Abstract
An anti-TSLP nanobody and a use thereof are provided. A coding sequence encoding the anti-TSLP nanobody, corresponding expression vector and host cell capable of expressing the nanobody, and a method for producing the anti-TSLP nanobody are also provided. The anti-TSLP nanobody has a good TSLP/TSLPR blocking activity and is expressed using Pichia pastoris. Its fermenter expression yield can reach 17-23 g/L.
Full Text
What is claimed is:
An anti-TSLP nanobody and a use thereof are provided. A coding sequence encoding the anti-TSLP nanobody, corresponding expression vector and host cell capable of expressing the nanobody, and a method for producing the anti-TSLP nanobody are also provided. The anti-TSLP nanobody has a good TSLP/TSLPR blocking activity and is expressed using Pichia pastoris. Its fermenter expression yield can reach 17-23 g/L.
Timeline
Filed
05/22/2026Published
09/17/2026Granted
Not AvailableIPC Codes(6)
C07K 16/24:against cytokines, lymphokines or interferons
A61K 47/68:the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
A61K 47/69:the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit