The present disclosure provides a method of facilitating AI-driven refinement of mental health diagnostics and personalized treatment. The method may include transmitting a prompt data to a user device. Further, the method may include receiving a mental health data from the user device based on the prompt data. Further, the mental health data may be associated with a user. Further, the method may include identifying a demography data based on the mental health data. Further, the method may include determining a diagnostic schema data to provide diagnostic insights based on the demography data. Further, the method may include generating a pre-diagnosis and/or diagnosis report data to provide personalized insights based on the diagnostic schema data and the mental health data. Further, the method may include transmitting the pre-diagnosis and/or diagnosis report data to the user device.