The present invention extends to transaction handling in view of settlement factor compliance. Security action triggers subject pre-settlement transactions to one or more supplemental security actions prior to settlement approval. When it is determined that an identified factor impacts transaction settlement, a flag is set. The flag denotes that pre-settlement transactions associated with specified transaction data are subject to the one or more supplemental security actions prior to settlement. A transaction is reviewed, including interrupting the flow of the transaction and subjecting the transaction to the one or more supplemental security actions. The transaction is allowed to resume and progress towards settlement or is killed based on outcomes of the one or more supplemental security actions.