Abstract
Systems and methods for promoting protein endosomal escape comprise selecting or engineering the protein according to design rules, including relatively high intrinsic disorder and/or thermal stability (Tm) to unfold at physiological temperatures.
Full Text
What is claimed is:
Systems and methods for promoting protein endosomal escape comprise selecting or engineering the protein according to design rules, including relatively high intrinsic disorder and/or thermal stability (Tm) to unfold at physiological temperatures.
Timeline
Filed
04/11/2026Published
08/13/2026Granted
Not AvailableIPC Codes(1)
A61K 47/64:Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent (peptidic linkers A61K 47/65)