Abstract
Described herein are 4-N-derivatized sialic acid compounds and efficient chemoenzymatic methods for synthesizing sialosides containing the 4-N-derivatized sialic acid. Methods of using the 4-N-acyl sialic acids and sialosides are also described herein. Described also herein are 8-N-derivatized sialic acid compounds and methods for synthesizing and using the same.
Full Text
What is claimed is:
Described herein are 4-N-derivatized sialic acid compounds and efficient chemoenzymatic methods for synthesizing sialosides containing the 4-N-derivatized sialic acid. Methods of using the 4-N-acyl sialic acids and sialosides are also described herein. Described also herein are 8-N-derivatized sialic acid compounds and methods for synthesizing and using the same.
Timeline
Filed
04/23/2026Published
08/20/2026Granted
Not AvailableIPC Codes(7)
C07H 15/26:Acyclic or carbocyclic radicals, substituted by hetero rings
A61K 31/7012:Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid (gluconic acid A61K 31/191; ascorbic acid A61K 31/375)
A61K 31/7048:having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin