A quick balloon clip with a compression and locking structure is provided, and belongs to the technical field of daily supplies. The quick balloon clip with the compression and locking structure includes an integrally formed clip body. A guide slot is formed in an edge of the clip body. A compression opening is formed in a position, corresponding to a bottom of the guide slot, on the clip body. The quick balloon clip with the compression and locking structure is easy and convenient to operate and achieves knotless sealing on a balloon. The quick balloon clip has a simple structure, can be repeatedly used, and is highly environmentally-friendly.