Provided herein is a DNA analysis method for DNA in an amplified, adapted library, comprising capturing a plurality of target regions comprising sequence-variable target regions and recombined CDR3 sequences from the amplified, adapted library or one or more subsamples thereof, wherein the recombined CDR3 sequences are captured using a plurality of capture probes comprising CDR3 capture probes, each CDR3 capture probe comprising a first region complementary to a V region, a second region comprising a spacer, and a third region complementary to a J region, thereby providing captured recombined CDR3 sequences and captured sequence-variable target regions; and sequencing the captured sequence-variable target regions and the recombined CDR3 sequences.