/Delivery Of A Cooling Agent To The Pharyngeal-esophageal Surface
Abstract

Disclosed are methods and compositions for treating symptoms of esophageal disorders by localized delivery of a cooling agent to pharyngeal and upper esophageal surfaces. A solid medicament comprising a cooling agent incorporated into a gelatin-based matrix is orally administered. The medicament has a non-spherical geometry for temporary retention within anatomical recesses of the pharynx prior to passage into the esophagus. The medicament has a mass and geometry selected for prolonged pharyngeal residence while permitting spontaneous swallowing.

Full Text

What is claimed is:

Disclosed are methods and compositions for treating symptoms of esophageal disorders by localized delivery of a cooling agent to pharyngeal and upper esophageal surfaces. A solid medicament comprising a cooling agent incorporated into a gelatin-based matrix is orally administered. The medicament has a non-spherical geometry for temporary retention within anatomical recesses of the pharynx prior to passage into the esophagus. The medicament has a mass and geometry selected for prolonged pharyngeal residence while permitting spontaneous swallowing.
Timeline
Filed
05/03/2026
Published
09/10/2026
Granted
Not Available
IPC Codes(3)
A61K 31/66:Phosphorus compounds
A61K 31/221:with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
A61P 1/00:Drugs for disorders of the alimentary tract or the digestive system