A non-transitory computer-readable recording medium having stored therein an information processing program causes a computer to execute a process including: determining a weight of an input feature in a regression model, the regression model predicting an amino-acid sequence of a virus after mutation using an amino-acid sequence of the virus as the input feature, the determining being based on a first feature related to a three-dimensional (3D) structure of a protein of the virus and a second feature related to a contribution to prediction of a machine learning model, the contribution being obtained based on the first feature.