Abstract
DNA ligase compositions, guide polynucleotides, donor nucleic acids, systems, methods, and uses thereof are provided. Methods of modifying a target nucleic acid and genetically modifying a cell are described. The methods can be used for biotechnology applications, therapeutic treatments and for generating cell therapies for the treatment of various diseases and conditions. Also included are scaffolds and kits comprising the compositions and systems described herein.
Full Text
What is claimed is:
DNA ligase compositions, guide polynucleotides, donor nucleic acids, systems, methods, and uses thereof are provided. Methods of modifying a target nucleic acid and genetically modifying a cell are described. The methods can be used for biotechnology applications, therapeutic treatments and for generating cell therapies for the treatment of various diseases and conditions. Also included are scaffolds and kits comprising the compositions and systems described herein.
Timeline
Filed
03/19/2026Published
07/09/2026Granted
Not AvailableIPC Codes(5)
C12N 9/22:Ribonucleases
C12N 9/00:Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof (preparations containing enzymes for cleaning teeth A61K 8/66, A61Q 11/00; medicinal preparations containing enzymes or proenzymes A61K 38/43; enzyme containing detergent compositions C11D); Processes for preparing, activating, inhibiting, separating, or purifying enzymes
C12N 15/113:Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides