Provided is molecular nanoparticle microcarriers and the related methods. The preparation method of the molecular nanoparticle microcarriers includes: S1, stimulating mesenchymal stem cells (MSCs) to produce vesicles and collecting the vesicles by centrifugation; wherein the MSCs overexpress CXCR4 and PSGL-1, and a preparation process of the MSCs includes: (a) constructing a recombinant vector of CXCR4 and PSGL-1 using molecular biology techniques; (b) packaging lentivirus in 293T cells using the recombinant vector of CXCR4 and PSGL-1; and (c) collecting the lentivirus, infecting MSCs with concentrated lentivirus, and screening positive cells expressing both CXCR4 and PSGL-1 using antibiotic tags and a flow cytometry to obtain a stable MSCs line that overexpresses CXCR4 and PSGL-1; S2, preparing small interfering ribonucleic acids-loaded polypeptide dendrimer nanoparticles (PDNPs-siRNAs); and S3, mixing and extruding the vesicles with the PDNPs-siRNAs, to obtain the molecular nanoparticle microcarriers (M@PDNPs-siRNAs).