Techniques for configuring one or more applications based on a detected wakefulness state of a user are disclosed. A system trains and applies a machine learning model to wakefulness data to compute a wakefulness state of a user. The system obtains the wakefulness data from wearable devices worn by the user and environmental devices in a user's environment. The system configures applications and/or devices based on the computed wakefulness state of the user. The system configures the ability of devices or applications to generate visual, audible, or tactile notifications in response to determining that a user is awake or asleep.