Abstract
Aspects of the present disclosure are directed to methods and compositions for facilitating β-cell regeneration by inhibition of the HIF1α-PFKFB3 pathway. Certain aspects describe methods for treatment and prevention of prediabetes and diabetes, including type 2 diabetes. Also disclosed are methods and compositions for enhancing β-cell regeneration.
Full Text
What is claimed is:
Aspects of the present disclosure are directed to methods and compositions for facilitating β-cell regeneration by inhibition of the HIF1α-PFKFB3 pathway. Certain aspects describe methods for treatment and prevention of prediabetes and diabetes, including type 2 diabetes. Also disclosed are methods and compositions for enhancing β-cell regeneration.
Timeline
Filed
03/16/2026Published
07/02/2026Granted
Not AvailableIPC Codes(7)
C07K 16/28:against receptors, cell surface antigens or cell surface determinants
A61K 31/444:containing a six-membered ring with nitrogen as a ring hetero atom, e.g. amrinone
A61K 31/4709:Non-condensed quinolines containing further heterocyclic rings