Aspects include a toothbrush and related methods of brushing teeth. In some cases, a toothbrush includes: a head including a core and a set of brushing portions extending from the core, the set of brushing portions including an upper brushing portion and a lower brushing portion, wherein the upper brushing portion and the lower brushing portion are oriented and spaced apart relative to one another to enable a provider to brush upper teeth and lower teeth of a subject without removing the head from the mouth of the subject, and a handle coupled with the head, the handle including at least one longitudinal portion positioned relative to the head such that a hand of the provider is oriented at a distinct angle from the head while brushing the teeth of the subject and holding the at least one longitudinal portion.