Disclosed herein are devices, systems, and methods relating to A hand exerciser assembly can include a base, a hand exerciser, a hand attachment mechanism, and a hand exerciser engine. The base can be configured to support the hand exerciser assembly. The hand exerciser can be coupled to the base and configured to removably receive a hand of a user and to exercise hand, wrist, or both muscle groups and to isolate a digit of the hand to be exercised. The hand attachment mechanism coupled to the hand exerciser and configured to secure the hand to the hand exerciser. The hand exerciser engine operatively coupled to the hand exerciser and configured to cause the hand exerciser to exercise the hand.