The present invention discloses a lighting device with a flexible circuit board connection structure, which includes a cylindrical light cover, a light source board and a flexible circuit board. The light source board is disposed in the cylindrical light cover and includes a plurality of electrodes. The flexible circuit board includes a soldering structure corresponding to the light source board, and the soldering structure includes a plurality of soldering pads. The electrodes of the light source board are respectively soldered to the soldering pads of the soldering structure.