Systems and methods are described herein for processing electronic medical images to optimize a review order of pathology cases. For example, a plurality of variables and one or more constraints may be received along with a plurality of pathology cases. Each case of the plurality of pathology cases may include one or more medical images of at least one pathology specimen associated with a patient. The medical images from each case, the plurality of variables, and the one or more constraints may be provided as input to a trained system. A sequential order for user review of the plurality of cases to optimize one or more of the plurality of variables based on the one or more constraints may be received as output of the trained system. Each case of the plurality of cases may be automatically provided to a user for review according to the sequential order.