A smart bra with optical sensors for detecting, imaging, and/or evaluating abnormal breast tissue includes a cup with a proximal outer ring, expandable chambers inside the proximal outer ring, and light emitters and light receivers between the expandable chambers and a person's breast. Changes in light emitted from the light emitters and received by the light receivers which are caused by transmission of the light through breast tissue can be analyzed to detect, image, and evaluate abnormal breast tissue.