A fluid detection system includes a fluid detection sensor disposed at a fluid sensing portion of the system, and a reference sensor disposed at a reference sensing portion of the system. The detection sensor and the reference sensor are subject to at least one common ambient environmental condition, such that the detection sensor exhibits an electrical characteristic that is different from an electrical characteristic of the reference sensor when fluid contacts the detection sensor. The fluid sensing portion may be within an internal fluid passage of a conduit that is removably couplable to a fluid device. Alternatively or additionally, the fluid sensing portion may be disposed in a fluid flow path, such as a leak path, in a permanent structure of a fluid device. The reference sensor may be disposed in a location away from and/or intentionally divided from the fluid flow path. The system may include a warning system.