Abstract
Disclosed herein are compositions for engineering a human cell comprising a cell modulating agent or a vector encoding the cell modulating agent. Described herein are compositions comprising an engineered cell, wherein the engineered cell is an engineered human cell and comprises a modification such that the engineered cell is more resistant to an alkylating drug or a nucleoside analog relative to a non-engineered human cell. Various methods of treating a disease are provided, including a method of treating cancer in a subject by administering the cell modulating agents and/or engineered cells as a therapeutic.
Full Text
What is claimed is:
Disclosed herein are compositions for engineering a human cell comprising a cell modulating agent or a vector encoding the cell modulating agent. Described herein are compositions comprising an engineered cell, wherein the engineered cell is an engineered human cell and comprises a modification such that the engineered cell is more resistant to an alkylating drug or a nucleoside analog relative to a non-engineered human cell. Various methods of treating a disease are provided, including a method of treating cancer in a subject by administering the cell modulating agents and/or engineered cells as a therapeutic.
Timeline
Filed
05/22/2026Published
09/10/2026Granted
Not AvailableIPC Codes(4)
C12N 9/12:transferring phosphorus containing groups, e.g. kinases (2.7)
A61P 35/00:Antineoplastic agents
C12N 9/04:acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)