Provided is a transgenic recombinant immune cell specifically targeting a tumor. The recombinant immune cell includes a chimeric polypeptide and a chimeric antigen receptor. The chimeric polypeptide includes a first extracellular region having an activity of binding to HLA-G protein, a first transmembrane region, and a first intracellular region. The N-terminus of the first transmembrane region is linked to the C-terminus of the first extracellular region. The N-terminus of the first intracellular region is linked to the C-terminus of the first transmembrane region. The first transmembrane region includes a transmembrane region of Xenopus tropicalis Notch receptor protein. The chimeric antigen receptor does not have an HLA-G protein-binding activity.