Provided herein is a system for sequential delivery of therapeutic compositions, including a first fluid source and a second fluid source, one or more first sensors associated with each of the first fluid source and the second fluid source, an actuator-actuated valve, and a processor in communication with the one or more sensors, wherein the processor is programmed or configured to control, based on data received from the one or more sensors, the actuator-actuated valve to stop and/or cause delivery of therapeutic compositions from the fluid sources.