Provided are an information processing system, an image processing device, an optical device, an information processing method, and a program configured to acquire a good image from a plurality of polarization images obtained by imaging an object. An information processing system includes one or more processors, in which the one or more processors are configured to acquire a plurality of polarization images acquired by imaging an object in a plurality of imaging directions in a state in which polarization directions are different from each other, and acquire a first image from the two or more polarization images.