Abstract
Described herein are DNA nanostructures (DN) functionalized with proteins and methods for cellular uptake. Cellular uptake of such DNs is linearly dependent on the cell size. The protein corona determines the endolysosomal vesicle escape efficiency of DNs coated with an endosome escape peptide.
Full Text
What is claimed is:
Described herein are DNA nanostructures (DN) functionalized with proteins and methods for cellular uptake. Cellular uptake of such DNs is linearly dependent on the cell size. The protein corona determines the endolysosomal vesicle escape efficiency of DNs coated with an endosome escape peptide.
Timeline
Filed
05/28/2026Published
09/17/2026Granted
Not AvailableIPC Codes(3)
A61K 47/69:the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 47/62:the modifying agent being a protein, peptide or polyamino acid
B82Y 5/00:Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery