Abstract
Described herein are anti-NaPi2b antibody-drug conjugates (ADCs) comprising an antibody construct that binds human sodium-dependent phosphate transporter 2B (NaPi2b) conjugated to a camptothecin analogue of Formula (I). The antibody construct of the ADC comprises amino acid modifications in the Fc that knock-out binding to Fcγ receptors. ADCs are useful as therapeutics, in particular in the treatment of cancer.
Full Text
What is claimed is:
Described herein are anti-NaPi2b antibody-drug conjugates (ADCs) comprising an antibody construct that binds human sodium-dependent phosphate transporter 2B (NaPi2b) conjugated to a camptothecin analogue of Formula (I). The antibody construct of the ADC comprises amino acid modifications in the Fc that knock-out binding to Fcγ receptors. ADCs are useful as therapeutics, in particular in the treatment of cancer.
Timeline
Filed
04/10/2026Published
08/13/2026Granted
Not AvailableIPC Codes(3)
A61K 47/68:the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61P 35/00:Antineoplastic agents
C07K 16/28:against receptors, cell surface antigens or cell surface determinants