A vehicle control system an onboard controller device to interface with a propulsion system and a brake system. A remote controller device wirelessly communicates with the onboard controller device and receives input from an operator, generates control signals based on the input, wirelessly communicates the control signals to the onboard controller device while the vehicle system moves along one or more main line routes. A method includes receiving input from an operator at a remote controller device, generating control signals at the remote controller device based on the input from the operator, wirelessly communicating the control signals to an onboard controller device, controlling one or more of a propulsion system or a brake system of the vehicle system to change movement of the vehicle system while the vehicle system moves along one or more main line routes.