Disclosed herein include systems, methods, compositions, and kits for labeling nucleic acid targets. Some embodiments provide oligonucleotide barcodes comprising a cleavage region. The cleavage region can comprise one or more cleavage sites. In some embodiments, cleaving agents are capable of effectuating cleavage of a phosphodiester backbone of the cleavage region. The oligonucleotide barcode can be associated with a solid support. Methods of separating barcoded nucleic acid molecules from the solid support are also provided in some embodiments.