A surgical instrument includes an end effector assembly having first and second jaw members configured to grasp tissue therebetween. The first jaw member including first and second electrically conductive tissue contacting plate portions configured to conduct Radio Frequency (RF) energy through tissue and the second jaw member including first and second ultrasonic tissue contacting plate portions configured to produce ultrasonic vibration energy and transmit the ultrasonic vibration energy to tissue. A surgical system includes an end effector assembly configured to grasp tissue and a surgical generator configured to output RF treatment energy, output an ultrasonic drive signal, sense RF energy feedback, sense ultrasonic energy feedback, and control the outputs based upon the feedback.