/Methods Of Treating And Preventing Clostridioides Difficile Using A Recombinant Fusion Protein Vaccine Containing Flic And Flid
Abstract
A novel vaccine and methods of preventing and treating C. difficile infection in a patient is described. The vaccine is comprised of a fusion protein (denoted FliCD) comprised of the FliC and FliD from C. difficile and joined by a linker sequence. Administration of the vaccine, as well as anti-FliCD serum, has been shown to prevent C. difficile infection as well as treat existing infections.
Full Text
What is claimed is:
A novel vaccine and methods of preventing and treating C. difficile infection in a patient is described. The vaccine is comprised of a fusion protein (denoted FliCD) comprised of the FliC and FliD from C. difficile and joined by a linker sequence. Administration of the vaccine, as well as anti-FliCD serum, has been shown to prevent C. difficile infection as well as treat existing infections.
Timeline
Filed
04/07/2026Published
07/30/2026Granted
Not AvailableIPC Codes(3)
A61K 39/08:Clostridium, e.g. Clostridium tetani
A61K 35/16:Blood plasma; Blood serum (umbilical cord blood A61K 35/51)
C07K 14/33:from Clostridium (G)