A universal flow limiter assembly includes a body configured to receive a portion of an intravenous (IV) tube, the body comprising two opposing side beams, a hinge portion disposed at a first end of the body, wherein the hinge portion is a squared U-shaped joining of the opposing side beams, a control portion disposed at a second end of the body, a groove defined between the side beams and disposed between the hinge portion and the control portion, and a control knob, wherein the universal flow limiter assembly is configured to regulate a flow rate of fluid flowing through the IV tube. An IV set with a universal flow limiter assembly and methods of operating a universal flow limiter assembly are also provided.