Proposed is a real time virtual sensor monitoring system for multi use facilities, and an operating method of the real time virtual sensor monitoring system. The system may include an input processor creating a plurality of air conditioner measurement data and a plurality of indoor environmental measurement data in a multi use facility. The system may also include a calculation processor including a preprocessing processor receiving and preprocessing the plurality of air conditioner measurement data and the plurality of indoor environmental measurement data. The system may further include a simulation processor receiving preprocessed data through the preprocessing processor and performing simulation. The system may further include a parameter creation processor transmitting information dividing the multi use facility into o (o is a natural number) zone to the calculation processor, and an output processor receiving the result of the simulation through the calculation processor and outputting virtual sensor distribution.