Abstract
The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PA, NP, and NS gene segments having selected nucleotides and encoding proteins having amino acid sequences with selected amino acids. The invention also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus.
Full Text
What is claimed is:
The invention provides an influenza virus that demonstrates enhanced growth in Vero cells. The influenza virus includes PA, NP, and NS gene segments having selected nucleotides and encoding proteins having amino acid sequences with selected amino acids. The invention also provides a pharmaceutical formulation containing the influenza virus, as well as a method of eliciting an immune response in a mammal by administering the influenza virus to the mammal, and a method for generating the influenza virus.
Timeline
Filed
03/17/2026Published
07/02/2026Granted
Not AvailableIPC Codes(4)
C12N 7/00:Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof (medicinal preparations containing viruses A61K 35/76; preparing medicinal viral antigen or antibody compositions, e.g. virus vaccines, A61K 39/00)
A61K 39/00:Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N 33/53)
A61K 39/12:Viral antigens