An electronic device for user-customized healthcare and an operation method are provided. The method includes receiving an access request from an external electronic device, receiving a user input for the access request, transmitting personal information including personal device information for at least one device to the external electronic device based on the user input, receiving device configuration information generated based on the personal information and a digital prescription from the external electronic device, generating healthcare guide information related to the at least one device based on the device configuration information, and displaying a user interface for guiding a health activity based on the healthcare guide information, and transmitting a device control command to the at least one device to support the health activity.