/Intratumoral Alpha-emitter Radiation And Activation Of Cytoplasmatic Sensors For Intracellular Pathogen
Abstract
A method of treating a patient with a tumor, comprising administering, to the patient, a substance which activates cytoplasmatic sensors for intracellular pathogen in the tumor, in one or more doses; and treating the tumor with intra-tumoral alpha-emitter radiotherapy within two weeks of administering the substance which activates cytoplasmatic sensors for intracellular pathogen in the tumor, and at least 12 hours after administering the substance. The substance is selected from the group of a DNA methyltransferase (DNMT) inhibitor, and a histone deacetylase (HDAC) inhibitor.
Full Text
What is claimed is:
A method of treating a patient with a tumor, comprising administering, to the patient, a substance which activates cytoplasmatic sensors for intracellular pathogen in the tumor, in one or more doses; and treating the tumor with intra-tumoral alpha-emitter radiotherapy within two weeks of administering the substance which activates cytoplasmatic sensors for intracellular pathogen in the tumor, and at least 12 hours after administering the substance. The substance is selected from the group of a DNA methyltransferase (DNMT) inhibitor, and a histone deacetylase (HDAC) inhibitor.
Timeline
Filed
03/05/2026Published
07/09/2026Granted
Not AvailableIPC Codes(14)
A61K 31/7068:having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 31/167:having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
A61K 31/4406:only substituted in position 3, e.g. zimeldine (nicotinic acid A61K 31/455)