Differential driving and/or sensing can reduce noise in a touch screen. In some examples, the touch screen can include column and row electrodes routed vertically in the active area. In some examples, the touch electrodes and/or routing traces can be implemented using metal mesh in first and second metal layers. To improve optical performance, overlapping portions of metal mesh can be designed to provide an appearance of uniform width/area. In some examples, a dielectric layer can have an increased thickness and/or a reduced dielectric constant, and/or metal mesh in the first metal layer can be flooded with a transparent conductive material. In some examples, routing traces can be disposed beneath touch electrodes and/or metal mesh for touch electrodes can be flooded with a transparent conductive material without flooding metal mesh for routing traces. In some examples, touch electrodes can be interleaved within a touch node to improve differential cancelation.