An orthopedic intramedullary (“IM”) nail for internal fixation of a patient’s bone is disclosed. In some examples, the IM nail is arranged and configured as a tibial IM nail arranged and configured for implantation into a patient’s tibia. In some examples, the tibial IM nail is arranged and configured to be side-specific so that the anatomic specific tibial IM nails can be used to, for example, target specific bony anatomy such as, for example, the patient’s posterior malleolus. In addition, the tibial IM nail may include a variable angle screw opening in the distal end portion thereof to target specific bony anatomy such as, for example, the patient’s posterior malleolus, while avoiding anatomic structures such as nerves, vessels, tendons, etc. In addition, and/or alternatively, the tibial IM nail may include a variable angle screw opening in the proximal end portion thereof to enhance screw positioning.