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/N-linked Glycan Removal Mutant Antibodies And Their Use Against Influenza Viruses
Abstract

Disclosed herein are vectors, synthetic antibodies, and methods of producing and using the same, comprising at least one polynucleotide sequence encoding an antibody or fragment thereof, wherein a variable heavy chain domain of the antibody or fragment thereof comprises SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, or SEQ ID NO: 7, and a variable light chain domain of the antibody or fragment thereof comprises SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or SEQ ID NO: 22; or wherein a variable heavy chain domain of the antibody or fragment thereof comprises SEQ ID NO: 23, and a variable light chain domain of the antibody or fragment thereof comprises SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, or SEQ ID NO: 8.

Full Text

What is claimed is:

Disclosed herein are vectors, synthetic antibodies, and methods of producing and using the same, comprising at least one polynucleotide sequence encoding an antibody or fragment thereof, wherein a variable heavy chain domain of the antibody or fragment thereof comprises SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, or SEQ ID NO: 7, and a variable light chain domain of the antibody or fragment thereof comprises SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, or SEQ ID NO: 22; or wherein a variable heavy chain domain of the antibody or fragment thereof comprises SEQ ID NO: 23, and a variable light chain domain of the antibody or fragment thereof comprises SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, or SEQ ID NO: 8.
Timeline
Filed
02/24/2026
Published
06/25/2026
Granted
Not Available
IPC Codes(1)
A61K 47/68:the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment