of Yixi Laimuqi Township, Wensu County, Aksu Prefecture, Xinjiang, donating books and reading equipment. In the context of the continuous acceleration of disease diagnosis and treatment and the development of innovative drugs, patients and their families have better access to disease awareness, treatment options and clinical trial-related information.

and learning materials, and completed the layout and unveiling of the reading room based on the actual campus conditions. In terms of donated bibliographic references, we still face practical problems such as scattered information, high threshold for understanding, and insufficient professional interpretation. As a provider of clinical research services, Puruis is committed to

Examination of the catalog recommended by the education department, and a total of 933 books have been donated, covering literary classics and suitable books. On the premise of not replacing medical diagnosis or intervening in medical decision-making, we continue to explore ways to improve the transparency of medical information through health science popularization and compliance consultation.

Age-appropriate reading materials provide students with diverse reading choices and complete the layout of the reading space to ensure accessibility and accessibility.

Create a better reading environment for local students.

During the reporting period, the company continued to operate the patient health science popularization platform “Ruizhijia” and carried out systematic health science around common diseases and key treatment areas.

General work:

Case: The "Puris Scholarship" was established to help students from border areas pursue their dreams. A total of more than 600 health science content articles were published throughout the year, covering tumors, metabolic diseases, bone and joint diseases, and the nervous system.

In terms of content construction, in various fields such as diseases, the content focuses on basic knowledge of diseases, standardized diagnosis and treatment concepts and key health management points. Through Duoping, it focuses on educational assistance and talent training. Puruis established the "Purisi Prize Platform Communication to expand the scope of reach. Bursaries" at the Central School of Fuyan Town, Menglian County, Yunnan Province, and carried out targeted student aid through multi-party collaboration.

The company donated special funds, which were coordinated and managed by the local youth league organization. During the reporting period, the company donated 40,000 yuan in targeted funds and responded to the health consultation needs of nearly 1,000 patients and their families through online consultation and public welfare Q&A.

In terms of consultation and interaction, it is used to support students from families with financial difficulties to complete their studies. The relevant funds are directly distributed to student guardians through standardized procedures to help them understand disease-related information and medical treatment paths.

personal account to ensure transparent and accurate use.

This project provides practical support for students with excellent academic performance and financial difficulties, and enhances students' confidence in continuing their studies. Without providing medical diagnosis and treatment suggestions, it carries out science popularization related to clinical trials and introduces the basics of clinical trials.

Compliance science popularization

It has also injected positive force into promoting the development of local education.

Concepts, participation procedures and precautions to help patients and their families in need understand innovative treatments and clinical trial information.

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Case: Charity and assistance to farmers: promoting the development of rural industries and enterprises "two-way" diversified and inclusive cooperation management mechanism

█ During the reporting period, the company continued to improve the supply chain diversification and inclusive cooperation management system, and systematically incorporated the cooperation requirements with small and medium-sized enterprises and diversified business partners into procurement policies and ESG management objectives. The company has established a diversified business partner database and proactively included them in bidding, inquiry and other processes.

Qualified small and medium-sized enterprises will participate in the selection, and if the quality, service and comprehensive cost conditions are equivalent, priority will be given to cooperation with them. At the same time, in order to actively respond to the national rural revitalization strategy, Puruis regards consumption assistance as an important way to participate in rural revitalization.

The company has clarified the division of responsibilities of procurement, sustainable development and other relevant departments, and promoted the effective implementation of diversified cooperation requirements at the business execution level.

In 2025, the company will build a specialty agricultural product procurement network covering 7 key agricultural counties (regions) including Yuxi, Shufu, Menglian, etc., and have completed a total of 7

Targeted purchases are made in batches and relevant products are distributed as employee benefits. At the same time, the company actively assists in connecting with external resources and promotes the import of some agricultural products.

Support the common development of small and medium-sized enterprises

Enter a broader market and achieve industrial empowerment.

█ On the basis of institutional guarantees, the company actively promotes practical cooperation with small and medium-sized enterprises and diversified business partners. In 2025, the company's public welfare actions to assist farmers in the logistics services and other industries have effectively broadened the sales channels of agricultural products, promoted farmers' income increase, and also enhanced employees' sense of participation and identification in rural revitalization. In the business field, the company continued to cooperate with a number of small and medium-sized enterprises. In terms of contract signing, contract performance and settlement arrangements, it followed the principles of fairness and reasonableness to avoid achieving a win-win synergy between corporate development and social value. Set unnecessary barriers to cooperation and support small and medium-sized enterprises to stably participate in company business activities. Through long-term cooperation and collaborative development, the company is ensuring its own business

While operating stably, it also provides small and medium-sized enterprises with cooperation opportunities for continued growth and capability improvement.

Continuous improvement and future commitment

█ Looking forward to the future, Puruis will continue to deepen the work related to equal treatment of small and medium-sized enterprises, gradually expand the coverage of the diversified business partner database, explore more flexible and diverse cooperation models, and continue to disclose relevant management measures and progress in the ESG report to promote continuous improvement through transparent management.

Work with partners to build a fair, inclusive and sustainable value chain system.

Promote industry cooperation

Puruis actively participates in the collaborative development of the industry and promotes the standardization and capability improvement of the clinical research service industry through industry-university-research cooperation, industry initiatives and professional exchanges.

School-enterprise cooperation/industry-university-research cooperation

█ Puruis actively leverages its professional advantages in the field of clinical research services and continues to promote the coordinated development of industry, academia and research. By carrying out industry-education integration cooperation with colleges and universities, it helps talent training and capacity building in the pharmaceutical industry, promotes the organic connection between the education chain, talent chain and industrial chain, and provides sustainable talent support for the high-quality development of the industry. During the reporting period, the company continued to deepen cooperation with Anhui Anqing Medical College and jointly promoted drug clinical research and monitoring.

Manage the construction of undergraduate micro-majors and further improve the talent training system in the field of clinical research.

Industry Cooperation/Participation

Treat small and medium-sized enterprises equally

█ In 2025, as a corporate representative, the company participated in and supported the Shandong Province CRC industry ecological co-promotion initiative and actively responded to the industry's self-discipline and standardized development requirements. Puruis will treat small and medium-sized enterprises equally as an important part of fulfilling social responsibilities and promoting the sustainable development of the value chain, actively promoting the diversification and inclusiveness of the supply chain, and promoting the professional construction of the CRC team and the improvement of industry capabilities. At the same time, the company continues to participate in pharmaceutical and clinical research-related industry associations, societies and professional cooperation. In the procurement and cooperation process, the company adheres to the principles of openness, fairness and impartiality. On the premise of ensuring quality and compliance requirements, it provides equal participation opportunities for small and medium-sized enterprises and women's organizations, focusing on issues such as clinical research coordinator (CRC) management standards and professional capacity building, participating in local industry norms and group standards and minority group-operated enterprises, helping to build a more open, inclusive and resilient industrial ecology. quasi-related seminars, and provide support for industry capacity building and normative development through industry training, experience sharing and professional exchanges. through the above

To participate, the company actively integrates into the collaborative development process of the industry and promotes experience sharing, standard consensus and ecological co-construction in the field of clinical research services.

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external communication external communication

"Industrial Lecture Hall" "The Development Story of Private Enterprises in Huangpu in the New Era" column program recording 2025 Puris Clinical Trial On-site Verification Experience Sharing Session·Beijing Special

Activity theme

Focusing on the docking of clinical trial verification compliance with international standards, focusing on regulatory policies and sharing the company's practical experience and value in the field of clinical research services

Implementation of policies, verification of risk prevention and control, and construction of multi-party collaboration mechanisms. Through political concepts, Purixis demonstrates its role in promoting pharmaceutical research and development innovation and fulfilling social responsibilities.

policy interpretation, risk case analysis and practical experience sharing, and explore and achieve results in building the sponsor, appointing and integrating into the regional business environment construction. Activities

Professional communication platform between clinical trial institutions and SMOs. As an important platform for regional private economic exchanges, the event promotes the sharing of enterprise experience.

Standardize domestic and foreign regulatory requirements, explore verification key points and response paths, promote the spread of social value, and help high-quality development of regional industries.

The improvement of clinical trial compliance capabilities will help the standardization, professionalization and international development of the industry.

"Into Comprehensive Internal Medicine" Hospital-Enterprise Closed-door Exchange Meeting

The "New Quality Productivity Research Trip" initiated by Shanghai News Broadcasting Station of Shanghai People's Broadcasting Station enters the theme of Puruis activity

Activity theme

Focusing on the integration and collaborative innovation of clinical research resources in the field of oncology, we build a medical

It is an in-depth exchange platform for hospitals, pharmaceutical companies and clinical research service institutions, focusing on the "Key Issues such as Improvement of New Quality Productivity Clinical Trial Efficiency, Compliance Management and Patient Recruitment, Research" launched by the Shanghai News Broadcasting Station of Shanghai People's Broadcasting Station. Entering Puriex, Chen Xia, Vice President of Puriex, accepted an exclusive interview with the host to promote multi-party collaboration to solve practical problems in new drug research and development, promote pharmaceutical research and development, and introduce the development history and corporate culture of Puriex, as well as the standardization and high-quality development from the system. Researchers from industry and finance fields jointly discuss the development of innovative drugs.

"Proving Ground + Accelerator"

Reconstructing the Pharmaceutical Innovation Ecosystem and Launching Ceremony of the 2025 Shanghai Institute of Pulmonary Science Enterprise Exchange Series Events

Activity theme

Focusing on clinical research and innovative drug research and development in the field of pulmonology, it combines specialized

Hospitals, pharmaceutical companies and professional service organizations jointly explore the clinical trial process

Optimize and innovate ecological co-construction paths. The activity is organized through the establishment of professional vertical leadership

The exchange mechanism between institutions and enterprises in the field promotes the improvement of clinical research capabilities and medical innovation.

Efficient allocation of new resources helps the sustainable development of the medical innovation ecosystem.

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Green and environmentally friendly

Helping the country’s low-carbon development

Addressing climate change 80

Environmental Compliance Management 84

Efficient use of energy 86

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strategy

Tackling climate change

Puruis is deeply aware of the potential impact of climate change on the company's business, especially the complex systemic relationship between risks and opportunities related to climate change, including policy changes caused by climate change, the pressure brought by extreme weather on production operations, and the resulting opportunities for technological innovation and green transformation. We not only consider external factors, such as policies and regulations that affect the company's operations, historical data and future forecasts of extreme weather events, but also internal factors such as the company's operating characteristics and business growth model.

Puruis actively practices the concept of sustainable development, organically integrates climate change-related functions into the ESG governance structure, and establishes and gradually improves the climate change governance system.

Based on the analysis of risks and opportunities related to climate change, combined with the company's operating model and carbon emission reduction practices, Puruis has formulated a three-level strategic direction in response to climate change:

Climate change governance subject roles and responsibilities

█ Review and confirm climate change response systems and mechanisms, and review climate change risk management and internal control systems Operational management level

effectiveness of the system

decision making

█ Review ESG strategies and plans including climate change, annual key performance indicators and target achievement, energy management and energy conservation and emission reduction, resource recycling

The Board of Directors, including reviewing greenhouse gas emission reduction targets and paths, and approving budgets related to addressing climate change █ Prioritize the use of energy-saving equipment and electrical appliances in offices, such as LED lights, █ Establish a complete garbage classification and recycling system, and classify paper, plastic, metal

Energy-saving air conditioning, etc., optimize the use time and temperature of lighting and air conditioning systems, classify and collect and process recyclables such as metals, and improve the recovery of resources. Review, evaluate and supervise major issues in response to climate change. Revenue utilization rate.

Supervise █ Research and guide the design of strategies, goals and tactics on issues related to climate change █ Promote digital office methods such as telecommuting and video conferencing to reduce █ Encourage employees to bring their own water cups and other utensils to reduce the use of disposable paper cups, █ Report to the board of directors on progress in addressing climate change Transportation carbon emissions generated by employees due to business trips, commuting, etc. Reduce the consumption of disposable office supplies.

Strategy and Sustainability Committee

█ Assess and manage risks and opportunities related to climate change

Clinical trial project execution level

ESG █ Guide and develop climate-related vision, goals, strategies and roadmaps

management

█ Track and supervise key risk indicators and carbon emission reduction target progress Green clinical trial design Transportation and logistics optimization

ESG Management Committee █ Communicate with relevant stakeholders on climate change issues, and carry out publicity and capacity building activities █ Fully consider climate change during the design stage of clinical trial plans █ Choose environmentally friendly transportation methods, such as rail, for the transportation of trial materials

The potential impact of factors on the test results, such as the impact of extreme weather on road and water transportation, etc., is prioritized over road transportation to reduce carbon emissions. █ Identify climate change risks and opportunities, recruitment, compliance implications, etc. █ Properly plan material distribution routes and times to reduce transportation mileage and empty execution █ Resource coordination and guarantee for climate-related strategy implementation and risk management █ Optimize the test process, reduce unnecessary links and waste of resources, reduce transportation mileage, and improve transportation efficiency.

█ Track the implementation and achievement of climate-related goals, such as using electronic medical records, electronic informed consent, etc., to reduce █ For multi-center clinical trials, try to choose sites closer to the ESG working group

Paper usage. Use nearby warehouses as material storage points to reduce transportation distances.

█ Implement carbon emission reduction targets based on department functions at the operational level

Execution █ Carry out internal capacity building activities on climate change Supply chain management level

█ Provide insights and suggestions for processes such as identification of climate risks and opportunities and formulation of climate-related strategies

Functional departments responsible for relevant issues

Supplier screening and cooperation Supply chain information management

█ Prioritize suppliers with good environmental performance and sustainable development concepts █ Promote suppliers to continuously improve their environmental performance through information sharing and collaborative cooperation

Suppliers should clarify environmental protection requirements in procurement contracts, encourage suppliers to improve their environmental performance, and jointly respond to climate change.

During the reporting period, the company continued to strengthen the supervision and decision-making responsibilities of the board of directors and relevant special committees in climate change governance, and regularly reviewed climate-related issues.

Use clean energy, energy-saving emission reduction measures and environmentally friendly packaging materials.

progress, key indicators and management measures, incorporate climate change into the company's mid- to long-term strategies and annual business management discussion framework, and promote climate governance from system establishment to

Continuously run transformations. █ Carry out energy conservation and emission reduction projects with suppliers, such as optimizing raw material procurement

procurement, production process improvements, etc., to reduce carbon emissions across the entire supply chain.

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Risk and Opportunity Management Goals and Indicators

We regularly assess climate change risks and opportunities, and strive to reduce the identified major climate change risks through active collaboration with internal and external parties. Based on the principles of scientificity and executability, Puruis gradually builds a climate change goal and indicator system that matches the company's business characteristics and development stage. The company's impact since its establishment, and seize the opportunities as much as possible to promote the company's sustainable development and value chain improvement. 2024 will be used as the base year for greenhouse gas emission accounting, and 2025 will be determined as the starting stage for the formal implementation of climate goals and improvement of the management system, focusing on

Focus on establishing goals, aligning paths and building management mechanisms.

We continue to track, evaluate and update the list of climate change risks and opportunities based on changes in the company's internal and external environment and our own business plans, and constantly improve the climate change risk and opportunity list.

climate risk and opportunity management. During the reporting period, on the basis of fulfilling its commitment to the Science-Based Target Initiative (SBTi), the company set recent greenhouse gas emission reduction targets that have successfully passed the verification of SBTi.

At the same time, the company has completed the accounting of greenhouse gas emissions with 2024 as the base year, and has incorporated scope 1 and 2 emissions into the scientific carbon target management framework. During the reporting period, the company used the climate risk prioritization analysis completed in 2024 as the management baseline. During the reporting period, the company further incorporated relevant risks into normalized management and promoted relevant management work in stages for scope 3 emissions in accordance with the principle of "first identification, then quantification, and then management". Management and continuous monitoring mechanisms are in place to maintain focus on high-priority risks and timely update risk judgments based on changes in the internal and external environments.

In addition, the company participated in the CDP climate change questionnaire disclosure and received a B-level (management level) rating in 2025. The company has made phased progress in climate governance and information disclosure. Risk type No. Risk description Probability of occurrence Impact degree Vulnerability Urgency.

1 Climate change information disclosure requirements are becoming stricter High Medium Extremely Low Low 1 Table: Greenhouse gas emissions at the operational level of Puruis

2 Strengthen supervision of the environmental impact of products throughout their life cycle High Low Low Low

Indicator Unit 2025

3 Full transition to renewable energy High Medium Low Low

Imposing carbon taxes on high-emitting products and stipulating corporate carbon emissions Scope 1 (direct) greenhouse gas emissions tons of carbon dioxide equivalent 20.45 4 Medium Low Very Low Low

Transformation Quotas, etc.

risk

5 Technological upgrading or innovation for low-carbon economic transformation High Medium Low Medium

Scope 2 (indirect) greenhouse gas emissions tons of carbon dioxide equivalent 313.49Customers and consumers tend to use environmentally friendly products

6 High High Higher Medium

and services

Suppliers may be affected by carbon reduction policies, resulting in increased operating costs

7 High Medium Low Low

Add, raise product selling price

Stakeholders’ opinions on corporate actions to address climate change and

8 Low Medium Very Low Low 1 The company conducts greenhouse gas emission accounting in accordance with the GHG Protocol, and organizational boundaries use the operational control method to determine progress.

2 Scope 1: Direct greenhouse gas emissions generated by emission sources owned or controlled by Puruis. Upstream and downstream partners fail to effectively respond to climate change

9 Medium Medium High Medium 3Scope 2: Indirect greenhouse gas emissions generated by Puruis’ energy purchase.

negative consequences

Climate change may cause environmental emergencies. If companies do not

10 Very low Very low Low Very low

Effective response to negative impacts

11 Frequent occurrence and increasing severity of extreme weather such as typhoons and heavy rains High Low Low Low

Entity

12 Abnormal temperature changes lead to high temperature drought or low temperature cold wave. Medium Medium Extremely Low Low

risk

13 Sea level rise low very low very low very low

14 Water stress Medium Medium Medium Medium

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On this basis, a water-saving supervision mechanism was established:

Environmental Compliance Management

Establish a water-saving team composed of representatives from various departments to oversee the implementation of water-saving measures and collect feedback.

Set up a water conservation group

Continue to optimize water-saving plans.

environmental management policy

Puruis has incorporated environmental protection into the company's sustainable development management system, formulated and implemented the "Environmental Management Policy", and clarified the company's environmental protection and resource conservation aspects.

Regular water-saving inspections The water-saving team will conduct regular water-saving inspections in various departments, and report and correct behaviors that waste water resources. responsibilities and commitments. The company insists on integrating business development with environmental protection. On the basis of complying with national and local environmental protection laws and regulations, it continues to reduce

The impact of operating activities on the environment promotes the coordinated development of corporate operating activities and the ecological environment.

The company will commend and reward departments and individuals with outstanding performance in water conservation work to encourage everyone to take active environmental management measures. Water conservation reward mechanism

Participate in water conservation initiatives.

Strengthen environmental education, water resources management, waste management

Puruis takes environmental education for employees as a measure to promote environmental management. Puruis integrates water resources management into the environmental management system. Puruis integrates waste management into the environmental management system. Combined with the business characteristics of office operations and clinical research services, Puruis continues to promote the management path of "source reduction - classified distribution - effective implementation. Through systematic publicity and office operation characteristics, it continues to promote water-saving management and water use regulations. Compliance recycling/disposal" management path. The company reduces waste generation from the source by advocating paperless office and reducing the use of disposable office supplies; it also provides training to enhance employees' awareness and participation in environmental issues. Through system publicity, internal publicity and daily management, the company introduces and configures classification and distribution facilities in the office. It also enhances employees' classification awareness through environmental training and publicity, and promotes the implementation of waste management requirements in daily operations. During the reporting period, the company focused on the basic concepts of ESG, greenhouse gas

Guide employees to establish water-saving awareness and use water in office and daily life

emissions, waste management, biodiversity protection and other topics. In terms of classification and disposal, the company focuses on standardizing the classification and recycling of recyclables such as paper, plastics, metals, and glass; waste batteries, waste electronic equipment

Practice the concept of water conservation and strive to improve water resource utilization efficiency,

Carry out environmental protection special training and publicity education for employees, collect equipment and other items that may contain harmful ingredients separately and hand them over to qualified recycling and disposal channels to reduce environmental risks. The company continues to optimize waste

Reduce the impact of operational activities on water resources and the environment.

Guide employees to understand the company's environmental policies and their own waste management processes in daily work, and ensure that classification, temporary storage, transfer and other links are traceable and inspectable.

In specific management practices, the company has adopted a number of water-saving measures,

and responsibilities in life. By combining energy-saving office and green export

Including advocating the use of reusable water bottles and reducing disposable

Specific scenarios such as transportation, waste classification and resource recycling, company type, main source, main processing method

When using the product, check water facilities regularly to prevent leaks and leaks.

The company promotes the integration of environmental protection concepts into employees’ daily behaviors and gradually forms

And set up water-saving reminder signs in public areas. At the same time, the company's recyclable materials such as paper, plastic bottles, metal, and glass are put away in categories, and centralized recycling creates a good environmental protection atmosphere where all employees participate and practice together to contribute to the environment.

The realization of management goals provides a continuous basis of manpower and awareness. Strictly abide by national and local laws and regulations on sewage and wastewater management. Hazardous waste, waste batteries, and waste electronic equipment/accessories are collected separately and recycled and disposed of in compliance with regulations. During the reporting period, the company implemented environmental training for all employees. Domestic sewage generated during operations was collected according to the regulations of the office where it is located.

100% coverage. It is handled in a unified and standardized manner and does not involve the discharge of highly polluting industrial wastewater. Other garbage, research waste (indirectly related), and biological sample waste are placed in other designated trash cans, and are processed by professional institutions to ensure that sewage and wastewater are disposed of in accordance with laws and regulations.

Kitchen waste, meal leftovers, etc. are sorted and transported according to property or territorial requirements.

biodiversity

Daily office production links Domestic water management

Combining the company's business characteristics with office operations and clinical research services as its main focus, Puruis pays close attention to ecosystems and biodiversity. █ Use water cups instead of disposable paper cups, █ Regularly check water dispenser equipment to prevent █ Set water-saving signs in public areas to remind employees.

The direct impact of sex is relatively limited. The company still incorporates the concept of biodiversity into environmental management and employee awareness-raising efforts to reduce water waste. Running, popping, dripping and leaking phenomena. Save water.

█ Encourage the recycling of production water, such as █ Encourage employees to use water-saving sanitary facilities, such as water-saving sanitary ware

High-risk activities that cause significant ecological impact, and pay attention to the partners' seals in supply chain communication and green procurement advocacy to save water resources. Cooling water, cleaning water, etc. Toilets, water-saving faucets, etc.

Environmental Compliance Performance. During the reporting period, the company made biodiversity one of the important topics in environmental training.

Promote and enhance employees’ basic understanding of relevant issues and daily behavioral awareness.

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Energy Efficient Utilization Action Areas Management Initiatives 2025 Practice Points ESG Value

About 80% of the lighting in the Shanghai headquarters was replaced with LED; the central air

Green office optimizes office energy, reduces operational energy consumption, implements intelligent frequency conversion transformation and sets energy-saving temperature control standards;

Efficiency and environmental quality Improve the working environment of employees. Combining its business characteristics as a knowledge-intensive service enterprise, Puruis will use digitalization and technology to build green buildings in terms of office equipment and IT resource management.

Office building is LEED certified

As an important means to reduce the impact of operating environment and improve resource usage efficiency, green office improves energy usage efficiency and continues to promote server virtualization and system optimization.

We must start by continuing to promote officeization that combines digitization, low-carbonization and standardization, and reduce the number of physical equipment and operating energy consumption. At the same time, the company’s electronic equipment

management mode. During the reporting period, the company focused on energy conservation, consumption reduction and efficient resource utilization. In equipment management, the company paid attention to the environmental impact of the entire life cycle and implemented regulations on office equipment.

Promote energy conservation, deepen paperless office, and fully use the ERP system; implement

In terms of standardized management of electronic equipment, we systematically carry out green office practices and promote configuration, update and recycling management. For those that have reached their service life or are no longer available, reduce resource consumption and train

Water conservation and efficient use of resources implement the "power outage" system; set up classified recycling facilities and

Implement green concepts in daily operations. Using valuable computers and related electronic equipment, the company cultivates a green office culture in accordance with internal asset management.

green office

Use compliance disposal

Carry out unified recycling and disposal through the process, giving priority to trade-in or compliance recycling

In terms of office operation and management, the company continues to deepen paperless office and submits it to qualified third-party agencies for processing through all channels to prevent the impact of electronic waste on

We use ERP and other information systems comprehensively to cover project establishment, process approval, and improper impact on the environment, and promote the reuse and standardized disposal of resources.

Document management and daily collaboration, etc., effectively reduce the use of paper and related consumables. Prioritize the purchase of new energy vehicles and install charging piles; provide public

Encourage low-carbon commuting and reduce employee commuting and use. At the same time, the company implements energy-saving and electricity management requirements and promotes green office initiatives in the office. By continuing to promote green office initiatives, the company is reducing resource consumption and the environment. Public transportation subsidies; encouraging high-speed rail to replace short-distance flights and promoting

Travel patterns Travel-related emissions

Green travel

We have promoted energy usage regulations such as “power outage when people are away”, combined with the use and risks of energy-saving lighting equipment, further cultivate employees’ awareness of green office, and promoted green and online meetings.

Reasonable air-conditioning temperature control settings guide employees to develop energy-saving behaviors in daily work. Low-carbon and standardized working methods have gradually become the normal state of organizational operation, which provides a good foundation for the company.

Make it a habit to reduce office energy consumption. Provide stable support for the realization of environmental management goals.

Optimize documents and promote centralized distribution and non-emergency "next-day delivery" models to reduce carbon and green travel in logistics. Material distribution methods reduce transportation frequency and emissions.

Green transportation and logistics

Puruis pays attention to the energy consumption and carbon emissions of employees during commuting and business travel. In travel management, the company encourages the use of video conferencing, online communication and other alternative methods.

Open up and regard green travel as an important extension of efficient energy use. The company will conduct non-essential offline business trips, and when travel is truly necessary, priority will be given to high-speed rail and other related travel options.

By improving supporting support and management guidance, employees are encouraged to choose more low-carbon and low-carbon transportation methods, reduce the use of short-distance flights, and reduce travel-related energy consumption.

Implement server virtualization to reduce the number of physical servers; improve IT energy efficiency and support environmentally friendly travel methods. Source consumption and emissions. Through digitalization and

Migrate some systems to a cloud platform that uses renewable energy; adhere to low-carbon digital transformation to reduce energy consumption

IT carbon reduction

Promote the trade-in and recycling of electronic equipment. During the reporting period, the company advocated giving priority to public transportation for employees’ daily commuting. Through the above measures, the company continued to guide employees to practice this in commuting and traveling.

We will provide public transportation subsidies and improve related green travel concepts to integrate low-carbon awareness into daily work behaviors.

Supporting conditions and other methods will create convenient conditions for employees to commute greenly. in business

86 87 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Indicator Unit 2025 2024 2023 ESG Key Performance

Operating income RMB 10,000 84,250.44 80,372.89 76,004.26

Net profit attributable to shareholders of listed companies Ten thousand yuan 10,963.81 10,642.93 13,472.98 Operations

performance

Total cash dividends (tax included) RMB 10,000 1,169.27 2,207.88 1,074.41Corporate governance performance

Cash dividend per 10 shares RMB 1.48 3.16 1.76

Indicator Unit 2025 2024 2023

Internal audit/risk assessment on business ethics issues

% 100 100 100 Number of shareholders’ meetings held 4 3 3 Percentage of operating sites

Business ethics training hours per capita Hours 2.1 1.8 2.2 Number of board meetings held 6 5 6

Business ethics training coverage (all employees) % 100 100 100 Number of board members Person 9 9 9

Average hours of senior management training on business ethics Hours 2.1 1.8 1.5 Male directors Person 8 8 8

Disclosure by gender

Business ethics training coverage (senior managers) % 100 100 100Female directors Person 1 1 1

Number of anti-corruption reporting incidents 0 0 0 Independent directors 3 3 3

Disclosure by type Number of confirmed corruption incidents 0 0 0Non-independent directors 6 6 6

Number of information security risk assessments carried out 8 6 3 Remuneration policy Average salary of directors Ten thousand yuan 39.25 34.72 35.15

Number of information security incidents 0 0 0 Company

business

Governance Strategy and Sustainable Development Committee meetings 1 1 1

Ethics Operation of an information security management system with ISO 27000 certification

% 100 100 100% of camp site

Number of audit committee meetings 6 4 5

Information security awareness training employee coverage ratio % 100 100 100

Number of Nomination Committee meetings 1 0 2 Information security risk assessment covers all workplaces/departments

% 100 100 100%

Number of meetings of the Remuneration and Appraisal Committee 2 3 4 Information security internal audit covers all workplaces/departments

% 100 100 100Percent

Percentage of executives hired from local communities % 89.57 66.67 68.75

Percentage of trading partners that have conducted information security due diligence % 100 100 100

Number of investor surveys received 135 105 131

Total number of complaints and reports on business ethics issues 0 0 0

Number of performance briefing meetings 1 1 1 — Number of reports from employees on business ethics issues 0 0 0

Number of responses to Huayi questions 64 73 37 —Number of reports from suppliers and contractors on business ethics issues 0 0 0

Interactive response rate % 100 100 100 — Number of reports from customers regarding business ethics issues 0 0 0

88 89

Employee Responsibility Performance

Indicator Unit 2025 2024 2023 Indicator Unit 2025 2024 2023

Total number of employees receiving training Person 4,372 4,416 4,186 Proportion of labor contract signing % 100 100 100

Total training hours hours 494,910.4 495,916.80 431,995.20Employee satisfaction % 95.70 93.20 100

employees

Rights and interests Percentage of employees receiving training to total employees % 100 100 100 Number of paid annual leave days per person Days 7 6 6

% of employees who have received regular performance and career development reviews

Gender pay gap ratio % 5.79 4.45 2.46 % 100 100 100% of employees

Employees who have received vocational or skill-related training as a percentage of total employees

Total number of employees 4,372 4,416 4,186 % 100 100 100

Percentage

Total number of male employees 337 316 279 Number of internal recruitment cases 105 165 110 Proportion of male employees among all employees % 7.71 7.15 6.67 Average length of training for employees Hours 113.20 112.30 103.20

employees

by gender

training

Total number of female employees Person 4,035 4,100 3,907 Average learning time for new employees Hours 279 279 279 Proportion of female employees among all employees % 92.29 92.85 93.33 Average length of time employees receive ESG training Hours 12 12 12 Age 51 and above Person 5 5 4 Total number of hours male employees receive training Hours 38,148.40 35,486.80 28,792.80

by gender

41 to 50 years old Person 60 55 38 Total hours of training for female employees Hours 456,762.00 460,430.00 403,202.40 By age

People aged 31 to 40 1,341 1,476 1,178 Total hours of training received by grassroots employees Hours 464,980.40 467,878.80 395,978.40

By employee Total hours of training received by middle management employees

Persons aged 30 and below 2,966 2,880 2,966 hours 29,360.00 27,888.00 34,468.80

Type Hours

Bachelor degree or above 3,108 3,075 2,827 Total number of senior management employees receiving training

Hours 570 150 1,548

hours

By educational background: College 1,247 1,324 1,342

Employees Social insurance coverage % 100 100 100Employment

Technical secondary school and below people 17 17 17

Number of work-related injuries Person 6 7 6 Proportion of female employees in middle management % 95.37 96.29 96.74

Number of work-related injuries 6 7 6 Proportion of female employees in senior management % 68.42 72.22 75.00 Employee health

Number of work-related fatal accidents Person 0 0 0

and safety

Number of ethnic minority employees 267 243 211

Number of working days lost due to work-related injuries Days 740 201 266 Proportion of ethnic minority employees among all employees % 6.11 5.50 5.04

Investment in safety production RMB 10,000 430.70 233.72 187.54 Number of disabled employees employed Person 27 22 13

Proportion of sites that have conducted employee health and safety risk assessment % 100 100 100Diversity

Proportion of disabled employees among all employees % 0.62 0.50 0.31

% covered by formal collective agreements % 100 100 100Number of employees from ethnic minorities in senior management People 1 1 1 Employees who have received diversity, anti-discrimination and/or anti-harassment training

% 100 100 100

Labor and Coverage

Representation of ethnic minority employees in senior management

Proportion % 5.26 5.56 7.14 Human Rights Review Proportion of sites that have undergone human rights review or human rights impact assessment % 100 100 100

coverage range

Number of employees with disabilities in senior management Person 0 0 0 Number of occurrences of child labor times 0 0 0 Proportion of employees with disabilities in senior management % 0 0 0 Number of annual internal audits for child labor or forced labor times 12 12 12

90 91 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

social responsibility performance

Definition of term

Indicator Unit 2025 2024 2023

Total number of suppliers 390 322 309

Proportion of procurement from local suppliers % 22 24 21 Noun Definition

Proportion of spending on purchases from local suppliers % 50 45 16

Company Law "Company Law of the People's Republic of China"

Percent signed Supplier Code of Conduct % 100 100 89.40

supply chain

Percentage of suppliers with signed environmental and labor clauses % 100 100 89.40

Management Securities Law "Securities Law of the People's Republic of China"

Percentage of suppliers that have conducted social responsibility questionnaires % 29 38.26 34.81

Total number of purchasing personnel 6 6 5

Shenzhen Stock Exchange Shenzhen Stock Exchange

Number of procurement staff receiving sustainable procurement training Person 6 6 5

Proportion of procurement personnel receiving sustainable procurement training % 100 100 100 Environment, social and corporate governance is also called ESG (Environment, Social and Governance). From the perspective of environment, social and corporate ESG

The three dimensions of governance evaluate the sustainability of corporate operations and their impact on social values. Number of participants in employee volunteer activities Person-time 1,573 1,571 1,545

society

Average employee volunteer time hours 4.8 4.8 4.8 SMO Abbreviation for clinical trial site management organization (Site Management Organization) Public Welfare

Rural revitalization fund investment RMB 10,000 42.48 13.9 30

The abbreviation of Contract Research Organization is a CRO for pharmaceutical companies and R&D institutions through contracts.

An academic or commercial scientific institution that provides professional services in the drug research and development process

Environmental Performance Functional Service Provider (FSP). Puris FSP business provides FSP for the sponsor

Provide the required professional human resources to solve problems such as urgent projects but no one in charge, and the inability to find experienced and suitable CRAs. Indicator Unit 2025 2024 2023 The full name is Site Start-Up, which is the preliminary preparation stage for clinical trials. Need to complete including research center selection survey, center project SSU

Environmental protection investment RMB 10,000 588.49 783.21 445.13 Preparatory work such as ethics approval, agreement preparation, review and signing, test site equipment setup, etc. Environment % of all workplaces that have adopted environmental risk assessment

% 100 100 100 CRC Abbreviation for Clinical Research Coordinator

% of management

Proportion of employees who have received training on environmental topics % 100 100 100

The abbreviation of "Good Clinical Practice" (Good Clinical Practice), issued by the National Drug Administration GCP of the People's Republic of China

Gasoline Kilogram 8,209.50 6,319.68 8,650.59 Formulated and implemented by the Supervisory Administration

Purchased electricity kWh 181,982.83 215,113.15 235,248.86

ICH Abbreviation for the International Council for Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use Energy Renewable energy production (photovoltaic power generation, etc.) kWh 0 0 0

Consumption Total energy consumption tons of standard coal 31.18 35.74 38.20

ICH-GCP GCP developed by ICH

Total renewable energy consumption kWh 0 0 0

Renewable energy as a percentage of total energy consumption % 0 0 0 Enterprise Resource Planning (ERP) system is an enterprise-level software solution that integrates various management functions and is designed to help organizations effectively manage and integrate their core business processes and resources. Puruis ERP system covers the total GHGs emissions tCO2e 333.94 342.90 432.89

Greenhouse gas ERP covers multiple fields, including financial management, contract management, project management, marketing management, human resources management, OA office processes, - direct GHGs emissions (Scope 1) tCO2e 20.45 21.33 20.91

Body emissions and BI analysis report functions provide enterprises with a unified data and process management platform. By using ERP systems, companies can manage their resources more efficiently, thereby increasing productivity and efficiency.

Municipal water purchase volume cubic meters 2,613 3,707 4,032

SOP abbreviation for Standard Operating Procedure

Water information Total water consumption cubic meters 2,613 3,707 4,032

Total wastewater discharge cubic meters 2,613 3,707 4,032

CRA Abbreviation for Clinical Research Associate

Total general waste generation

Ton 194.12 222.63 225.71

(Including total non-hazardous waste) National Medical Products Administration (NMPA) of the People’s Republic of China

Waste recycling volume tons 1.27 1.75 1.13 NMPA)

waste

Hazardous waste generation tons 0 0 0

FDA U.S. Food and Drug Administration (FDA) hazardous waste transfer volume tons 0 0 0

92 93 Puruis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puruis ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Indicator index

Continue to promote the digitalization and system research and development of clinical trials, independently research and develop technological innovation, create innovation and apply core technologies and platforms; improve service digitalization capabilities, competitiveness quality and industry efficiency through innovation capabilities to support pharmaceutical research and development innovation.

SDGs Index SDG 9 Industry, Innovation

and infrastructure

SDGs Goals Corresponding Issues Our Actions (2025) Report Chapters

Provide standardized and compliant clinical research services and strictly follow GCP

and medical ethics principles; build subject protection covering systems, processes and technologies; adhere to the principle of diversity, equality and inclusion (DEI) to ensure different genders, medical accessibility, diversity, inclusion, employee care and subject protection system; continue to operate the "Rui House" patient health, social contribution, equal employment and development opportunities for ethnic and disabled employees; through the establishment of patient and subject protection, equal opportunities, rights protection science platform, enhance public awareness and awareness of diseases and clinical trials, and communication mechanisms to safeguard employees' legitimate rights and interests.

SDG 3 Good health

SDG 10 Reduce inequality

Accessibility to medical information.

and well-being

Establish a training and development system covering the entire career cycle of employees.

Employee growth: Establish sustainable employee growth covering supplier access, evaluation and ongoing management. The average training time is 112 hours; promote the integration of industry and education and school-enterprise cooperation, sustainable procurement, and create a sustainable social contribution supply chain mechanism; promote industry capacity building of suppliers in compliance, environment and labor; participate in the construction of clinical research-related majors and micro-professionals, support industry responsible supply chain supply chain performance, and support small and medium-sized enterprises to participate in fair cooperation.

SDG 12 Responsible Consumption

Talent development.

SDG 4 Quality Education

and production

The proportion of female employees exceeds 90%, and a relatively high proportion of female managers;

Integrate climate change into the ESG governance framework; complete greenhouse gas emissions and adhere to the principle of non-discrimination in recruitment, promotion, salary and benefits; employee care and climate change response

Female employees’ rights and development. Open accounting, join SBTi, and participate in CDP climate disclosure; promote green environmental protection and support female employees’ career development and work rights protection through systems and caring measures. Low-carbon operations

Green office, energy conservation and emission reduction and low-carbon travel.

SDG 5 Gender Equality and Life Balance. SDG 13 Climate Action

Employ employees in accordance with laws and regulations to protect the legitimate rights and interests of employees; establish a fair and transparent corporate governance structure and internal control system; strengthen anti-corruption, governance systems and standardized governance corporate governance

Compliance management, clear performance appraisal, salary and promotion mechanisms; anti-bribery and business ethics management through standardized governance; establishing and operating ISO 27001 to practice caring for employees and business ethics

Human capital development and high-quality services promote stable business operations and high-quality industry / 27701 Information security management system to ensure data and privacy security Information security protects information security

SDG 8 Decent work and development. SDG 16 Peace and security.

Economic Growth Justice and Strong Institutions

1 Compared with the previous year, this report continues the company’s continued focus on the United Nations Sustainable Development Goals (SDGs), combined with the company’s business progress in 2025,

Actively participate in industry associations, academic exchanges and the construction of industry standards; in response to changes in governance practices and key issues, the SDGs index content has been updated and improved accordingly. This year’s update focuses on subject protection and information industry collaboration.

Collaborate with hospitals, universities and partners to promote the further refinement and enrichment of topics such as medical clinical safety, technological innovation, human capital development and climate action. Relevant actions have been systematically presented in the corresponding chapters of the report. social cooperation

Standardization and professionalization of bed research ecology.

SDG 17 Promote the achievement of goals

At the same time, based on the adjustment of the organizational structure and the deepening of management practices during the reporting period, the company adjusted the chapter names and action descriptions corresponding to some SDGs goals.

current partnership

In order to more accurately reflect the actual situation of the company's current sustainable development management. The company will continue to dynamically pay attention to SDGs based on business development stages and changes in the external environment.

relevant issues, and gradually improve the pertinence and reference value of disclosure in subsequent reports.

94 95

Disclosure Topic/Disclosure Item Disclosure Item Title Report Chapter

GRI Index

201-2 Financial impacts and other risks and opportunities brought about by climate change Addressing climate change

201-3 Compulsory defined benefit plans and other retirement plans Employee care and rights protection

GRI 202: Market Performance

Purisi (Shanghai) Pharmaceutical Technology Development Co., Ltd. will participate in the project from January 1, 2025 to December 31, 2025.

Instructions for use

Information cited in this GRI content index is reported in accordance with GRI standards 202-2 Proportion of executives hired from local communities Corporate governance performance

GRI 203: Indirect economic impacts

GRI 1 GRI 1 used: Basics 2021

203-1 Infrastructure investment and supporting services Social contribution

Disclosure Issue/Disclosure Item Disclosure Item Title Report Chapter

203-2 Significant indirect economic impact Social contribution

GRI 2: General Disclosures 2021

GRI 204: Procurement Practices

2-1 Organization details Company profile

Create a sustainable supply chain

204-1 Proportion of expenditure on procurement from local suppliers

2-2 Entities included in the organization’s sustainability report About this report Social responsibility performance 2-3 Reporting period, reporting frequency and contact person About this report GRI 205: Anti-corruption

2-4 Restatement of Information About this Report Governance Systems and Practices 205-1 Operations that have conducted corruption risk assessments

Company Profile Corporate Governance Performance

Stakeholder Management Governance Systems and Practices 2-6 Activities, value chains and other business relationships 205-2 Communication and training of anti-corruption policies and procedures

Responsible marketing and service Corporate governance performance to create a sustainable supply chain

Governance Systems and Practices 205-3 Confirmed corruption incidents and actions taken

Employee Care and Protection of Rights and Interests Corporate Governance Performance 2-7 Employees

Employee Responsibility Performance

GRI 206: Anti-competition

2-8 Workers other than employees Create a sustainable supply chain

Anti-competitive conduct, antitrust and antitrust practices

206-1 Governance system and practice

Governance Systems and Practices Legal Litigation

2-9 Governance structure and composition

corporate governance performance

GRI 302: Energy

2-10 Nomination and selection of the highest governance body Governance system and practice

302-1 Energy consumption within the organization Environmental performance 2-12 The supervisory role of the highest governance body in terms of management impact Governance system and practice

302-2 Energy consumption external to the organization Environmental performance

About this report

2-14 The role of the highest governance body in sustainability reporting 302-3 Energy intensity Environmental performance Sustainable development structure and management mechanism

GRI 303: Water Resources and Wastewater

sustainable development strategy

2-23 Policy Commitments 303-1 Interaction between the organization and water as a common resource Environmental management measures Employee care and rights protection

303-2 Management of impacts related to drainage Environmental management measures 2-24 Integration of policy commitments Governance systems and practices

303-3 Water Withdrawal Environmental Performance

Governance system and practice

2-25 Procedures for remediating negative impacts

Employee Care and Protection of Rights and Interests 303-4 Drainage Environmental Performance

Stakeholder Management GRI 305: Emissions

2-26 Mechanisms for seeking advice and raising concerns

Employee care and protection of rights and interests 305-1 Direct (scope 1) greenhouse gas emissions Addressing climate change 2-27 Compliance with laws and regulations For details, please see each chapter of the report Addressing climate change

305-2 Energy indirect (scope 2) greenhouse gas emissions

2-28 Membership of the Association Promoting Industry Cooperation Environmental Performance

2-29 Methods of Stakeholder Participation Stakeholder Management GRI 306: Waste

GRI 3: Material Topic 2021 Environmental Management Measures 306-1 Generation of waste and significant impacts related to waste

Environmental Performance 3-1 Process of Determining Material Issues Identification and Assessment of Material Issues

Environmental Management Measures 3-2 List of Material Issues Identification and Assessment of Important Issues 306-2 Management of Significant Impacts Related to Waste

Environmental Performance 3-3 Management of Material Issues Identification and Assessment of Material Issues

Environmental Management Measures GRI 201: Economic Performance 306-4 Waste diverted from disposal

Environmental Performance 201-1 Economic value directly generated and distributed Corporate governance performance

GRI 308: Supplier Environmental Assessment

96 97 Puris (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of Puris ESG Management Standardized Governance Quality Innovation Caring for Employees Green and Environmental Protection Appendix

Disclosure Topic/Disclosure Item Disclosure Item Title Report Chapter

SASB SV - PS indicator mapping table

308-1 Use environmental standards to select new suppliers to create a sustainable supply chain

308-2 Negative impacts of supply chains on the environment and actions taken to create a sustainable supply chain

SASB issue SASB indicator code SASB indicator name Report corresponding chapter GRI 401: Employment

401-1 New employee hiring rate and employee turnover rate Employee responsibility performance

Management of data security risk identification and response is provided to full-time employees (excluding temporary or part-time employees) SV-PS-230a.1 Information Security Protection 401-2 Employee Care and Rights Protection Management Method

benefits

GRI 403: Occupational Health and Safety

403-1 Occupational Health and Safety Management System Employee Care and Protection of Rights and Interests

Data Security Customer information collection, use and retention 403-2 Hazard identification, risk assessment and incident investigation Employee care and rights protection SV-PS-230a.2 Information security protection data security policy and practice

403-3 Occupational Health Services Employee Care and Protection of Rights and Interests

Occupational health and safety matters: worker participation, consultation and

403-4 Employee care and protection of rights and interests

communicate

Information Security Protection SV-PS-230a.3 Number and Impact of Data Security Incidents

403-5 Employee occupational health and safety training Employee care and rights protection

ESG Key Performance 403-6 Promote employee health, employee care and protection of rights and interests

Prevention and mitigation of occupational health issues directly related to business relationships

403-7 Employee care and protection of rights and interests

Safety impact Gender and diversity of employees and management Employee care and rights protection SV-PS-330a.1

403-8 Ratio of employees covered by the occupational health and safety management system Employee care and rights protection Structure Employee responsibility performance Employee care and rights protection

403-9 Work injury

Employee Responsibility Performance

Workforce Diversity &

403-10 Work-related health issues Employee care and protection of rights and interests

Engagement SV-PS-330a.2 Employee turnover rate Employee responsibility performance

GRI 404: Training and Education

Employee Diversity and Engagement

404-1 Average number of hours of training per employee per year Employee Responsibility Performance

404-2 Employee skills improvement plan and transition assistance plan Employee care and rights protection

Employee Care and Rights Protection 404-3 Percentage of employees who receive regular performance and career development assessments Employee Responsibility Performance

SV-PS-330a.3 Employee Engagement

Employee Responsibility Performance

GRI 405: Diversity and Equal Opportunity

corporate governance performance

405-1 Diversity of governance bodies and employees

Employee Responsibility Performance

Management to ensure professional ethics and professional integrity 405-2 Ratio of basic wages and remuneration for men and women Responsibility and performance of employees SV-PS-510a.1 Business ethics construction management approach

GRI 406: Anti-Discrimination

Professional Integrity

Employee care and rights protection

406-1 Discrimination Incidents and Corrective Actions Taken Ethics and Compliance

Employee Responsibility Performance

Business ethics construction GRI 414: Supplier social assessment SV-PS-510a.2 arising from professional ethics or compliance issues

Amount of lawsuits or fines ESG Key Performance 414-1 Use social criteria to screen new suppliers Create a sustainable supply chain

414-2 Negative impact of supply chain on society and actions taken to create a sustainable supply chain

GRI 416: Customer Health and Safety

SV-PS-000.A Number of employees by employment type Employee Responsibility Performance 416-1 Assess the health and safety impact of products and service categories Strengthen service quality

Violations involving health and safety impacts of products and services Activity Metrics

416-2 Strengthen service quality

pieces

activity indicators

GRI 418: Customer Privacy

SV-PS-000.B Employee working hours and billable working hours ratio Not applicable Evidence related to infringement of customer privacy and loss of customer information Information security protection

418-1

Substantial Complaints Corporate Governance Performance

98 99Purimis (Shanghai) Pharmaceutical Technology Development Co., Ltd. 2025 Environmental, Social and Corporate Governance Report Manager’s Speech Impression of PuriSi ESG Management Standardized Governance Quality Innovation Caring for Employees Green Environmental Protection Appendix

"Self-Regulatory Supervision Guidelines for Companies Listed on GEM of Shenzhen Stock Exchange No. 3" Reader Feedback

——Sustainable Development Report Preparation Index

Dear readers:

Dimension Issue Report Chapter Hello!

Tackling climate change Tackling climate change Thank you for reading this report. In order to continuously improve our reporting, we want to hear your comments and suggestions. Please help complete the relevant questions in the questionnaire and choose the following methods to provide feedback to us. Waste Disposal Environmental Compliance Management

Ecosystem and Biodiversity Protection Environmental Compliance Management

Our contact information:

environment

Environmental Compliance Management Environmental Compliance Management

Puruis (Shanghai) Pharmaceutical Technology Development Co., Ltd. Energy Utilization Efficient Utilization of Energy

Address:

Water Utilization Environmental Compliance Management

Phone:

Rural Revitalization Social Contribution

Postal code:

social contribution social contribution

Drive innovation to create innovative competitiveness. If convenient, you are welcome to provide information: Science and technology ethics Subject protection

Name:

Society Supply Chain Security Create a Sustainable Supply Chain

Work unit: Position: Treat small and medium-sized enterprises equally Treat small and medium-sized enterprises equally

Contact number: Email: Product and service safety and quality Strengthening service quality 1. What is your overall evaluation of this report? Data security and customer privacy protection Information security protection

Employees Employee care and rights protection

What do you think is the most satisfying aspect of this report? Stakeholder Management

Governance system and practice

due diligence

What other information do you think you would like to know that is not reflected in this report? Information security protection

Sustainability-related governance Sustainable supply chain

Stakeholder communication Stakeholder management

Do you have any suggestions for us to prepare sustainability reports in the future? Anti-Commercial Bribery and Anti-Corruption Governance System and Practice

Anti-unfair competition governance system and practice

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