A system, method, and computer-program product includes transmitting, to an autonomous artificial intelligence (AI) agent, message data of an electronic message that evaded a set of threat detection instructions provided by a threat detection and response service, detecting, based on the autonomous AI agent assessing the message data of the electronic message, a message signature associated with the electronic message, determining, based on the autonomous AI agent assessing the message signature against the set of threat detection instructions, a detection gap resolution operation to resolve a detection gap identified within the threat detection and response service, generating, using a language model associated with the autonomous AI agent and in accordance with the detection gap resolution operation, a candidate threat detection instruction, and iteratively modifying, by the autonomous AI agent, the candidate threat detection instruction over a plurality of iterations to generate a production-ready threat detection instruction.