The present disclosure may provide a method and a system for anomaly detection of a carrier plate. The method may be implemented by the system for anomaly detection of a carrier plate including at least a processor and a storage device. The method may include: obtaining point cloud data of the carrier plate and a subject placed on the carrier plate; obtaining at least one data block by segmenting the point cloud data; and performing an anomaly detection of the carrier plate based on the at least one data block.