Cubic Pharmaceuticals: Special report of the board of directors on self-examination of the independence of independent directors

Hefei Cube Pharmaceutical Co., Ltd.

Special report of the board of directors on the self-examination of the independence of independent directors

In accordance with the "Administrative Measures for Independent Directors of Listed Companies" and "Shenzhen Stock Exchange Self-Regulatory Guidelines for Listed Companies No. 1 - Standardized Operations of Main Board Listed Companies" and other regulations, the board of directors of Hefei Cube Pharmaceutical Co., Ltd. (hereinafter referred to as the "Company") evaluated the independence of the company's current independent directors Yang Morong, Li Jinhua and Shi Jing and issued the following special opinions:

After verifying the service experience of the independent directors and the relevant self-examination documents signed by them, the board of directors believes that the company's independent directors Yang Morong, Li Jinhua and Shi Jing do not have the circumstances that prohibit them from serving as independent directors as stipulated in Article 6 of the "Administrative Measures for Independent Directors of Listed Companies", and there is no relationship between them and the company and major shareholders that would hinder their independent and objective judgment. There is no relationship that affects the independence of independent directors, and it complies with laws and regulations such as the "Administrative Measures for Independent Directors of Listed Companies", "Shenzhen Stock Exchange Self-Regulatory Guidelines for Listed Companies No. 1 - Standardized Operation of Main Board Listed Companies" and the relevant requirements for the qualifications and independence of independent directors in the "Articles of Association".

Board of Directors of Hefei Cube Pharmaceutical Co., Ltd.

April 24, 2026