A dialysis system and dialysis machine or cycler are provided that decrease a disposable set's cost and complexity. The dialysis machine or cycler includes a weigh scale on which multiple fluid supply containers containing dialysis fluid, and a drain trolley, are positioned. The fluid supply containers may be elevated relative to the drain trolley. The drain trolley is sized to contain all of the effluent drained from a patient during a dialysis treatment. The fluid supply containers are in fluid communication with one another and arranged one of top of the other. A control unit may control fill, dwell and drain cycles by controlling the operation of a pump and a valve. Dialysis fluid from the bottom-most fluid supply container may be pumped into a patient. The valve may be opened to allow effluent to drain from the patient to the drain trolley by way of gravity.