The present invention relates to a modified BoNT/A for use in treating facial lines, wherein the modified BoNT/A is administered by intramuscular injection at a plurality of sites of the face of the subject, wherein the plurality of sites are selected from: up to two sites of a corrugator muscle and one site of a procerus muscle for treating glabellar lines, up to five sites of a frontalis muscle for treating forehead lines; and up to three sites at the external part of an orbicularis oculi muscle for treating lateral canthal lines, and wherein the modified BoNT/A comprises a substitution, insertion or deletion at one or more amino acid residue(s). Also provided are corresponding methods of treatment and uses, unit doses, total doses as well as unit dosage forms, and kits.