A vehicle control system and method may include one or more processors that may receive a data set associated with plural waypoint locations along one or more routes. The data set may indicate plural waypoint locations, target arrival time windows for a vehicle system to reach the plural waypoint locations, and priority ranks of the plural waypoint locations. The processors may create and/or adjust a pacing trip plan based on the data set. The pacing trip plan may designate one or more operational settings of the vehicle system as a function of time, distance, and/or location. The pacing trip plan may be created and/or adjusted to direct the vehicle system to reach one or more of the plural waypoint locations within the corresponding target arrival time windows.